Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men
D. R. Dengel, R. E. Pratley, J. M. Hagberg, E. M. Rogus and A. P. Goldberg Department of Medicine, University of Maryland School of Medicine, Baltimore, USA. The decline in glucose homeostasis with aging may be due to the physical deconditioning and obesity that often develop with aging. The indepen...
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creator | Dengel, D. R Pratley, R. E Hagberg, J. M Rogus, E. M Goldberg, A. P |
description | D. R. Dengel, R. E. Pratley, J. M. Hagberg, E. M. Rogus and A. P. Goldberg
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA.
The decline in glucose homeostasis with aging may be due to the physical
deconditioning and obesity that often develop with aging. The independent
and combined effects of aerobic exercise training (AEX) and weight loss
(WL) on glucose metabolism were studied in 47 nondiabetic sedentary older
men. There were 14 men in a weekly behavioral modification/WL program, 10
in a 3 times/wk AEX program, 14 in an AEX+WL program, and 9 in the control
(Con) group. The 10-mo intervention increased maximal oxygen consumption
(VO2max) in both the AEX and AEX+WL groups [0.33 +/- 0.05 and 0.37 +/- 0.09
(SE) l/min, respectively], but VO2max did not significantly change in the
WL (0.01 +/- 0.06 l/min) and Con groups (-0.04 +/- 0.05 l/min; P >
0.05). The AEX+WL and WL groups had comparable reductions in body weight
(-8.5 +/- 0.9 and -8.8 +/- 1.2 kg, respectively) and percent fat (-5.5 +/-
0.7 and -5.9 +/- 1.1%, respectively) that were significantly greater than
those in the Con and AEX groups. Oral glucose tolerance tests showed
significant reductions in insulin responses in the AEX, WL, and AEX+WL
groups, but the decrease in insulin response in the AEX+WL group was
significantly greater than that in the other three groups. The glucose area
decreased significantly in the WL and AEX+WL groups but did not change in
the Con or AEX groups. There were significant increases in insulin-mediated
glucose disposal rates as measured by the hyperinsulinemic (600
pmol.m-2.min-1) euglycemic clamps in the AEX and AEX+WL groups [1.66 +/-
0.50 and 1.76 +/- 0.41 mg.kg fat-free mass (FFM)-1.min-1, respectively]
that were significantly greater than those in the WL (0.13 +/- 0.31 mg.kg
FFM-1.min-1) and Con groups (-0.05 +/- 0.51 mg.kg FFM-1.min-1; n = 5).
These data suggest that AEX and WL improve glucose metabolism through
different mechanisms and that the combined intervention of AEX+WL is
necessary to improve both glucose tolerance and insulin sensitivity in
older men. |
doi_str_mv | 10.1152/jappl.1996.81.1.318 |
format | Article |
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Department of Medicine, University of Maryland School of Medicine, Baltimore, USA.
The decline in glucose homeostasis with aging may be due to the physical
deconditioning and obesity that often develop with aging. The independent
and combined effects of aerobic exercise training (AEX) and weight loss
(WL) on glucose metabolism were studied in 47 nondiabetic sedentary older
men. There were 14 men in a weekly behavioral modification/WL program, 10
in a 3 times/wk AEX program, 14 in an AEX+WL program, and 9 in the control
(Con) group. The 10-mo intervention increased maximal oxygen consumption
(VO2max) in both the AEX and AEX+WL groups [0.33 +/- 0.05 and 0.37 +/- 0.09
(SE) l/min, respectively], but VO2max did not significantly change in the
WL (0.01 +/- 0.06 l/min) and Con groups (-0.04 +/- 0.05 l/min; P >
0.05). The AEX+WL and WL groups had comparable reductions in body weight
(-8.5 +/- 0.9 and -8.8 +/- 1.2 kg, respectively) and percent fat (-5.5 +/-
0.7 and -5.9 +/- 1.1%, respectively) that were significantly greater than
those in the Con and AEX groups. Oral glucose tolerance tests showed
significant reductions in insulin responses in the AEX, WL, and AEX+WL
groups, but the decrease in insulin response in the AEX+WL group was
significantly greater than that in the other three groups. The glucose area
decreased significantly in the WL and AEX+WL groups but did not change in
the Con or AEX groups. There were significant increases in insulin-mediated
glucose disposal rates as measured by the hyperinsulinemic (600
pmol.m-2.min-1) euglycemic clamps in the AEX and AEX+WL groups [1.66 +/-
0.50 and 1.76 +/- 0.41 mg.kg fat-free mass (FFM)-1.min-1, respectively]
that were significantly greater than those in the WL (0.13 +/- 0.31 mg.kg
FFM-1.min-1) and Con groups (-0.05 +/- 0.51 mg.kg FFM-1.min-1; n = 5).
