Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia
Samples of iris ciliary body, choroid and retina from normal eyes and from 2 cases of sympathetic ophthalmitis (one acute and one late stage fibrosis) were examined for the expression of the VLA integrins pl and a 1-6, and the integrin β3, in addition to ICAM-1, VCAM-1, ELAM-1 and CD44 using an APAA...
Gespeichert in:
| Veröffentlicht in: | Current eye research 1993, Vol.12 (10), p.923-934 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 934 |
|---|---|
| container_issue | 10 |
| container_start_page | 923 |
| container_title | Current eye research |
| container_volume | 12 |
| creator | Kuppner, M. C. Liversidge, J. McKillop-Smith, S. Lumsden, L. Forrester, J. V. |
| description | Samples of iris ciliary body, choroid and retina from normal eyes and from 2 cases of sympathetic ophthalmitis (one acute and one late stage fibrosis) were examined for the expression of the VLA integrins pl and a 1-6, and the integrin β3, in addition to ICAM-1, VCAM-1, ELAM-1 and CD44 using an APAAP staining technique.
The expression of VLA-4, VLA-5, VCAM-1, ICAM-1, and CD44 was significantly increased and ELAM-1 was slightly increased in acute sympathetic ophthalmitis in comparison to fibrotic and normal eyes.
VLA-6 was moderately increased in acute and fibrotic cases and VLA-2 VLA-3 and p 3 were moderately expressed on all tissues examined. The differential expression of molecules known to be involved in lymphocyte activation and adhesion in acute sympathetic ophthalmitis suggests that certain adhesion molecules play a role in the pathogenesis of intraocular inflammation and may be suitable targets for immunotherapy. |
| doi_str_mv | 10.3109/02713689309020399 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_4025716</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76174434</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-131b784f1dbae80b4f0e5cacd31df70312854b82992fd7f728f23f84b86551453</originalsourceid><addsrcrecordid>eNp9kEtLxDAUhYMoOo7-ABdCF-Kumldf6GYYfIHgRtflNr2hkbSpSYvOv7fjjIIIrhLO-c7l3kPICaMXgtHikvKMiTQvBC0op6IodsiMyZTGnFO-S2ZrP54AcUAOQ3ildC3IfbKf80KkaT4jD4u6wWBcF7XOohotRvjRewxfmukiUOOAEXR1pE3l3WBUFFZtD0OD67_rm6EB2xo4InsabMDj7TsnL7c3z8v7-PHp7mG5eIyVTIohZoJVWS41qyvAnFZSU0wUqFqwWmdUMJ4nspr2K7iuM53xXHOh80lKk4TJRMzJ-WZu793biGEoWxMUWgsdujGUWcoyKYWcQLYBlXcheNRl700LflUyWq7rK__UN2VOt8PHqsX6J7Hta_LPtj4EBVZ76JQJP5ikPMlYOmHXG8x02vkW3p23dTnAyjr_nRH_bXH1K94g2KFR4LF8daPvpnr_ueETNlecaQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76174434</pqid></control><display><type>article</type><title>Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Taylor & Francis Journals Complete</source><creator>Kuppner, M. C. ; Liversidge, J. ; McKillop-Smith, S. ; Lumsden, L. ; Forrester, J. V.</creator><creatorcontrib>Kuppner, M. C. ; Liversidge, J. ; McKillop-Smith, S. ; Lumsden, L. ; Forrester, J. V.</creatorcontrib><description>Samples of iris ciliary body, choroid and retina from normal eyes and from 2 cases of sympathetic ophthalmitis (one acute and one late stage fibrosis) were examined for the expression of the VLA integrins pl and a 1-6, and the integrin β3, in addition to ICAM-1, VCAM-1, ELAM-1 and CD44 using an APAAP staining technique.
The expression of VLA-4, VLA-5, VCAM-1, ICAM-1, and CD44 was significantly increased and ELAM-1 was slightly increased in acute sympathetic ophthalmitis in comparison to fibrotic and normal eyes.
