Immunological Effects Following Administration of Interferon-α in Patients with Chronic Hepatitis C Virus (cHCV) Infection
Abstract The immunological effects of interferon (IFN)-α administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-α three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided int...
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| Veröffentlicht in: | Immunopharmacology and immunotoxicology 1996-01, Vol.18 (3), p.355-374 |
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| container_title | Immunopharmacology and immunotoxicology |
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| creator | Jlrlllo, Emlllo Greco, Beatrice Caradonna, Lulgl Satalino, Rosa Amati, Lulgl Cozzolongo, Raffaele Cuppone, Renato Manghisi, Onofrio G. |
| description | Abstract
The immunological effects of interferon (IFN)-α administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-α three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 subjects) and nonresponders (3 subjects) respectively according to alanine aminotransferase serum levels at the end of treatment. Before therapy (To) absolute numbers of CD3+ CD4+ CD8+ CD14+ and CD16+ cells were significantly reduced in both groups when compared to normal values. At the same time all patients displayed a profound decrease of phagocytosis and killing exerted by both polymorphonuclear cells (PMN) and monocytes (MO). However MO Killing resulted to be normal in the responder group. With special reference to T cell function T cell mediated antibacterial activity using Salmonella typhi as a target was also significantly reduced. After therapy (T12) in responder patients a significant increase of CD3+ CD4+ CD14+ and CD16+ cell absolute numbers was observed while phagocytic and T cell functions were still depressed.
Among the nonresponders in two of three patients IFN-α administration gave rise to an increase (above normality) of CD3+ CD4+ CD8+ CD14+ CD16+ and CD20+ cell absolute numbers while in one patient the same markers dramatically dropped below normal range. In two patients antibacterial activity was significantly augmented by IFN-α treatment whereas in one patient no modification was observed. Finally in the same patients IFN-α did not correct PMN and MO pretreatment deficits. |
| doi_str_mv | 10.3109/08923979609052741 |
| format | Article |
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The immunological effects of interferon (IFN)-α administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-α three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 subjects) and nonresponders (3 subjects) respectively according to alanine aminotransferase serum levels at the end of treatment. Before therapy (To) absolute numbers of CD3+ CD4+ CD8+ CD14+ and CD16+ cells were significantly reduced in both groups when compared to normal values. At the same time all patients displayed a profound decrease of phagocytosis and killing exerted by both polymorphonuclear cells (PMN) and monocytes (MO). However MO Killing resulted to be normal in the responder group. With special reference to T cell function T cell mediated antibacterial activity using Salmonella typhi as a target was also significantly reduced. After therapy (T12) in responder patients a significant increase of CD3+ CD4+ CD14+ and CD16+ cell absolute numbers was observed while phagocytic and T cell functions were still depressed.
Among the nonresponders in two of three patients IFN-α administration gave rise to an increase (above normality) of CD3+ CD4+ CD8+ CD14+ CD16+ and CD20+ cell absolute numbers while in one patient the same markers dramatically dropped below normal range. In two patients antibacterial activity was significantly augmented by IFN-α treatment whereas in one patient no modification was observed. Finally in the same patients IFN-α did not correct PMN and MO pretreatment deficits.</description><identifier>ISSN: 0892-3973</identifier><identifier>EISSN: 1532-2513</identifier><identifier>DOI: 10.3109/08923979609052741</identifier><identifier>PMID: 8872490</identifier><identifier>CODEN: IITOEF</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Female ; Hepacivirus - drug effects ; Hepatitis C - immunology ; Hepatitis C - therapy ; hepatitis C virus ; Hepatitis, Chronic - immunology ; Hepatitis, Chronic - therapy ; Humans ; Immunization, Passive ; Immunomodulators ; Interferon-alpha - immunology ; Interferon-alpha - therapeutic use ; Leukocytes, Mononuclear - drug effects ; Macrophages - drug effects ; Male ; Medical sciences ; Middle Aged ; Neutrophils - drug effects ; Phagocytosis - drug effects ; Pharmacology. Drug treatments</subject><ispartof>Immunopharmacology and