Direct in vitro and in vivo monitoring of destruxins metabolism in insects using internal surface reversed-phase high-performance liquid chromatography : I. Behaviour of E destruxin in locusts
High-performance liquid chromatography with internal surface reversed-phase packing provides an analytical tool for studying the in vitro and in vivo metabolism of A and E destruxins in the haemolymph and various organs of male adults of Locusta migratoria. A slight amount of injected E destruxin is...
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| Veröffentlicht in: | Journal of chromatography. Biomedical applications 1991-05, Vol.566 (2), p.511-524 |
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| container_title | Journal of chromatography. Biomedical applications |
| container_volume | 566 |
| creator | Cherton, J.-C. Lange, C. Mulheim, C. Païs, M. Cassier, P. Vey, A. |
| description | High-performance liquid chromatography with internal surface reversed-phase packing provides an analytical tool for studying the
in vitro and
in vivo metabolism of A and E destruxins in the haemolymph and various organs of male adults of
Locusta migratoria. A slight amount of injected E destruxin is shown to be hydrated into E-diol destruxin in the haemolymph. The rest of the toxin is recovered unchanged in the fat-body, pericardial tissues and Malpighian tubules, and some further E-diol destruxin formation occurs in these organs. Because E-diol destruxin is only weakly toxic, this appears to be a detoxication process. |
| doi_str_mv | 10.1016/0378-4347(91)80268-H |
| format | Article |
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in vitro and
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in vitro and
in vivo metabolism of A and E destruxins in the haemolymph and various organs of male adults of
Locusta migratoria. A slight amount of injected E destruxin is shown to be hydrated into E-diol destruxin in the haemolymph. The rest of the toxin is recovered unchanged in the fat-body, pericardial tissues and Malpighian tubules, and some further E-diol destruxin formation occurs in these organs. Because E-diol destruxin is only weakly toxic, this appears to be a detoxication process.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/0378-4347(91)80268-H</doi><tpages>14</tpages></addata></record> |
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| ispartof | Journal of chromatography. Biomedical applications, 1991-05, Vol.566 (2), p.511-524 |
| issn | 0378-4347 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_4422704 |
| source | Alma/SFX Local Collection |
| subjects | Biochemistry. Physiology. Immunology Biological and medical sciences Fundamental and applied biological sciences. Psychology Insecta Invertebrates Physiology. Development |
| title | Direct in vitro and in vivo monitoring of destruxins metabolism in insects using internal surface reversed-phase high-performance liquid chromatography : I. Behaviour of E destruxin in locusts |
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