Latent Variable Models for Teratogenesis Using Multiple Binary Outcomes
Multiple outcomes are commonly measured in the study of birth defects. The reason is that most teratogens do not cause a single, uniquely defined defect, but rather result in a range of effects, including major malformations, minor anomalies, and deficiencies in birth weight, length and head circumf...
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Veröffentlicht in: | Journal of the American Statistical Association 1997-03, Vol.92 (437), p.13-20 |
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description | Multiple outcomes are commonly measured in the study of birth defects. The reason is that most teratogens do not cause a single, uniquely defined defect, but rather result in a range of effects, including major malformations, minor anomalies, and deficiencies in birth weight, length and head circumference. The spectrum of effects associated with a particular teratogen is sometimes described as a "syndrome." In this article we develop a latent variable model to characterize exposure effects on multiple binary outcomes. Not only does the method allow comparisons of control and exposed infants with respect to multiple outcomes, but it also provides a measure of the "severity" of each child's condition. Data from a study of the teratogenic effects of anticonvulsants illustrate our results. |
doi_str_mv | 10.1080/01621459.1997.10473598 |
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The reason is that most teratogens do not cause a single, uniquely defined defect, but rather result in a range of effects, including major malformations, minor anomalies, and deficiencies in birth weight, length and head circumference. The spectrum of effects associated with a particular teratogen is sometimes described as a "syndrome." In this article we develop a latent variable model to characterize exposure effects on multiple binary outcomes. Not only does the method allow comparisons of control and exposed infants with respect to multiple outcomes, but it also provides a measure of the "severity" of each child's condition. Data from a study of the teratogenic effects of anticonvulsants illustrate our results.</description><identifier>ISSN: 0162-1459</identifier><identifier>EISSN: 1537-274X</identifier><identifier>DOI: 10.1080/01621459.1997.10473598</identifier><identifier>CODEN: JSTNAL</identifier><language>eng</language><publisher>Alexandria, VA: Taylor & Francis Group</publisher><subject>Anticonvulsants ; Applications ; Applications and Case Studies ; Binary system ; Biology, psychology, social sciences ; Birth ; Birth defects ; Birth weight ; Children ; Exact sciences and technology ; Infants ; Insurance, economics, finance ; Item response theory ; Logistic regression ; Logistics ; Mathematics ; Medical sciences ; Modeling ; Multivariate analysis ; Neonatal disorders ; Newborn babies ; Probability and statistics ; Random effects ; Rasch model ; Regression analysis ; Reliability, life testing, quality control ; Sciences and techniques of general use ; Statistical analysis ; Statistical methods ; Statistics ; Teratogenesis ; Teratology</subject><ispartof>Journal of the American Statistical Association, 1997-03, Vol.92 (437), p.13-20</ispartof><rights>Copyright Taylor & Francis Group, LLC 1997</rights><rights>Copyright 1997 American Statistical Association</rights><rights>1997 INIST-CNRS</rights><rights>Copyright American Statistical Association Mar 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-b3938158bf883a67cb721799aa37c476398ab619d71860f5d8c0f84fda4becc93</citedby><cites>FETCH-LOGICAL-c371t-b3938158bf883a67cb721799aa37c476398ab619d71860f5d8c0f84fda4becc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2291445$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2291445$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,832,27869,27924,27925,58017,58021,58250,58254,59647,60436</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2791087$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Legler, Julie M.</creatorcontrib><creatorcontrib>Ryan, Louise M.</creatorcontrib><creatorcontrib>Ryan, Louise M.</creatorcontrib><title>Latent Variable Models for Teratogenesis Using Multiple Binary Outcomes</title><title>Journal of the American Statistical Association</title><description>Multiple outcomes are commonly measured in the study of birth defects. The reason is that most teratogens do not cause a single, uniquely defined defect, but rather result in a range of effects, including major malformations, minor anomalies, and deficiencies in birth weight, length and head circumference. The spectrum of effects associated with a particular teratogen is sometimes described as a "syndrome." In this article we develop a latent variable model to characterize exposure effects on multiple binary outcomes. Not only does the method allow comparisons of control and exposed infants with respect to multiple outcomes, but it also provides a measure of the "severity" of each child's condition. Data from a study of the teratogenic effects of anticonvulsants illustrate our results.