Involvement of the Renin Angiotensin System in the Pathogenesis of Postexercise Proteinuria
Proteinuria after strenuous exercise is common in healthy subjects. The pathophysiologic mechanism of postexercise proteinuria (PEP) is not clear, although the phenomenon has long been known and many explanatory theories have been proposed. It is widely recognized that angiotensin II may increase fi...
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| Veröffentlicht in: | Scandinavian journal of urology and nephrology 1993-09, Vol.27 (3), p.301-304 |
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| container_title | Scandinavian journal of urology and nephrology |
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| creator | Cosenzi, Alessandro Carraro, Michele Sacerdote, Ariela Franca, Giuliano Piemontesi, Annamaria Bocin, Elena Faccini, Luigi Bellini, Giuseppe |
| description | Proteinuria after strenuous exercise is common in healthy subjects. The pathophysiologic mechanism of postexercise proteinuria (PEP) is not clear, although the phenomenon has long been known and many explanatory theories have been proposed. It is widely recognized that angiotensin II may increase filtration of protein through the glomerular membrane, and that its concentration in plasma increases during exercise. The aim of this study was to evaluate possible involvement of angiotensin II in the pathogenesis of PEP. Of 25 young volunteers who performed maximal aerobic exercise, eight showed PEP. The exercise was repeated after an interval of at least one week, now 90 minutes after administration of captopril (25 mg). Captopril did not affect the achieved work load of the maximal blood pressure and heart rate during the exercise, but PEP was not found. As it was possible to prevent PEP by administering an angiotensin-converting enzyme inhibitor, the study supports the theory that the renin angiotensin system is involved in the pathogenesis of PEP. |
| doi_str_mv | 10.3109/00365599309180438 |
| format | Article |
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The pathophysiologic mechanism of postexercise proteinuria (PEP) is not clear, although the phenomenon has long been known and many explanatory theories have been proposed. It is widely recognized that angiotensin II may increase filtration of protein through the glomerular membrane, and that its concentration in plasma increases during exercise. The aim of this study was to evaluate possible involvement of angiotensin II in the pathogenesis of PEP. Of 25 young volunteers who performed maximal aerobic exercise, eight showed PEP. The exercise was repeated after an interval of at least one week, now 90 minutes after administration of captopril (25 mg). Captopril did not affect the achieved work load of the maximal blood pressure and heart rate during the exercise, but PEP was not found. As it was possible to prevent PEP by administering an angiotensin-converting enzyme inhibitor, the study supports the theory that the renin angiotensin system is involved in the pathogenesis of PEP.</description><identifier>ISSN: 0036-5599</identifier><identifier>EISSN: 1651-2065</identifier><identifier>DOI: 10.3109/00365599309180438</identifier><identifier>PMID: 8290907</identifier><identifier>CODEN: SJUNAS</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>ACE inhibitor ; Adult ; Angiotensin II - physiology ; Biological and medical sciences ; Captopril ; Exercise - physiology ; Exercise Test ; Female ; Humans ; Kidneys ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; postexercise proteinuria ; Proteinuria - etiology ; Proteinuria - physiopathology ; renin-angiotensin system ; Renin-Angiotensin System - physiology ; Urinary system involvement in other diseases. 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The pathophysiologic mechanism of postexercise proteinuria (PEP) is not clear, although the phenomenon has long been known and many explanatory theories have been proposed. It is widely recognized that angiotensin II may increase filtration of protein through the glomerular membrane, and that its concentration in plasma increases during exercise. The aim of this study was to evaluate possible involvement of angiotensin II in the pathogenesis of PEP. Of 25 young volunteers who performed maximal aerobic exercise, eight showed PEP. The exercise was repeated after an interval of at least one week, now 90 minutes after administration of captopril (25 mg). Captopril did not affect the achieved work load of the maximal blood pressure and heart rate during the exercise, but PEP was not found. As it was possible to prevent PEP by administering an angiotensin-converting enzyme inhibitor, the study supports the theory that the renin angiotensin system is involved in the pathogenesis of PEP.</description><subject>ACE inhibitor</subject><subject>Adult</subject><subject>Angiotensin II - physiology</subject><subject>Biological and medical sciences</subject><subject>Captopril</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>postexercise proteinuria</subject><subject>Proteinuria - etiology</subject><subject>Proteinuria - physiopathology</subject><subject>renin-angiotensin system</subject><subject>Renin-Angiotensin System - physiology</subject><subject>Urinary system involvement in other diseases. 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Urinary tract diseases</topic><topic>postexercise proteinuria</topic><topic>Proteinuria - etiology</topic><topic>Proteinuria - physiopathology</topic><topic>renin-angiotensin system</topic><topic>Renin-Angiotensin System - physiology</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>online_resources</toplevel><creatorcontrib>Cosenzi, Alessandro</creatorcontrib><creatorcontrib>Carraro, Michele</creatorcontrib><creatorcontrib>Sacerdote, Ariela</creatorcontrib><creatorcontrib>Franca, Giuliano</creatorcontrib><creatorcontrib>Piemontesi, Annamaria</creatorcontrib><creatorcontrib>Bocin, Elena</creatorcontrib><creatorcontrib>Faccini, Luigi</creatorcontrib><creatorcontrib>Bellini, Giuseppe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cosenzi, Alessandro</au><au>Carraro, Michele</au><au>Sacerdote, Ariela</au><au>Franca, Giuliano</au><au>Piemontesi, Annamaria</au><au>Bocin, Elena</au><au>Faccini, Luigi</au><au>Bellini, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of the Renin Angiotensin System in the Pathogenesis of Postexercise Proteinuria</atitle><jtitle>Scandinavian journal of urology and nephrology</jtitle><addtitle>Scand J Urol Nephrol</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>27</volume><issue>3</issue><spage>301</spage><epage>304</epage><pages>301-304</pages><issn>0036-5599</issn><eissn>1651-2065</eissn><coden>SJUNAS</coden><abstract>Proteinuria after strenuous exercise is common in healthy subjects. The pathophysiologic mechanism of postexercise proteinuria (PEP) is not clear, although the phenomenon has long been known and many explanatory theories have been proposed. It is widely recognized that angiotensin II may increase filtration of protein through the glomerular membrane, and that its concentration in plasma increases during exercise. The aim of this study was to evaluate possible involvement of angiotensin II in the pathogenesis of PEP. Of 25 young volunteers who performed maximal aerobic exercise, eight showed PEP. The exercise was repeated after an interval of at least one week, now 90 minutes after administration of captopril (25 mg). Captopril did not affect the achieved work load of the maximal blood pressure and heart rate during the exercise, but PEP was not found. As it was possible to prevent PEP by administering an angiotensin-converting enzyme inhibitor, the study supports the theory that the renin angiotensin system is involved in the pathogenesis of PEP.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>8290907</pmid><doi>10.3109/00365599309180438</doi><tpages>4</tpages></addata></record> |
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| ispartof | Scandinavian journal of urology and nephrology, 1993-09, Vol.27 (3), p.301-304 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | ACE inhibitor Adult Angiotensin II - physiology Biological and medical sciences Captopril Exercise - physiology Exercise Test Female Humans Kidneys Male Medical sciences Nephrology. Urinary tract diseases postexercise proteinuria Proteinuria - etiology Proteinuria - physiopathology renin-angiotensin system Renin-Angiotensin System - physiology Urinary system involvement in other diseases. Miscellaneous |
| title | Involvement of the Renin Angiotensin System in the Pathogenesis of Postexercise Proteinuria |
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