These data suggest that AEX and WL improve glucose metabolism through
different mechanisms and that the combined intervention of AEX+WL is
necessary to improve both glucose tolerance and insulin sensitivity in
older men.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1996.81.1.318</identifier><identifier>PMID: 8828680</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Anaerobic Threshold - physiology ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Composition - physiology ; Diet, Reducing ; Exercise - physiology ; Glucose - metabolism ; Glucose Clamp Technique ; Glucose Tolerance Test ; Homeostasis - physiology ; Humans ; Insulin Resistance - physiology ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Obesity ; Obesity - metabolism ; Obesity - physiopathology ; Oxygen Consumption - physiology ; Physical Fitness ; Weight Loss - physiology</subject><ispartof>Journal of applied physiology (1985), 1996-07, Vol.81 (1), p.318-325</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-f175d35695b7e068962660b68643728ec41ea7115d499a3be578c9e9e527a7e73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3040,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3198281$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8828680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dengel, D. R</creatorcontrib><creatorcontrib>Pratley, R. E</creatorcontrib><creatorcontrib>Hagberg, J. M</creatorcontrib><creatorcontrib>Rogus, E. M</creatorcontrib><creatorcontrib>Goldberg, A. P</creatorcontrib><title>Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>D. R. Dengel, R. E. Pratley, J. M. Hagberg, E. M. Rogus and A. P. Goldberg
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA.
The decline in glucose homeostasis with aging may be due to the physical
deconditioning and obesity that often develop with aging. The independent
and combined effects of aerobic exercise training (AEX) and weight loss
(WL) on glucose metabolism were studied in 47 nondiabetic sedentary older
men. There were 14 men in a weekly behavioral modification/WL program, 10
in a 3 times/wk AEX program, 14 in an AEX+WL program, and 9 in the control
(Con) group. The 10-mo intervention increased maximal oxygen consumption
(VO2max) in both the AEX and AEX+WL groups [0.33 +/- 0.05 and 0.37 +/- 0.09
(SE) l/min, respectively], but VO2max did not significantly change in the
WL (0.01 +/- 0.06 l/min) and Con groups (-0.04 +/- 0.05 l/min; P >
0.05). The AEX+WL and WL groups had comparable reductions in body weight
(-8.5 +/- 0.9 and -8.8 +/- 1.2 kg, respectively) and percent fat (-5.5 +/-
0.7 and -5.9 +/- 1.1%, respectively) that were significantly greater than
those in the Con and AEX groups. Oral glucose tolerance tests showed
significant reductions in insulin responses in the AEX, WL, and AEX+WL
groups, but the decrease in insulin response in the AEX+WL group was
significantly greater than that in the other three groups. The glucose area
decreased significantly in the WL and AEX+WL groups but did not change in
the Con or AEX groups. There were significant increases in insulin-mediated
glucose disposal rates as measured by the hyperinsulinemic (600
pmol.m-2.min-1) euglycemic clamps in the AEX and AEX+WL groups [1.66 +/-
0.50 and 1.76 +/- 0.41 mg.kg fat-free mass (FFM)-1.min-1, respectively]
that were significantly greater than those in the WL (0.13 +/- 0.31 mg.kg
FFM-1.min-1) and Con groups (-0.05 +/- 0.51 mg.kg FFM-1.min-1; n = 5).
