Evaluation of Urinary Mercury Excretion After Administration of 2,3-Dimercapto-1-propane Sulfonic Acid to Occupationally Exposed Men
Abstract The purpose of this study was to determine the clinical efficacy of 2,3-dimercapto-l-propane sulfonic acid, Na salt, on the urinary excretion of mercury as well as its possible adverse effects. Ten men with occupational mercury exposure (urinary level of 50 pg/g creatinine or more) were ass...
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| Veröffentlicht in: | Clinical toxicology (Philadelphia, Pa.) Pa.), 1995, Vol.33 (6), p.717-720 |
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| container_title | Clinical toxicology (Philadelphia, Pa.) |
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| creator | Torres-Alanís, Oscar Garza-Ocañas, Lourdes Pineyro-Lopez, Alfredo |
| description | Abstract
The purpose of this study was to determine the clinical efficacy of 2,3-dimercapto-l-propane sulfonic acid, Na salt, on the urinary excretion of mercury as well as its possible adverse effects. Ten men with occupational mercury exposure (urinary level of 50 pg/g creatinine or more) were assigned to receive 2,3-dimercapto-l-propane sulfonic acid p.o. (DIMAVAL capsules, 100 mg) 300 mg/d for five days. Informed written consent was obtained from each subject. Hematology analyses, blood, chemistry, and urinalysis were obtained at the start of the study, at the end of the 2,3-dimercapto-l-propane sulfonic acid treatment and 72 hours after the administration of the final dose of 2,3-dimercapto-l-propane sulfonic acid. Twenty-four-hour urine mercury levels were closely monitored throughout therapy. All data and measurements before and during drug doses were evaluated by analyses of variance. In all subjects mean urine mercury was significantly increased (p |
| doi_str_mv | 10.3109/15563659509010636 |
| format | Article |
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The purpose of this study was to determine the clinical efficacy of 2,3-dimercapto-l-propane sulfonic acid, Na salt, on the urinary excretion of mercury as well as its possible adverse effects. Ten men with occupational mercury exposure (urinary level of 50 pg/g creatinine or more) were assigned to receive 2,3-dimercapto-l-propane sulfonic acid p.o. (DIMAVAL capsules, 100 mg) 300 mg/d for five days. Informed written consent was obtained from each subject. Hematology analyses, blood, chemistry, and urinalysis were obtained at the start of the study, at the end of the 2,3-dimercapto-l-propane sulfonic acid treatment and 72 hours after the administration of the final dose of 2,3-dimercapto-l-propane sulfonic acid. Twenty-four-hour urine mercury levels were closely monitored throughout therapy. All data and measurements before and during drug doses were evaluated by analyses of variance. In all subjects mean urine mercury was significantly increased (p <. 05) after pre-2,3-dimercapto-l-propane sulfonic acid treatment. One subject had a moderate hypersensitivity reaction (rash) to 2,3-dimercapto-l-propane sulfonic acid but no other toxic effects were observed.</description><identifier>ISSN: 1556-3650</identifier><identifier>ISSN: 0731-3810</identifier><identifier>EISSN: 1556-9519</identifier><identifier>EISSN: 1097-9875</identifier><identifier>DOI: 10.3109/15563659509010636</identifier><identifier>PMID: 8523500</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>2,3-dimercapto-l-propane ; Adult ; Biological and medical sciences ; Chelating Agents - therapeutic use ; Chelation Therapy ; Chemical and industrial products toxicology. Toxic occupational diseases ; Creatinine - urine ; Dimaval ; DMPS ; Humans ; Male ; Medical sciences ; mercury ; Mercury - urine ; Mercury Poisoning - drug therapy ; Mercury Poisoning - urine ; Metals and various inorganic compounds ; Middle Aged ; Occupational Diseases - chemically induced ; Occupational Diseases - urine ; Prospective Studies ; Toxicology ; Unithiol - adverse effects ; Unithiol - therapeutic use</subject><ispartof>Clinical toxicology (Philadelphia, Pa.), 1995, Vol.33 (6), p.717-720</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-d2ac63690bea4569d97cddbb7dc9cab8610b19962966cbce3f04263e60a82c2c3</citedby><cites>FETCH-LOGICAL-c496t-d2ac63690bea4569d97cddbb7dc9cab8610b19962966cbce3f04263e60a82c2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/15563659509010636$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/15563659509010636$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,4024,4050,4051,23930,23931,25140,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2937885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8523500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torres-Alanís, Oscar</creatorcontrib><creatorcontrib>Garza-Ocañas, Lourdes</creatorcontrib><creatorcontrib>Pineyro-Lopez, Alfredo</creatorcontrib><title>Evaluation of Urinary Mercury Excretion After Administration of 2,3-Dimercapto-1-propane Sulfonic Acid to Occupationally Exposed Men</title><title>Clinical toxicology (Philadelphia, Pa.)</title><addtitle>J Toxicol Clin Toxicol</addtitle><description>Abstract
The purpose of this study was to determine the clinical efficacy of 2,3-dimercapto-l-propane sulfonic acid, Na salt, on the urinary excretion of mercury as well as its possible adverse effects. Ten men with occupational mercury exposure (urinary level of 50 pg/g creatinine or more) were assigned to receive 2,3-dimercapto-l-propane sulfonic acid p.o. (DIMAVAL capsules, 100 mg) 300 mg/d for five days. Informed written consent was obtained from each subject. Hematology analyses, blood, chemistry, and urinalysis were obtained at the start of the study, at the end of the 2,3-dimercapto-l-propane sulfonic acid treatment and 72 hours after the administration of the final dose of 2,3-dimercapto-l-propane sulfonic acid. Twenty-four-hour urine mercury levels were closely monitored throughout therapy. All data and measurements before and during drug doses were evaluated by analyses of variance. In all subjects mean urine mercury was significantly increased (p <. 05) after pre-2,3-dimercapto-l-propane sulfonic acid treatment. One subject had a moderate hypersensitivity reaction (rash) to 2,3-dimercapto-l-propane sulfonic acid but no other toxic effects were observed.</description><subject>2,3-dimercapto-l-propane</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chelating Agents - therapeutic use</subject><subject>Chelation Therapy</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Creatinine - urine</subject><subject>Dimaval</subject><subject>DMPS</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>mercury</subject><subject>Mercury - urine</subject><subject>Mercury Poisoning - drug therapy</subject><subject>Mercury Poisoning - urine</subject><subject>Metals and various inorganic compounds</subject><subject>Middle Aged</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Diseases - urine</subject><subject>Prospective Studies</subject><subject>Toxicology</subject><subject>Unithiol - adverse effects</subject><subject>Unithiol - therapeutic use</subject><issn>1556-3650</issn><issn>0731-3810</issn><issn>1556-9519</issn><issn>1097-9875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9P3DAQxa2qaKHQD8ABKYcem2LHa28suKzotiCBONA9R5OxI4ycOLITYO_94PX-6UoIidOM_N5vxvMIOWX0B2dUnTMhJJdCCaooo6n9RI7Wb7kSTH3e9clAD8mXGJ8o5eVUsQmZlKLggtIj8nfxDG6Ewfou8022DLaDsMruTMAx1cUrBrMR581gQjbXre1sHMKeKL7z_Kdtkx_6wecs74PvoTPZw-ga31nM5mh1NvjsHnHsNxw4tx7d-2h0WtWdkIMGXDRfd_WYLH8t_lxd57f3v2-u5rc5TpUccl0AphsVrQ1MhVRazVDrup5pVAh1KRmtmVKyUFJijYY3dFpIbiSFssAC-TFh27kYfIzBNFUfbJvurRit1oFW7wJNzNmW6ce6NXpP7BJM-redDhHBNQE6tHFvKxSflaVItsutzXaNDy28-OB0NcDK-fCf4R_94uIN_mjADY8IwVRPfgwp0fjBDf8AS3Kkjg</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Torres-Alanís, Oscar</creator><creator>Garza-Ocañas, Lourdes</creator><creator>Pineyro-Lopez, Alfredo</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1995</creationdate><title>Evaluation of Urinary Mercury Excretion After Administration of 2,3-Dimercapto-1-propane Sulfonic Acid to Occupationally Exposed