immunotoxicology, 1996-01, Vol.18 (3), p.355-374</ispartof><rights>1996 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-546770bb2f6b5d51540f273f39121f46aea316d3a1a307b57257a8577a457abc3</citedby><cites>FETCH-LOGICAL-c461t-546770bb2f6b5d51540f273f39121f46aea316d3a1a307b57257a8577a457abc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08923979609052741$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08923979609052741$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3193786$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8872490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jlrlllo, Emlllo</creatorcontrib><creatorcontrib>Greco, Beatrice</creatorcontrib><creatorcontrib>Caradonna, Lulgl</creatorcontrib><creatorcontrib>Satalino, Rosa</creatorcontrib><creatorcontrib>Amati, Lulgl</creatorcontrib><creatorcontrib>Cozzolongo, Raffaele</creatorcontrib><creatorcontrib>Cuppone, Renato</creatorcontrib><creatorcontrib>Manghisi, Onofrio G.</creatorcontrib><title>Immunological Effects Following Administration of Interferon-α in Patients with Chronic Hepatitis C Virus (cHCV) Infection</title><title>Immunopharmacology and immunotoxicology</title><addtitle>Immunopharmacol Immunotoxicol</addtitle><description>Abstract
The immunological effects of interferon (IFN)-α administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-α three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 subjects) and nonresponders (3 subjects) respectively according to alanine aminotransferase serum levels at the end of treatment. Before therapy (To) absolute numbers of CD3+ CD4+ CD8+ CD14+ and CD16+ cells were significantly reduced in both groups when compared to normal values. At the same time all patients displayed a profound decrease of phagocytosis and killing exerted by both polymorphonuclear cells (PMN) and monocytes (MO). However MO Killing resulted to be normal in the responder group. With special reference to T cell function T cell mediated antibacterial activity using Salmonella typhi as a target was also significantly reduced. After therapy (T12) in responder patients a significant increase of CD3+ CD4+ CD14+ and CD16+ cell absolute numbers was observed while phagocytic and T cell functions were still depressed.
Among the nonresponders in two of three patients IFN-α administration gave rise to an increase (above normality) of CD3+ CD4+ CD8+ CD14+ CD16+ and CD20+ cell absolute numbers while in one patient the same markers dramatically dropped below normal range. In two patients antibacterial activity was significantly augmented by IFN-α treatment whereas in one patient no modification was observed. Finally in the same patients IFN-α did not correct PMN and MO pretreatment deficits.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Hepacivirus - drug effects</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - therapy</subject><subject>hepatitis C virus</subject><subject>Hepatitis, Chronic - immunology</subject><subject>Hepatitis, Chronic - therapy</subject><subject>Humans</subject><subject>Immunization, Passive</subject><subject>Immunomodulators</subject><subject>Interferon-alpha - immunology</subject><subject>Interferon-alpha - therapeutic use</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Macrophages - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophils - drug effects</subject><subject>Phagocytosis - drug effects</subject><subject>Pharmacology. Drug treatments</subject><issn>0892-3973</issn><issn>1532-2513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9rFDEchoNY6lr9AB6EHET0MJo_k8mEeilD6y4U9KC9DplM0k3JJGuSYSl-Kr9IP1Oz7LYgQj0l5H2eXxJeAN5g9IliJD6jVhAquGiQQIzwGj8DC8woqQjD9DlY7PKqAPQFeJnSDUJYcMSOwXHbclILtAC_V9M0--DCtVXSwXNjtMoJXgTnwtb6a3g2TtbblKPMNngYDFz5rKPRMfjq7g-0Hn4vkfbF2tq8ht26JFbBpd6U82wT7OCVjXOCH9Syu_pY_N0dZdgrcGSkS_r1YT0BPy_Of3TL6vLb11V3dlmpusG5YnXDORoGYpqBjQyzGhnCqaECE2zqRmpJcTNSiSVFfGCcMC5bxrmsy2ZQ9AS838_dxPBr1in3k01KOye9DnPqeVvXqKHtf0HMuBAIsQLiPahiSClq02-inWS87THqd830_zRTnLeH4fMw6fHROFRR8neHXKZShYnSK5seMYoF5W1TsC97zHoT4iS3Ibqxz_LWhfjg0KdecfqXvtbS5bWSUfc3YY6-9PDEH-4BQXy7aQ</recordid><startdate>19960101</startdate><enddate>19960101</enddate><creator>Jlrlllo, Emlllo</creator><creator>Greco, Beatrice</creator><creator>Caradonna, Lulgl</creator><creator>Satalino, Rosa</creator><creator>Amati, Lulgl</creator><creator>Cozzolongo, Raffaele</creator><creator>Cuppone, Renato</creator><creator>Manghisi, Onofrio G.