HPLC Resolution of Hydroxyl Carboxylic Acid Enantiomers Using 2-Quinoxaloyl Chloride as a New Precolumn Derivatizing Agent

HPLC Resolution of Hydroxyl Carboxylic Acid Enantiomers Using 2-Quinoxaloyl Chloride as a New Precolumn Derivatizing Agent

Chiral α-hydroxy carboxylic acids were reacted using 2-quinoxaloyl chloride to form UV and fluorescent derivatives. Under mild conditions either in aqueous or non-aqueous conditions reaction proceeds quickly and without racemisation. The labelled compounds have been resolved into enantiomers on β-cy...

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Veröffentlicht in:Journal of liquid chromatography 1995-08, Vol.18 (14), p.2765-2781
Hauptverfasser: Brightwell, Malcolm, Pawlowska, Maria, Zukowski, Janusz
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Sprache:eng
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Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Other chromatographic methods
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container_end_page 2781
container_issue 14
container_start_page 2765
container_title Journal of liquid chromatography
container_volume 18
creator Brightwell, Malcolm
Pawlowska, Maria
Zukowski, Janusz
description Chiral α-hydroxy carboxylic acids were reacted using 2-quinoxaloyl chloride to form UV and fluorescent derivatives. Under mild conditions either in aqueous or non-aqueous conditions reaction proceeds quickly and without racemisation. The labelled compounds have been resolved into enantiomers on β-cyclodextrin bonded stationary phase operated with polar organic eluents. The high sensitivity and selectivity of the method has been used for the determination of low levels of enantiomeric impurities in commercial "pure" samples.
doi_str_mv 10.1080/10826079508009323
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source Taylor & Francis:Master (3349 titles)
subjects Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Other chromatographic methods
title HPLC Resolution of Hydroxyl Carboxylic Acid Enantiomers Using 2-Quinoxaloyl Chloride as a New Precolumn Derivatizing Agent
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