Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives:  Potent and Selective A2A Adenosine Antagonists

A series of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives (10a−o,q,r), bearing alkyl and aralkyl chains on positions 7 and 8, were synthesized in the attempt to obtain potent and selective antagonists for the A2A adenosine receptor subtype. The compounds were tested in binding and func...

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Veröffentlicht in:	Journal of medicinal chemistry 1996-03, Vol.39 (5), p.1164-1171
Hauptverfasser:	Baraldi, Pier Giovanni, Cacciari, Barbara, Spalluto, Giampiero, Pineda de las Infantas y Villatoro, Maria José, Zocchi, Cristina, Dionisotti, Silvio, Ongini, Ennio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments
Online-Zugang:	Volltext
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