ERCC1/ERCC4 5-endonuclease activity as a determinant of hypoxic cell radiosensitivity

In this study, the relationships between cellular oxygen enhancement ratios (OER) and nucleotide excision repair capability were examined using the UV20 mutant cell line (which has a defective ERCC1 gene). Using a clonogenic survival assay, the OER for the killing of wild-type AA8 cells was 3.2 +/-...

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Veröffentlicht in:	International journal of radiation biology 1996, Vol.69 (3), p.319-327
1. Verfasser:	MURRAY, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological effects of radiation Cell Hypoxia - genetics Cell Hypoxia - physiology Cell Hypoxia - radiation effects Cell Survival - radiation effects CHO Cells Colony-Forming Units Assay Cricetinae DNA Damage DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dose-Response Relationship, Radiation Endonucleases - genetics Endonucleases - metabolism Fundamental and applied biological sciences. Psychology Humans Ionizing radiations Mutation Oxygen - metabolism Proteins - genetics Proteins - metabolism Radiation Tolerance - genetics Radiation Tolerance - physiology Tissues, organs and organisms biophysics Transfection
Online-Zugang:	Volltext
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