</description><subject>Anticonvulsants</subject><subject>Applications</subject><subject>Applications and Case Studies</subject><subject>Binary system</subject><subject>Biology, psychology, social sciences</subject><subject>Birth</subject><subject>Birth defects</subject><subject>Birth weight</subject><subject>Children</subject><subject>Exact sciences and technology</subject><subject>Infants</subject><subject>Insurance, economics, finance</subject><subject>Item response theory</subject><subject>Logistic regression</subject><subject>Logistics</subject><subject>Mathematics</subject><subject>Medical sciences</subject><subject>Modeling</subject><subject>Multivariate analysis</subject><subject>Neonatal disorders</subject><subject>Newborn babies</subject><subject>Probability and statistics</subject><subject>Random effects</subject><subject>Rasch model</subject><subject>Regression analysis</subject><subject>Reliability, life testing, quality control</subject><subject>Sciences and techniques of general use</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Statistics</subject><subject>Teratogenesis</subject><subject>Teratology</subject><issn>0162-1459</issn><issn>1537-274X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>K30</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV9LHDEUxYO04HbrVyiDFvo0mn8zSR6ttLaw4otK38KdTEayZCdrkkH89s2wrhahmJcL4XfOPclB6AvBpwRLfIZJSwlv1ClRSpQrLlij5AFakIaJmgr-5wNazFA9U4foU0prXI6QcoEuV5DtmKs7iA46b6ur0FufqiHE6sZGyOHejja5VN0mN95XV5PPblu4726E-FRdT9mEjU2f0ccBfLJHz3OJbn_-uLn4Va-uL39fnK9qwwTJdccUk6SR3SAlg1aYTlAilAJgwnDRMiWha4nqBZEtHppeGjxIPvTAO2uMYkv0bee7jeFhsinrjUvGeg-jDVPSkiksCG1YIY_fkOswxbGE0-VPJCWyrFuik_9BhAvOWDGbqXZHmRhSinbQ2-g25fmaYD13oPcd6LkDve-gCL8-20My4IcIo3HpRU2FKmrxiq1TDvFfc1oCaEoV4bwp2PkOc2OpZwOPIfpeZ3jyIe6t2TuJ_gKk2qQa</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Legler, 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Variable Models for Teratogenesis Using Multiple Binary Outcomes</title><author>Legler, Julie M. ; Ryan, Louise M. ; Ryan, Louise M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-b3938158bf883a67cb721799aa37c476398ab619d71860f5d8c0f84fda4becc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Anticonvulsants</topic><topic>Applications</topic><topic>Applications and Case Studies</topic><topic>Binary system</topic><topic>Biology, psychology, social sciences</topic><topic>Birth</topic><topic>Birth defects</topic><topic>Birth weight</topic><topic>Children</topic><topic>Exact sciences and technology</topic><topic>Infants</topic><topic>Insurance, economics, finance</topic><topic>Item response theory</topic><topic>Logistic regression</topic><topic>Logistics</topic><topic>Mathematics</topic><topic>Medical sciences</topic><topic>Modeling</topic><topic>Multivariate analysis</topic><topic>Neonatal disorders</topic><topic>Newborn babies</topic><topic>Probability and statistics</topic><topic>Random effects</topic><topic>Rasch model</topic><topic>Regression analysis</topic><topic>Reliability, life testing, quality control</topic><topic>Sciences and techniques of general use</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Statistics</topic><topic>Teratogenesis</topic><topic>Teratology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Legler, Julie M.</creatorcontrib><creatorcontrib>Ryan, Louise M.</creatorcontrib><creatorcontrib>Ryan, Louise M.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 35</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - 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The reason is that most teratogens do not cause a single, uniquely defined defect, but rather result in a range of effects, including major malformations, minor anomalies, and deficiencies in birth weight, length and head circumference. The spectrum of effects associated with a particular teratogen is sometimes described as a "syndrome." In this article we develop a latent variable model to characterize exposure effects on multiple binary outcomes. Not only does the method allow comparisons of control and exposed infants with respect to multiple outcomes, but it also provides a measure of the "severity" of each child's condition. Data from a study of the teratogenic effects of anticonvulsants illustrate our results.</abstract><cop>Alexandria, VA</cop><pub>Taylor & Francis Group</pub><doi>10.1080/01621459.1997.10473598</doi><tpages>8</tpages></addata></record> |
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subjects | Anticonvulsants Applications Applications and Case Studies Binary system Biology, psychology, social sciences Birth Birth defects Birth weight Children Exact sciences and technology Infants Insurance, economics, finance Item response theory Logistic regression Logistics Mathematics Medical sciences Modeling Multivariate analysis Neonatal disorders Newborn babies Probability and statistics Random effects Rasch model Regression analysis Reliability, life testing, quality control Sciences and techniques of general use Statistical analysis Statistical methods Statistics Teratogenesis Teratology |
title | Latent Variable Models for Teratogenesis Using Multiple Binary Outcomes |
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