Men</title><author>Torres-Alanís, Oscar ; Garza-Ocañas, Lourdes ; Pineyro-Lopez, Alfredo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-d2ac63690bea4569d97cddbb7dc9cab8610b19962966cbce3f04263e60a82c2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>2,3-dimercapto-l-propane</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chelating Agents - therapeutic use</topic><topic>Chelation Therapy</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Creatinine - urine</topic><topic>Dimaval</topic><topic>DMPS</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>mercury</topic><topic>Mercury - urine</topic><topic>Mercury Poisoning - drug therapy</topic><topic>Mercury Poisoning - urine</topic><topic>Metals and various inorganic compounds</topic><topic>Middle Aged</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Diseases - urine</topic><topic>Prospective Studies</topic><topic>Toxicology</topic><topic>Unithiol - adverse effects</topic><topic>Unithiol - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torres-Alanís, Oscar</creatorcontrib><creatorcontrib>Garza-Ocañas, Lourdes</creatorcontrib><creatorcontrib>Pineyro-Lopez, Alfredo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torres-Alanís, Oscar</au><au>Garza-Ocañas, Lourdes</au><au>Pineyro-Lopez, Alfredo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Urinary Mercury Excretion After Administration of 2,3-Dimercapto-1-propane Sulfonic Acid to Occupationally Exposed Men</atitle><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle><addtitle>J Toxicol Clin Toxicol</addtitle><date>1995</date><risdate>1995</risdate><volume>33</volume><issue>6</issue><spage>717</spage><epage>720</epage><pages>717-720</pages><issn>1556-3650</issn><issn>0731-3810</issn><eissn>1556-9519</eissn><eissn>1097-9875</eissn><abstract>Abstract
The purpose of this study was to determine the clinical efficacy of 2,3-dimercapto-l-propane sulfonic acid, Na salt, on the urinary excretion of mercury as well as its possible adverse effects. Ten men with occupational mercury exposure (urinary level of 50 pg/g creatinine or more) were assigned to receive 2,3-dimercapto-l-propane sulfonic acid p.o. (DIMAVAL capsules, 100 mg) 300 mg/d for five days. Informed written consent was obtained from each subject. Hematology analyses, blood, chemistry, and urinalysis were obtained at the start of the study, at the end of the 2,3-dimercapto-l-propane sulfonic acid treatment and 72 hours after the administration of the final dose of 2,3-dimercapto-l-propane sulfonic acid. Twenty-four-hour urine mercury levels were closely monitored throughout therapy. All data and measurements before and during drug doses were evaluated by analyses of variance. In all subjects mean urine mercury was significantly increased (p <. 05) after pre-2,3-dimercapto-l-propane sulfonic acid treatment. One subject had a moderate hypersensitivity reaction (rash) to 2,3-dimercapto-l-propane sulfonic acid but no other toxic effects were observed.</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>8523500</pmid><doi>10.3109/15563659509010636</doi><tpages>4</tpages></addata></record> |
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| ispartof | Clinical toxicology (Philadelphia, Pa.), 1995, Vol.33 (6), p.717-720 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | 2,3-dimercapto-l-propane Adult Biological and medical sciences Chelating Agents - therapeutic use Chelation Therapy Chemical and industrial products toxicology. Toxic occupational diseases Creatinine - urine Dimaval DMPS Humans Male Medical sciences mercury Mercury - urine Mercury Poisoning - drug therapy Mercury Poisoning - urine Metals and various inorganic compounds Middle Aged Occupational Diseases - chemically induced Occupational Diseases - urine Prospective Studies Toxicology Unithiol - adverse effects Unithiol - therapeutic use |
| title | Evaluation of Urinary Mercury Excretion After Administration of 2,3-Dimercapto-1-propane Sulfonic Acid to Occupationally Exposed Men |
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