Regulation of Apoptosis in Transgenic Mice by Simian Virus 40 T Antigen- Mediated Inactivation of p53

Several proteins encoded by DNA tumor viruses are thought to disrupt cellular growth control by interacting with key cellular proteins, such as p53 and pRB, that normally function to regulate cell growth. However, the biological consequences of intracellular complexing between the viral oncoproteins...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-04, Vol.91 (9), p.3979-3983
Hauptverfasser:	McCarthy, Susan A., Symonds, Holly S., Van Dyke, Terry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Polyomavirus Transforming - genetics Antigens, Polyomavirus Transforming - metabolism Apoptosis B lymphocytes Biological and medical sciences Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Clonal Deletion Deoxyribonucleic acid DNA Fundamental and applied biological sciences. Psychology Gene Rearrangement, beta-Chain T-Cell Antigen Receptor Genes, p53 Lymphoma, T-Cell - genetics Mice Mice, Transgenic Molecular and cellular biology Receptors, Antigen, T-Cell - genetics Rodents T cell antigen receptors T lymphocytes T-Lymphocytes - chemistry Thymocytes Thymus Gland - cytology Transgenic animals Tumor Suppressor Protein p53 - physiology Tumors Viral tumor antigens Viruses
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