Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2013-07, Vol.57 (7), p.3021-3028 |
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| container_title | Antimicrobial Agents and Chemotherapy |
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| creator | RANADE, Ranae M GILLESPIE, J. Robert SHIBATA, Sayaka VERLINDE, Christophe L. M. J FAN, Erkang HOL, Wim G. J BUCKNER, Frederick S |
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| doi_str_mv | 10.1128/AAC.02578-12 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.02578-12</identifier><identifier>PMID: 23587950</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Aminoquinolines - pharmacology ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Base Sequence ; Biological and medical sciences ; Drug Resistance - genetics ; Female ; Gene Expression Regulation, Enzymologic ; Mechanisms of Resistance ; Medical sciences ; Methionine-tRNA Ligase ; Methionine-tRNA Ligase - antagonists & inhibitors ; Methionine-tRNA Ligase - genetics ; Mice ; Parasitic Sensitivity Tests ; Pharmacology. Drug treatments ; RNA, Messenger - biosynthesis ; Sequence Analysis, DNA ; Trypanocidal Agents ; Trypanocidal Agents - pharmacology ; Trypanosoma brucei brucei ; Trypanosoma brucei brucei - drug effects ; Trypanosoma brucei brucei - enzymology ; Trypanosoma brucei brucei - metabolism ; Trypanosomiasis, African - drug therapy ; Trypanosomiasis, African - parasitology</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3021-3028</ispartof><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013, American Society for Microbiology. All Rights Reserved.</rights><rights>Copyright © 2013, American Society for Microbiology. All Rights Reserved. 2013 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a441t-3b5d30b506964e9d908c4d0358641ec018f78df3686c9b6722c68c033491fee3</citedby><cites>FETCH-LOGICAL-a441t-3b5d30b506964e9d908c4d0358641ec018f78df3686c9b6722c68c033491fee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697344/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697344/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27480326$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23587950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RANADE, Ranae M</creatorcontrib><creatorcontrib>GILLESPIE, J. Robert</creatorcontrib><creatorcontrib>SHIBATA, Sayaka</creatorcontrib><creatorcontrib>VERLINDE, Christophe L. M. J</creatorcontrib><creatorcontrib>FAN, Erkang</creatorcontrib><creatorcontrib>HOL, Wim G. J</creatorcontrib><creatorcontrib>BUCKNER, Frederick S</creatorcontrib><title>Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Aminoquinolines - pharmacology</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Drug Resistance - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Mechanisms of Resistance</subject><subject>Medical sciences</subject><subject>Methionine-tRNA Ligase</subject><subject>Methionine-tRNA Ligase - antagonists & inhibitors</subject><subject>Methionine-tRNA Ligase - genetics</subject><subject>Mice</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Sequence Analysis, DNA</subject><subject>Trypanocidal Agents</subject><subject>Trypanocidal Agents - pharmacology</subject><subject>Trypanosoma brucei brucei</subject><subject>Trypanosoma brucei brucei - drug effects</subject><subject>Trypanosoma brucei brucei - enzymology</subject><subject>Trypanosoma brucei brucei - metabolism</subject><subject>Trypanosomiasis, African - drug therapy</subject><subject>Trypanosomiasis, African - parasitology</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1vFCEYh4nR2LV682zw4MHEqXwNA5cmm_Vrk2qTunfCMO_s0OzCBtjW_e_Fbq168EQIDw8vvx9CLyk5o5Sp9_P54oywtlMNZY_QjBKtGtlq-RjNCJGyEYqIE_Qs52tS960mT9EJ463qdEtm6HYZhr2DAV9B9rnY4ACXiL9CmXwMh01Trr7N8fdDKBMUmwEvw-R7X2LK2Ae8SoedDTHHrcV9qiKPlxl_2N9JLm8gwY9dgpyrC8cRVwle2bSG8hw9Ge0mw4v79RStPn1cLb40F5efl4v5RWOFoKXhfTtw0rdEailAD5ooJwZSx5eCgiNUjZ0aRi6VdLqXHWNOKkc4F5qOAPwUnR-1u32_hcFBKMluzC75rU0HE603_54EP5l1vDFc6o4LUQXvjgKXYs4Jxoe7lJhf-Zuav7nL31BW8bdH3OYtM9dxn0L93f_YV3_P9iD-XU4F3twDNju7GVNtx-c_XFer5UxW7vWRm_x6uvUJTH3dWOtM25nOcMIo_wmHvabt</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>RANADE, Ranae M</creator><creator>GILLESPIE, J. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>23587950</pmid><doi>10.1128/AAC.02578-12</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3021-3028 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_27480326 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aminoquinolines - pharmacology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Base Sequence Biological and medical sciences Drug Resistance - genetics Female Gene Expression Regulation, Enzymologic Mechanisms of Resistance Medical sciences Methionine-tRNA Ligase Methionine-tRNA Ligase - antagonists & inhibitors Methionine-tRNA Ligase - genetics Mice Parasitic Sensitivity Tests Pharmacology. Drug treatments RNA, Messenger - biosynthesis Sequence Analysis, DNA Trypanocidal Agents Trypanocidal Agents - pharmacology Trypanosoma brucei brucei Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - enzymology Trypanosoma brucei brucei - metabolism Trypanosomiasis, African - drug therapy Trypanosomiasis, African - parasitology |
| title | Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target |
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