VLA-6 was moderately increased in acute and fibrotic cases and VLA-2 VLA-3 and p 3 were moderately expressed on all tissues examined. The differential expression of molecules known to be involved in lymphocyte activation and adhesion in acute sympathetic ophthalmitis suggests that certain adhesion molecules play a role in the pathogenesis of intraocular inflammation and may be suitable targets for immunotherapy.</description><identifier>ISSN: 0271-3683</identifier><identifier>EISSN: 1460-2202</identifier><identifier>DOI: 10.3109/02713689309020399</identifier><identifier>PMID: 8293668</identifier><identifier>CODEN: CEYRDM</identifier><language>eng</language><publisher>Lisse: Informa UK Ltd</publisher><subject>Acute Disease ; Adult ; Aged ; Anterior Eye Segment - metabolism ; Biological and medical sciences ; Cell Adhesion Molecules - metabolism ; Choroid - metabolism ; Choroid - pathology ; Female ; Fibrosis ; Humans ; Immunoenzyme Techniques ; Lymphocytes - pathology ; Male ; Medical sciences ; Ophthalmia, Sympathetic - metabolism ; Ophthalmology ; Retina - metabolism ; Retina - pathology ; Uvea diseases</subject><ispartof>Current eye research, 1993, Vol.12 (10), p.923-934</ispartof><rights>1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-131b784f1dbae80b4f0e5cacd31df70312854b82992fd7f728f23f84b86551453</citedby><cites>FETCH-LOGICAL-c459t-131b784f1dbae80b4f0e5cacd31df70312854b82992fd7f728f23f84b86551453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02713689309020399$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02713689309020399$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4025716$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8293668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuppner, M. C.</creatorcontrib><creatorcontrib>Liversidge, J.</creatorcontrib><creatorcontrib>McKillop-Smith, S.</creatorcontrib><creatorcontrib>Lumsden, L.</creatorcontrib><creatorcontrib>Forrester, J. V.</creatorcontrib><title>Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia</title><title>Current eye research</title><addtitle>Curr Eye Res</addtitle><description>Samples of iris ciliary body, choroid and retina from normal eyes and from 2 cases of sympathetic ophthalmitis (one acute and one late stage fibrosis) were examined for the expression of the VLA integrins pl and a 1-6, and the integrin β3, in addition to ICAM-1, VCAM-1, ELAM-1 and CD44 using an APAAP staining technique.
The expression of VLA-4, VLA-5, VCAM-1, ICAM-1, and CD44 was significantly increased and ELAM-1 was slightly increased in acute sympathetic ophthalmitis in comparison to fibrotic and normal eyes.
VLA-6 was moderately increased in acute and fibrotic cases and VLA-2 VLA-3 and p 3 were moderately expressed on all tissues examined. The differential expression of molecules known to be involved in lymphocyte activation and adhesion in acute sympathetic ophthalmitis suggests that certain adhesion molecules play a role in the pathogenesis of intraocular inflammation and may be suitable targets for immunotherapy.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Anterior Eye Segment - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Choroid - metabolism</subject><subject>Choroid - pathology</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ophthalmia, Sympathetic - metabolism</subject><subject>Ophthalmology</subject><subject>Retina - metabolism</subject><subject>Retina - pathology</subject><subject>Uvea diseases</subject><issn>0271-3683</issn><issn>1460-2202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOo7-ABdCF-Kumldf6GYYfIHgRtflNr2hkbSpSYvOv7fjjIIIrhLO-c7l3kPICaMXgtHikvKMiTQvBC0op6IodsiMyZTGnFO-S2ZrP54AcUAOQ3ildC3IfbKf80KkaT4jD4u6wWBcF7XOohotRvjRewxfmukiUOOAEXR1pE3l3WBUFFZtD0OD67_rm6EB2xo4InsabMDj7TsnL7c3z8v7-PHp7mG5eIyVTIohZoJVWS41qyvAnFZSU0wUqFqwWmdUMJ4nspr2K7iuM53xXHOh80lKk4TJRMzJ-WZu793biGEoWxMUWgsdujGUWcoyKYWcQLYBlXcheNRl700LflUyWq7rK__UN2VOt8PHqsX6J7Hta_LPtj4EBVZ76JQJP5ikPMlYOmHXG8x02vkW3p23dTnAyjr_nRH_bXH1K94g2KFR4LF8daPvpnr_ueETNlecaQ</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Kuppner, M. C.