Central Nervous System Effects of Human Immunodeficiency Virus Type 1
Following its early entry into the central nervous system (CNS), HIV-1 alters cerebral cell architecture and may subsequently affect higher cognitive functions, leading eventually in some patients to HIV-1 encephalopathy. The CNS may also be the target of opportunistic infections and malignancy seco...
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| Veröffentlicht in: | Annual review of medicine 1990-01, Vol.41 (1), p.159-168 |
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| container_end_page | 168 |
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| container_title | Annual review of medicine |
| container_volume | 41 |
| creator | Bridge, T P Ingraham, L J |
| description | Following its early entry into the central nervous system (CNS), HIV-1 alters cerebral cell architecture and may subsequently affect higher cognitive functions, leading eventually in some patients to HIV-1 encephalopathy. The CNS may also be the target of opportunistic infections and malignancy secondary to HIV-1 immunosuppression. Studies at the cellular, anatomical, and behavioral levels present evidence for significant involvement of the CNS in HIV-1 disease, while initial reports of treatment strategies hold promise for providing some amelioration in affected individuals. |
| doi_str_mv | 10.1146/annurev.me.41.020190.001111 |
| format | Article |
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Studies at the cellular, anatomical, and behavioral levels present evidence for significant involvement of the CNS in HIV-1 disease, while initial reports of treatment strategies hold promise for providing some amelioration in affected individuals.</description><subject>AIDS Dementia Complex - drug therapy</subject><subject>AIDS Dementia Complex - epidemiology</subject><subject>AIDS Dementia Complex - etiology</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>HIV-1</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Incidence</subject><subject>Medical sciences</subject><subject>United States - epidemiology</subject><issn>0066-4219</issn><issn>1545-326X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1LxDAQhoMouq7-BKGgeGvNdxu8KMvqCqIHP_AW0nQKlaZdk3Zl_71dWryKc5nDPDPv8CB0TnBCCJdXpml6D5vEQcJJgikmCicYk6H20IwILmJG5cc-mmEsZcwpUUfoOIRPjLFiLDtEh5RkPKV4hpYLaDpv6ugJ_KbtQ_SyDR24aFmWYLsQtWW06p1pogfn-qYtoKxsBY3dRu-VH_DX7RoicoIOSlMHOJ36HL3dLV8Xq_jx-f5hcfsYG85YF-dCpFRysIQKkxeykJnMMmqpzIU1TFAlSm5NoQRRQirLTG4LkQIrcqFApWyOLse7a99-9RA67apgoa5NA8PzOlUpTwUlf4JEqCwTSg7g9Qha34bgodRrXznjt5pgvbOtJ9vageZEj7b1aHvYPpti-txB8bs76R3mF9PcBGvq0pvGVuEX44zLlIoBuxmxXZaph7QKvsO_PvkBqgmfuQ</recordid><startdate>19900101</startdate><enddate>19900101</enddate><creator>Bridge, T P</creator><creator>Ingraham, L J</creator><general>Annual Reviews</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900101</creationdate><title>Central Nervous System Effects of Human Immunodeficiency Virus Type 1</title><author>Bridge, T P ; Ingraham, L J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a433t-b557264ec125abd6d686882c26b5ca35295f4cad9519569c3abcd57e3db59e973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>AIDS Dementia Complex - drug therapy</topic><topic>AIDS Dementia Complex - epidemiology</topic><topic>AIDS Dementia Complex - etiology</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>HIV-1</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Incidence</topic><topic>Medical sciences</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bridge, T P</creatorcontrib><creatorcontrib>Ingraham, L J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bridge, T P</au><au>Ingraham, L J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central Nervous System Effects of Human Immunodeficiency Virus Type 1</atitle><jtitle>Annual review of medicine</jtitle><addtitle>Annu Rev Med</addtitle><date>1990-01-01</date><risdate>1990</risdate><volume>41</volume><issue>1</issue><spage>159</spage><epage>168</epage><pages>159-168</pages><issn>0066-4219</issn><eissn>1545-326X</eissn><coden>ARMCAH</coden><abstract>Following its early entry into the central nervous system (CNS), HIV-1 alters cerebral cell architecture and may subsequently affect higher cognitive functions, leading eventually in some patients to HIV-1 encephalopathy. 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| fulltext | fulltext |
| identifier | ISSN: 0066-4219 |
| ispartof | Annual review of medicine, 1990-01, Vol.41 (1), p.159-168 |
| issn | 0066-4219 1545-326X |
| language | eng |
| recordid | cdi_pascalfrancis_primary_4346725 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | AIDS Dementia Complex - drug therapy AIDS Dementia Complex - epidemiology AIDS Dementia Complex - etiology AIDS/HIV Biological and medical sciences HIV-1 Humans Immunopathology Incidence Medical sciences United States - epidemiology |
| title | Central Nervous System Effects of Human Immunodeficiency Virus Type 1 |
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