Increased Matrix Proteins, Collagen and Transforming Growth Factor are Early Markers of Hepatotoxicity in Patients on Long-Term Methotrexate Therapy

Background: Hepatotoxicity, which may lead to fibrosis and cirrhosis, often limits the use of long-term low dose methotrexate for psoriasis and autoimmune diseases. Standard light microscopy lacks sensitivity for early fibrosis. Design: This is a retrospective study of immunohistochemical markers of...

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Veröffentlicht in:	Clinical toxicology (Philadelphia, Pa.) Pa.), 1996, Vol.34 (3), p.301-305
Hauptverfasser:	Jaskiewicz, K., Voigt, H., Blakolmer, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Biomarkers - analysis Biopsy Collagen - analysis Drug toxicity and drugs side effects treatment Extracellular Matrix Proteins - analysis Female Humans Immunohistochemistry Immunosuppressive Agents - adverse effects Liver - chemistry Liver - drug effects Liver - pathology Liver Cirrhosis - chemically induced Liver Cirrhosis - diagnosis Male Medical sciences Methotrexate - adverse effects Middle Aged Pharmacology. Drug treatments Retrospective Studies Toxicity: digestive system Transforming Growth Factors - analysis
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