Relationship between α1‐antitrypsin inactivation and tumor necrosis factor α concentration in the synovial fluid of patients with rheumatoid arthritis
Objective. To examine the relationship between α1‐antitrypsin (α1AT) specific activity and tumor necrosis factor α (TNFα) concentration in synovial fluid from 48 patients with rheumatoid arthritis. Methods. The specific activity of α1AT was calculated from the measurement of α1AT concentration (by r...
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| Veröffentlicht in: | Arthritis and rheumatism 1994-12, Vol.37 (12), p.1723-1726 |
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| container_issue | 12 |
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| container_title | Arthritis and rheumatism |
| container_volume | 37 |
| creator | Chidwick, Keith Whichelow, Catherine E. Zhang, Zhi Fairburn, Kevin Sachs, John A. Blake, David R. Winyard, Paul G. |
| description | Objective. To examine the relationship between α1‐antitrypsin (α1AT) specific activity and tumor necrosis factor α (TNFα) concentration in synovial fluid from 48 patients with rheumatoid arthritis.
Methods. The specific activity of α1AT was calculated from the measurement of α1AT concentration (by rocket immunoelectrophoresis) and elastase inhibitory capacity. TNFα was detected by enzyme‐linked immuno‐sorbent assay.
Results. TNFα concentrations correlated with the extent of α1AT inactivation.
Conclusion. Our findings are consistent with a role of elastase in TNFα release within the inflamed joint. |
| doi_str_mv | 10.1002/art.1780371203 |
| format | Article |
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Methods. The specific activity of α1AT was calculated from the measurement of α1AT concentration (by rocket immunoelectrophoresis) and elastase inhibitory capacity. TNFα was detected by enzyme‐linked immuno‐sorbent assay.
Results. TNFα concentrations correlated with the extent of α1AT inactivation.
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Methods. The specific activity of α1AT was calculated from the measurement of α1AT concentration (by rocket immunoelectrophoresis) and elastase inhibitory capacity. TNFα was detected by enzyme‐linked immuno‐sorbent assay.
Results. TNFα concentrations correlated with the extent of α1AT inactivation.
Conclusion. Our findings are consistent with a role of elastase in TNFα release within the inflamed joint.</description><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Inflammatory joint diseases</subject><subject>Medical sciences</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNpFkM1KAzEURoMoWKtb11m4Hc2dzDSZZRH_oCBIXQ-3k4SJTDNDklq68xFc-xZ9kT6ET2K0oqvwcc695H6EnAO7BMbyK_TxEoRkXEDO-AEZQZlXGQMOh2TEGCsyXlZwTE5CeEkx5yUfkY8n3WG0vQutHehCx7XWju628Pn2ji7a6DdDsI5ah020rz8qRadoXC17T51ufB9soCbhlHdb2vSu0S76vZpGY6tp2Lj-1WJHTbeyivaGDoknLdC1jS31rV4tMfaJpTNab6MNp-TIYBf02e87Js-3N_Pr-2z2ePdwPZ1lAxSCZwqVqRggCCPZRJWFVAC6WTCpDeaVkROsRGGkylkhUj2gUEquJ6rQJYhFxcfkYr93wNBgZzy6xoZ68HaJflNzzoWYyKRVe21tO735w8Dq7_br9O36v_16-jT_T_wLSG6CZw</recordid><startdate>199412</startdate><enddate>199412</enddate><creator>Chidwick, Keith</creator><creator>Whichelow, Catherine E.</creator><creator>Zhang, Zhi</creator><creator>Fairburn, Kevin</creator><creator>Sachs, John A.</creator><creator>Blake, David R.</creator><creator>Winyard, Paul G.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>IQODW</scope></search><sort><creationdate>199412</creationdate><title>Relationship between α1‐antitrypsin inactivation and tumor necrosis factor α concentration in the synovial fluid of patients with rheumatoid arthritis</title><author>Chidwick, Keith ; Whichelow, Catherine E. ; Zhang, Zhi ; Fairburn, Kevin ; Sachs, John A. ; Blake, David R. ; Winyard, Paul G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1473-dadf901a17f806d548d11ecb08efa29f86a974f8d20477801da883e6d4e517b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Inflammatory joint diseases</topic><topic>Medical sciences</topic><toplevel>online_resources</toplevel><creatorcontrib>Chidwick, Keith</creatorcontrib><creatorcontrib>Whichelow, Catherine E.</creatorcontrib><creatorcontrib>Zhang, Zhi</creatorcontrib><creatorcontrib>Fairburn, Kevin</creatorcontrib><creatorcontrib>Sachs, John A.</creatorcontrib><creatorcontrib>Blake, David R.</creatorcontrib><creatorcontrib>Winyard, Paul G.</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chidwick, Keith</au><au>Whichelow, Catherine E.</au><au>Zhang, Zhi</au><au>Fairburn, Kevin</au><au>Sachs, John A.</au><au>Blake, David R.</au><au>Winyard, Paul G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between α1‐antitrypsin inactivation and tumor necrosis factor α concentration in the synovial fluid of patients with rheumatoid arthritis</atitle><jtitle>Arthritis and rheumatism</jtitle><date>1994-12</date><risdate>1994</risdate><volume>37</volume><issue>12</issue><spage>1723</spage><epage>1726</epage><pages>1723-1726</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>Objective. To examine the relationship between α1‐antitrypsin (α1AT) specific activity and tumor necrosis factor α (TNFα) concentration in synovial fluid from 48 patients with rheumatoid arthritis.
Methods. The specific activity of α1AT was calculated from the measurement of α1AT concentration (by rocket immunoelectrophoresis) and elastase inhibitory capacity. TNFα was detected by enzyme‐linked immuno‐sorbent assay.
Results. TNFα concentrations correlated with the extent of α1AT inactivation.
Conclusion. Our findings are consistent with a role of elastase in TNFα release within the inflamed joint.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/art.1780371203</doi><tpages>4</tpages></addata></record> |
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| ispartof | Arthritis and rheumatism, 1994-12, Vol.37 (12), p.1723-1726 |
| issn | 0004-3591 1529-0131 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_3337768 |
| source | Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Diseases of the osteoarticular system Inflammatory joint diseases Medical sciences |
| title | Relationship between α1‐antitrypsin inactivation and tumor necrosis factor α concentration in the synovial fluid of patients with rheumatoid arthritis |
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