A Selective N-Type Calcium Channel Antagonist Protects Against Neuronal Loss After Global Cerebral Ischemia

Calcium influx is believed to play a critical role in the cascade of biochemical events leading to neuronal cell death in a variety of pathological settings, including cerebral ischemia. The synthetic ω-conotoxin peptide SNX-111, which selectively blocks depolarization-induced calcium fluxes through...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-08, Vol.90 (16), p.7894-7897
Hauptverfasser:	Valentino, K., Newcomb, R., Gadbois, T., Singh, T., Bowersox, S., Bitner, S., Justice, A., Yamashiro, D., Hoffman, B. B., Ciaranello, R., Miljanich, G., Ramachandran, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and medical sciences Brain damage Calcium Calcium Channels - drug effects Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Drug Administration Schedule Forebrain Glutamates - metabolism Glutamic Acid Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Human resources Intravenous injections Ischemia Ischemic Attack, Transient - pathology Ischemic Attack, Transient - physiopathology Male Medical sciences Neurology Neurons Neurons - drug effects Neurons - pathology Neuropharmacology Neuroprotective agent Neuroscience omega-Conotoxins Peptides - chemical synthesis Peptides - pharmacology Pharmacology. Drug treatments Potassium - pharmacology Prosencephalon - drug effects Prosencephalon - pathology Pyramidal Tracts - drug effects Pyramidal Tracts - metabolism Pyramidal Tracts - pathology Rats Rats, Inbred F344 Reperfusion Time Factors Wildlife damage management
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