Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI

This study employed simultaneous neuroimaging with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to demonstrate the relationship between changes in receptor occupancy measured by PET and changes in brain activity inferred by fMRI. By administering the D2/D3 dopa...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-07, Vol.110 (27), p.11169-11174
Hauptverfasser:	Sander, Christin Y., Hooker, Jacob M., Catana, Ciprian, Normandin, Marc D., Alpert, Nathaniel M., Knudsen, Gitte M., Vanduffel, Wim, Rosen, Bruce R., Mandeville, Joseph B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonists Binding sites Biological and medical sciences Biological Sciences blood volume Brain Brain - blood supply Brain - drug effects Brain - metabolism Cerebellum Cerebrovascular Circulation - drug effects Dopamine Dopamine Antagonists - administration & dosage Dopamine Antagonists - pharmacokinetics Dopamine D2 Receptor Antagonists dopamine receptors Dosage Fundamental and applied biological sciences. Psychology ganglia Imaging Ligands Macaca mulatta Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Models, Neurological Neurochemistry Neurotransmitters NMR Nuclear magnetic resonance Pharmacology Positron emission tomography Positron-Emission Tomography - methods Primates Putamen Raclopride - administration & dosage Raclopride - pharmacokinetics Receptors Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - antagonists & inhibitors Receptors, Dopamine D3 - metabolism Tomography Vertebrates: nervous system and sense organs
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