These data suggest that AEX and WL improve glucose metabolism through
different mechanisms and that the combined intervention of AEX+WL is
necessary to improve both glucose tolerance and insulin sensitivity in
older men.</description><subject>Anaerobic Threshold - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Composition - physiology</subject><subject>Diet, Reducing</subject><subject>Exercise - physiology</subject><subject>Glucose - metabolism</subject><subject>Glucose Clamp Technique</subject><subject>Glucose Tolerance Test</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Obesity - physiopathology</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical Fitness</subject><subject>Weight Loss - physiology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAQhi1EVZbCL0BIPiA4JXiS-CNH1PJRqVIvcLYcZ7LrktjB9qrdf4-XXZXTSPM-M2M_hLwDVgPw5vODWde5hr4XtYIa6hbUC7IpSVOBYPCSbJTkrJJcyVfkdUoPjEHXcbgkl0o1Sii2Ib9vXMrO20xxmtDmRMNEDcYwOEvxCaN1CWmOxnnnt9T4kT6i2-4ynUMqsKfbeW9DYXZhwZCySS5R52kYsDQTjuiziQe6oH9DLiYzJ3x7rlfk17evP69_VHf332-vv9xVtmtkriaQfGy56PkgkQnVi0YINgglulY2Cm0HaGQxMHZ9b9oBuVS2xx55I41E2V6Rj6e9awx_9piyXlyyOM_GY9gnLVUrmWC8gO0JtLF8JuKk1-iW8loNTB8V63-K9VGxVqBBF8Vl6v15_X5YcHyeOTst-YdzbpI18xSNLxKfsRb6AkLBPp2wXdH56CLqdXdILsxhezje_X_wL3PnlDE</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Dengel, D. R</creator><creator>Pratley, R. E</creator><creator>Hagberg, J. M</creator><creator>Rogus, E. M</creator><creator>Goldberg, A. P</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men</title><author>Dengel, D. R ; Pratley, R. E ; Hagberg, J. M ; Rogus, E. M ; Goldberg, A. P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-f175d35695b7e068962660b68643728ec41ea7115d499a3be578c9e9e527a7e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Anaerobic Threshold - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Composition - physiology</topic><topic>Diet, Reducing</topic><topic>Exercise - physiology</topic><topic>Glucose - metabolism</topic><topic>Glucose Clamp Technique</topic><topic>Glucose Tolerance Test</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Obesity - physiopathology</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical Fitness</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dengel, D. R</creatorcontrib><creatorcontrib>Pratley, R. E</creatorcontrib><creatorcontrib>Hagberg, J. M</creatorcontrib><creatorcontrib>Rogus, E. M</creatorcontrib><creatorcontrib>Goldberg, A. P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dengel, D. R</au><au>Pratley, R. E</au><au>Hagberg, J. M</au><au>Rogus, E. M</au><au>Goldberg, A. P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>81</volume><issue>1</issue><spage>318</spage><epage>325</epage><pages>318-325</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>D. R. Dengel, R. E. Pratley, J. M. Hagberg, E. M. Rogus and A. P. Goldberg
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA.
The decline in glucose homeostasis with aging may be due to the physical
deconditioning and obesity that often develop with aging. The independent
and combined effects of aerobic exercise training (AEX) and weight loss
(WL) on glucose metabolism were studied in 47 nondiabetic sedentary older
men. There were 14 men in a weekly behavioral modification/WL program, 10
in a 3 times/wk AEX program, 14 in an AEX+WL program, and 9 in the control
(Con) group. The 10-mo intervention increased maximal oxygen consumption
(VO2max) in both the AEX and AEX+WL groups [0.33 +/- 0.05 and 0.37 +/- 0.09
(SE) l/min, respectively], but VO2max did not significantly change in the
WL (0.01 +/- 0.06 l/min) and Con groups (-0.04 +/- 0.05 l/min; P >
0.05). The AEX+WL and WL groups had comparable reductions in body weight
(-8.5 +/- 0.9 and -8.8 +/- 1.2 kg, respectively) and percent fat (-5.5 +/-
0.7 and -5.9 +/- 1.1%, respectively) that were significantly greater than
those in the Con and AEX groups. Oral glucose tolerance tests showed
significant reductions in insulin responses in the AEX, WL, and AEX+WL
groups, but the decrease in insulin response in the AEX+WL group was
significantly greater than that in the other three groups. The glucose area
decreased significantly in the WL and AEX+WL groups but did not change in
the Con or AEX groups. There were significant increases in insulin-mediated
glucose disposal rates as measured by the hyperinsulinemic (600
pmol.m-2.min-1) euglycemic clamps in the AEX and AEX+WL groups [1.66 +/-
0.50 and 1.76 +/- 0.41 mg.kg fat-free mass (FFM)-1.min-1, respectively]
that were significantly greater than those in the WL (0.13 +/- 0.31 mg.kg
FFM-1.min-1) and Con groups (-0.05 +/- 0.51 mg.kg FFM-1.min-1; n = 5).
These data suggest that AEX and WL improve glucose metabolism through
different mechanisms and that the combined intervention of AEX+WL is
necessary to improve both glucose tolerance and insulin sensitivity in
older men.</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>8828680</pmid><doi>10.1152/jappl.1996.81.1.318</doi><tpages>8</tpages></addata></record> |
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source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals |
subjects | Anaerobic Threshold - physiology Biological and medical sciences Blood Glucose - metabolism Body Composition - physiology Diet, Reducing Exercise - physiology Glucose - metabolism Glucose Clamp Technique Glucose Tolerance Test Homeostasis - physiology Humans Insulin Resistance - physiology Male Medical sciences Metabolic diseases Middle Aged Obesity Obesity - metabolism Obesity - physiopathology Oxygen Consumption - physiology Physical Fitness Weight Loss - physiology |
title | Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men |
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