Opiate-Like Substances in an Invertebrate, an Opiate Receptor on Invertebrate and Human Immunocytes, and a Role in Immunosuppression

The presence of morphine-like and codeine-like substances was demonstrated in the pedal ganglia, hemolymph, and mantle tissues of the mollusc Mytilus edulis. The pharmacological activities of the endogenous morphine-like material resemble those of authentic morphine. Both substances were found to co...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-12, Vol.90 (23), p.11099-11103
Hauptverfasser:	Stefano, George B., Digenis, Alex, Spector, Sydney, Leung, Michael K., Bilfinger, Thomas V., Makman, Maynard H., Scharrer, Berta, Abumrad, Naji N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Biochemistry. Physiology. Immunology Biological and medical sciences Bivalvia - physiology Chemotaxis, Leukocyte - drug effects Drugs Fundamental and applied biological sciences. Psychology Ganglia Ganglia, Invertebrate - chemistry Hemolymph Hemolymph - chemistry Humans Immunity (Disease) Immunocytes In Vitro Techniques Invertebrates Ligands Marine Mollusca Mollusks Monocytes Monocytes - physiology Morphine Morphine - pharmacology Mytilus edulis Narcotics - pharmacology Opiates Opioid receptors Physiology. Development Receptors Receptors, Opioid - physiology Stress, Physiological - physiopathology
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