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19960101</creationdate><title>Immunological Effects Following Administration of Interferon-α in Patients with Chronic Hepatitis C Virus (cHCV) Infection</title><author>Jlrlllo, Emlllo ; Greco, Beatrice ; Caradonna, Lulgl ; Satalino, Rosa ; Amati, Lulgl ; Cozzolongo, Raffaele ; Cuppone, Renato ; Manghisi, Onofrio G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-546770bb2f6b5d51540f273f39121f46aea316d3a1a307b57257a8577a457abc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Hepacivirus - drug effects</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C - therapy</topic><topic>hepatitis C virus</topic><topic>Hepatitis, Chronic - immunology</topic><topic>Hepatitis, Chronic - therapy</topic><topic>Humans</topic><topic>Immunization, Passive</topic><topic>Immunomodulators</topic><topic>Interferon-alpha - immunology</topic><topic>Interferon-alpha - therapeutic use</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Macrophages - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutrophils - drug effects</topic><topic>Phagocytosis - drug effects</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jlrlllo, Emlllo</creatorcontrib><creatorcontrib>Greco, Beatrice</creatorcontrib><creatorcontrib>Caradonna, Lulgl</creatorcontrib><creatorcontrib>Satalino, Rosa</creatorcontrib><creatorcontrib>Amati, Lulgl</creatorcontrib><creatorcontrib>Cozzolongo, Raffaele</creatorcontrib><creatorcontrib>Cuppone, Renato</creatorcontrib><creatorcontrib>Manghisi, Onofrio G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunopharmacology and immunotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jlrlllo, Emlllo</au><au>Greco, Beatrice</au><au>Caradonna, Lulgl</au><au>Satalino, Rosa</au><au>Amati, Lulgl</au><au>Cozzolongo, Raffaele</au><au>Cuppone, Renato</au><au>Manghisi, Onofrio G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunological Effects Following Administration of Interferon-α in Patients with Chronic Hepatitis C Virus (cHCV) Infection</atitle><jtitle>Immunopharmacology and immunotoxicology</jtitle><addtitle>Immunopharmacol Immunotoxicol</addtitle><date>1996-01-01</date><risdate>1996</risdate><volume>18</volume><issue>3</issue><spage>355</spage><epage>374</epage><pages>355-374</pages><issn>0892-3973</issn><eissn>1532-2513</eissn><coden>IITOEF</coden><abstract>Abstract
The immunological effects of interferon (IFN)-α administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-α three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 subjects) and nonresponders (3 subjects) respectively according to alanine aminotransferase serum levels at the end of treatment. Before therapy (To) absolute numbers of CD3+ CD4+ CD8+ CD14+ and CD16+ cells were significantly reduced in both groups when compared to normal values. At the same time all patients displayed a profound decrease of phagocytosis and killing exerted by both polymorphonuclear cells (PMN) and monocytes (MO). However MO Killing resulted to be normal in the responder group. With special reference to T cell function T cell mediated antibacterial activity using Salmonella typhi as a target was also significantly reduced. After therapy (T12) in responder patients a significant increase of CD3+ CD4+ CD14+ and CD16+ cell absolute numbers was observed while phagocytic and T cell functions were still depressed.
Among the nonresponders in two of three patients IFN-α administration gave rise to an increase (above normality) of CD3+ CD4+ CD8+ CD14+ CD16+ and CD20+ cell absolute numbers while in one patient the same markers dramatically dropped below normal range. In two patients antibacterial activity was significantly augmented by IFN-α treatment whereas in one patient no modification was observed. Finally in the same patients IFN-α did not correct PMN and MO pretreatment deficits.</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>8872490</pmid><doi>10.3109/08923979609052741</doi><tpages>20</tpages></addata></record> |
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| identifier | ISSN: 0892-3973 |
| ispartof | Immunopharmacology and immunotoxicology, 1996-01, Vol.18 (3), p.355-374 |
| issn | 0892-3973 1532-2513 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_3193786 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Aged Biological and medical sciences Female Hepacivirus - drug effects Hepatitis C - immunology Hepatitis C - therapy hepatitis C virus Hepatitis, Chronic - immunology Hepatitis, Chronic - therapy Humans Immunization, Passive Immunomodulators Interferon-alpha - immunology Interferon-alpha - therapeutic use Leukocytes, Mononuclear - drug effects Macrophages - drug effects Male Medical sciences Middle Aged Neutrophils - drug effects Phagocytosis - drug effects Pharmacology. Drug treatments |
| title | Immunological Effects Following Administration of Interferon-α in Patients with Chronic Hepatitis C Virus (cHCV) Infection |
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