Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc
A simple, rapid, and accurate method for the determination of naphazoline, oxymetazoline, xylometazoline, and ephedrine in rinological solutions using reversed-phase HPLC was developed. It involves the use of alumina coated with polybutadiene as the stationary phase, acetonitrile-aqueous 10 −3 M NaO...
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| Veröffentlicht in: | Journal of liquid chromatography 1995-09, Vol.18 (16), p.3233-3242 |
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| container_issue | 16 |
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| container_title | Journal of liquid chromatography |
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| creator | De Orsi, D. Gagliardi, L. Cavazzutti, G. Mediati, M. G. Tonelli, D. |
| description | A simple, rapid, and accurate method for the determination of naphazoline, oxymetazoline, xylometazoline, and ephedrine in rinological solutions using reversed-phase HPLC was developed. It involves the use of alumina coated with polybutadiene as the stationary phase, acetonitrile-aqueous 10
−3
M NaOH (10:90) as the initial mobile phase with a linear gradient from 10 to 80% acetonitrile in 25 min, and detection at 224 nm. The only sample preparation is its dilution with water. Linearity and precision of the method have been assessed. The assay results obtained for various formulations were in agreement with the declared amounts. |
| doi_str_mv | 10.1080/10826079508010447 |
| format | Article |
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−3
M NaOH (10:90) as the initial mobile phase with a linear gradient from 10 to 80% acetonitrile in 25 min, and detection at 224 nm. The only sample preparation is its dilution with water. Linearity and precision of the method have been assessed. The assay results obtained for various formulations were in agreement with the declared amounts.</description><identifier>ISSN: 0148-3919</identifier><identifier>EISSN: 2331-0413</identifier><identifier>DOI: 10.1080/10826079508010447</identifier><identifier>CODEN: JLCHD8</identifier><language>eng</language><publisher>New York, NY: Taylor & Francis Group</publisher><subject>Analysis ; Biological and medical sciences ; General pharmacology ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Journal of liquid chromatography, 1995-09, Vol.18 (16), p.3233-3242</ispartof><rights>Copyright Taylor & Francis Group, LLC 1995</rights><rights>1995 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-86d9d565b3199aab2ea5fbe9ba7b383bc066ae5a2716f5c5bd2908706d468bc3</citedby><cites>FETCH-LOGICAL-c391t-86d9d565b3199aab2ea5fbe9ba7b383bc066ae5a2716f5c5bd2908706d468bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10826079508010447$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10826079508010447$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,60436</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3681530$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>De Orsi, D.</creatorcontrib><creatorcontrib>Gagliardi, L.</creatorcontrib><creatorcontrib>Cavazzutti, G.</creatorcontrib><creatorcontrib>Mediati, M. G.</creatorcontrib><creatorcontrib>Tonelli, D.</creatorcontrib><title>Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc</title><title>Journal of liquid chromatography</title><description>A simple, rapid, and accurate method for the determination of naphazoline, oxymetazoline, xylometazoline, and ephedrine in rinological solutions using reversed-phase HPLC was developed. It involves the use of alumina coated with polybutadiene as the stationary phase, acetonitrile-aqueous 10
−3
M NaOH (10:90) as the initial mobile phase with a linear gradient from 10 to 80% acetonitrile in 25 min, and detection at 224 nm. The only sample preparation is its dilution with water. Linearity and precision of the method have been assessed. The assay results obtained for various formulations were in agreement with the declared amounts.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0148-3919</issn><issn>2331-0413</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LAzEQxYMoWLQfwFsOXleTzSa7AS9SW1soKNr7MvmzNLKbXZKtUj-90aoXMYcJGd7vTd4gdEHJFSUVuU4lF6SUPD0oKYryCE1yxmhGCsqO0YTQosqYpPIUTWN8IenwoixENUHDs-t27Qje9ruI7-xoQ-c8jK73uG_wfNhaE5y3GLzBebbqnIH3vk2diJ3Hj1sIHWi7G52GFi_6kNy-6IjVHj_ZVxuiNVnSRYuXQ6vP0UkDbbTT7_sMbRbzzWyZrR_uV7PbdabTR8esEkYaLrhiVEoAlVvgjbJSQalYxZQmQoDlkJdUNFxzZXJJqpIIk2Ipzc4QPdjq0McYbFMPwXUQ9jUl9efS6j9LS8zlgRkgpjRNAK9d_AWZqChnJMluDjLnm5QX3vrQmnqEfduHH4b9P-UDg4eARg</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>De Orsi, D.</creator><creator>Gagliardi, L.</creator><creator>Cavazzutti, G.</creator><creator>Mediati, M. G.</creator><creator>Tonelli, D.</creator><general>Taylor & Francis Group</general><general>Dekker</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19950901</creationdate><title>Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc</title><author>De Orsi, D. ; Gagliardi, L. ; Cavazzutti, G. ; Mediati, M. G. ; Tonelli, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-86d9d565b3199aab2ea5fbe9ba7b383bc066ae5a2716f5c5bd2908706d468bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>online_resources</toplevel><creatorcontrib>De Orsi, D.</creatorcontrib><creatorcontrib>Gagliardi, L.</creatorcontrib><creatorcontrib>Cavazzutti, G.</creatorcontrib><creatorcontrib>Mediati, M. G.</creatorcontrib><creatorcontrib>Tonelli, D.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of liquid chromatography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Orsi, D.</au><au>Gagliardi, L.</au><au>Cavazzutti, G.</au><au>Mediati, M. G.</au><au>Tonelli, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc</atitle><jtitle>Journal of liquid chromatography</jtitle><date>1995-09-01</date><risdate>1995</risdate><volume>18</volume><issue>16</issue><spage>3233</spage><epage>3242</epage><pages>3233-3242</pages><issn>0148-3919</issn><eissn>2331-0413</eissn><coden>JLCHD8</coden><abstract>A simple, rapid, and accurate method for the determination of naphazoline, oxymetazoline, xylometazoline, and ephedrine in rinological solutions using reversed-phase HPLC was developed. It involves the use of alumina coated with polybutadiene as the stationary phase, acetonitrile-aqueous 10
−3
M NaOH (10:90) as the initial mobile phase with a linear gradient from 10 to 80% acetonitrile in 25 min, and detection at 224 nm. The only sample preparation is its dilution with water. Linearity and precision of the method have been assessed. The assay results obtained for various formulations were in agreement with the declared amounts.</abstract><cop>New York, NY</cop><pub>Taylor & Francis Group</pub><doi>10.1080/10826079508010447</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of liquid chromatography, 1995-09, Vol.18 (16), p.3233-3242 |
| issn | 0148-3919 2331-0413 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_3681530 |
| source | Taylor & Francis:Master (3349 titles) |
| subjects | Analysis Biological and medical sciences General pharmacology Medical sciences Pharmacology. Drug treatments |
| title | Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc |
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