Synthesis and Pharmacological Characterization of 3-[2-((3aR,9bR)-cis-6-Methoxy- 2,3,3a,4,5,9b-hexahydro-1H- benz[e]isoindol-2-yl)ethyl]pyrido[3‘,4‘:4,5]thieno[3,2-d]pyrimidine- 2,4(1H,3H)-dione (A-131701):  A Uroselective α1A Adrenoceptor Antagonist for the Symptomatic Treatment of Benign Prostatic Hyperplasia

Synthesis and Pharmacological Characterization of 3-[2-((3aR,9bR)-cis-6-Methoxy- 2,3,3a,4,5,9b-hexahydro-1H- benz[e]isoindol-2-yl)ethyl]pyrido[3‘,4‘:4,5]thieno[3,2-d]pyrimidine- 2,4(1H,3H)-dione (A-131701):  A Uroselective α1A Adrenoceptor Antagonist for the Symptomatic Treatment of Benign Prostatic Hyperplasia

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Veröffentlicht in:Journal of medicinal chemistry 1997-09, Vol.40 (20), p.3141-3143
Hauptverfasser: Meyer, Michael D, Altenbach, Robert J, Basha, Fatima Z, Carroll, William A, Drizin, Irene, Elmore, Steven W, Ehrlich, Paul P, Lebold, Suzanne A, Tietje, Karin, Sippy, Kevin B, Wendt, Michael D, Plata, Daniel J, Plagge, Fred, Buckner, Steven A, Brune, Michael E, Hancock, Arthur A, Kerwin, James F
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Pharmacology. Drug treatments
Urinary system
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container_end_page 3143
container_issue 20
container_start_page 3141
container_title Journal of medicinal chemistry
container_volume 40
creator Meyer, Michael D
Altenbach, Robert J
Basha, Fatima Z
Carroll, William A
Drizin, Irene
Elmore, Steven W
Ehrlich, Paul P
Lebold, Suzanne A
Tietje, Karin
Sippy, Kevin B
Wendt, Michael D
Plata, Daniel J
Plagge, Fred
Buckner, Steven A
Brune, Michael E
Hancock, Arthur A
Kerwin, James F
description
doi_str_mv 10.1021/jm970364a
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subjects Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Urinary system
title Synthesis and Pharmacological Characterization of 3-[2-((3aR,9bR)-cis-6-Methoxy- 2,3,3a,4,5,9b-hexahydro-1H- benz[e]isoindol-2-yl)ethyl]pyrido[3‘,4‘:4,5]thieno[3,2-d]pyrimidine- 2,4(1H,3H)-dione (A-131701):  A Uroselective α1A Adrenoceptor Antagonist for the Symptomatic Treatment of Benign Prostatic Hyperplasia
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