</creator><creator>Liversidge, J.</creator><creator>McKillop-Smith, S.</creator><creator>Lumsden, L.</creator><creator>Forrester, J. V.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Swets & Zeitlinger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia</title><author>Kuppner, M. C. ; Liversidge, J. ; McKillop-Smith, S. ; Lumsden, L. ; Forrester, J. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-131b784f1dbae80b4f0e5cacd31df70312854b82992fd7f728f23f84b86551453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Anterior Eye Segment - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Choroid - metabolism</topic><topic>Choroid - pathology</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ophthalmia, Sympathetic - metabolism</topic><topic>Ophthalmology</topic><topic>Retina - metabolism</topic><topic>Retina - pathology</topic><topic>Uvea diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuppner, M. C.</creatorcontrib><creatorcontrib>Liversidge, J.</creatorcontrib><creatorcontrib>McKillop-Smith, S.</creatorcontrib><creatorcontrib>Lumsden, L.</creatorcontrib><creatorcontrib>Forrester, J. V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuppner, M. C.</au><au>Liversidge, J.</au><au>McKillop-Smith, S.</au><au>Lumsden, L.</au><au>Forrester, J. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia</atitle><jtitle>Current eye research</jtitle><addtitle>Curr Eye Res</addtitle><date>1993</date><risdate>1993</risdate><volume>12</volume><issue>10</issue><spage>923</spage><epage>934</epage><pages>923-934</pages><issn>0271-3683</issn><eissn>1460-2202</eissn><coden>CEYRDM</coden><abstract>Samples of iris ciliary body, choroid and retina from normal eyes and from 2 cases of sympathetic ophthalmitis (one acute and one late stage fibrosis) were examined for the expression of the VLA integrins pl and a 1-6, and the integrin β3, in addition to ICAM-1, VCAM-1, ELAM-1 and CD44 using an APAAP staining technique.
The expression of VLA-4, VLA-5, VCAM-1, ICAM-1, and CD44 was significantly increased and ELAM-1 was slightly increased in acute sympathetic ophthalmitis in comparison to fibrotic and normal eyes.
VLA-6 was moderately increased in acute and fibrotic cases and VLA-2 VLA-3 and p 3 were moderately expressed on all tissues examined. The differential expression of molecules known to be involved in lymphocyte activation and adhesion in acute sympathetic ophthalmitis suggests that certain adhesion molecules play a role in the pathogenesis of intraocular inflammation and may be suitable targets for immunotherapy.</abstract><cop>Lisse</cop><pub>Informa UK Ltd</pub><pmid>8293668</pmid><doi>10.3109/02713689309020399</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-3683 |
| ispartof | Current eye research, 1993, Vol.12 (10), p.923-934 |
| issn | 0271-3683 1460-2202 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_4025716 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Acute Disease Adult Aged Anterior Eye Segment - metabolism Biological and medical sciences Cell Adhesion Molecules - metabolism Choroid - metabolism Choroid - pathology Female Fibrosis Humans Immunoenzyme Techniques Lymphocytes - pathology Male Medical sciences Ophthalmia, Sympathetic - metabolism Ophthalmology Retina - metabolism Retina - pathology Uvea diseases |
| title | Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T03%3A58%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adhesion%20molecule%20expression%20in%20acute%20and%20fibrotic%20sympathetic%20ophthalmia&rft.jtitle=Current%20eye%20research&rft.au=Kuppner,%20M.%20C.&rft.date=1993&rft.volume=12&rft.issue=10&rft.spage=923&rft.epage=934&rft.pages=923-934&rft.issn=0271-3683&rft.eissn=1460-2202&rft.coden=CEYRDM&rft_id=info:doi/10.3109/02713689309020399&rft_dat=%3Cproquest_pasca%3E76174434%3C/proquest_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76174434&rft_id=info:pmid/8293668&rfr_iscdi=true |