Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment

Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer’s disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized controlled study on elderly subjects...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-06, Vol.110 (23), p.9523-9528
Hauptverfasser:	Douaud, Gwenaëlle, Refsum, Helga, de Jager, Celeste A., Jacoby, Robin, Nichols, Thomas E., Smith, Stephen M., Smith, A. David
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer disease Alzheimer Disease - complications Alzheimer's disease Alzheimers disease atrophy Bayes Theorem Bayesian theory Biological and medical sciences Biological Sciences Brain Cerebellum Clinical trials Cognitive impairment Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dietary supplements Disease prevention elderly England Entorhinal cortex folic acid Fundamental and applied biological sciences. Psychology Genetics Hippocampus Hippocampus - drug effects Hippocampus - pathology homocysteine Homocysteine - blood Humans Image Processing, Computer-Assisted Linear Models Longitudinal Studies Magnetic Resonance Imaging Medical sciences Memory Nerve Degeneration - etiology Nerve Degeneration - pathology Nerve Degeneration - prevention & control Neurology Older adults Placebos pyridoxine risk factors Temporal Lobe - drug effects Temporal Lobe - pathology Vertebrates: nervous system and sense organs Vitamin B Vitamin B Complex - pharmacology Vitamin B Complex - therapeutic use vitamin B12
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