Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db⁻/db⁻ mouse, a type 2 diabetes model

Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and type 2 diabetes. Here we studied some phenotypic features of a well-established animal model of type 2 diabetes, the leptin receptor-deficient db⁻/db⁻ mouse, and also the effect of long-term (6 mo) treatment with...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (2), p.690-695
Hauptverfasser:	Shi, Tie-Jun Sten, Zhang, Ming-Dong, Zeberg, Hugo, Nilsson, Johanna, Grünler, Jacob, Liu, Su-Xing, Xiang, Qiong, Persson, Jonas, Fried, Kaj J., Catrina, Sergiu Bogdan, Watanabe, Masahiko, Århem, Peter, Brismar, Kerstin, Hökfelt, Tomas G. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors animal disease models Animal models Animals Antioxidants Biological and medical sciences Biological Sciences Blotting, Western coenzyme Q10 cold Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Diabetes Diabetes complications Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - pathology Diabetes. Impaired glucose tolerance Diabetic neuropathies Electric Stimulation Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes ganglia Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Genotype & phenotype Hyperalgesia - pathology Immunohistochemistry In Situ Hybridization leptin long term effects Medical sciences Mice Mice, Inbred C57BL Mice, Mutant Strains nerve tissue Nerves Nervous system (semeiology, syndromes) Neural Conduction - drug effects Neurochemistry Neurological disorders Neurology Neurons Neurons - drug effects noninsulin-dependent diabetes mellitus pain Peripheral nervous system diseases Peripheral Nervous System Diseases - etiology Peripheral Nervous System Diseases - prevention & control phospholipase C Phospholipase C beta - metabolism Proteins reactive oxygen species Receptors, Leptin - deficiency Receptors, Leptin - genetics Rodents Sciatic Nerve - injuries Sciatic Nerve - pathology Spinal ganglia Statistics, Nonparametric Type 1 diabetes mellitus Type 2 diabetes mellitus Ubiquinone - analogs & derivatives Ubiquinone - pharmacology
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