Structure-activity studies of analogs of β, γ-methylene-ATP at P2X-purinoceptors in the rabbit ear central artery

Structure‐activity studies using naphthylmethyl analogs of β, γ‐methylene‐ATP were conducted at the P2X‐purinoceptor that mediates contraction of the rabbit ear central artery by ATP, α, β‐m‐ATP. On the adenine base, substitution at the C2‐position (WRC‐0440) increased the agonist potency 2‐fold and...

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Veröffentlicht in:	Drug development research 1995-12, Vol.36 (4), p.153-165
Hauptverfasser:	Martin, Pauline L., Gero, Thomas W., Potts, Alice Anne, Cusack, Noel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP analogs Biological and medical sciences L-AMP-PCP Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors P2X-purinoceptors Pharmacology. Drug treatments rabbit ear artery vascular smooth muscle α,β‐methylene‐ATP β,γ‐methylene‐ATP β-methylene-ATP γ-methylene-ATP
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