Polycistronic Expression of Human Platelet Factor 4 with Heparin-Neutralizing Activity in Escherichia coli

Human platelet factor 4 (hPF4) was evaluated as a clinical alternative to protamine for heparin neutralization, a protector against radiation injury and an anti-neoplastic. To achieve high-level expression of hPF4, expression vectors pET-28a(+)-nf PF4 (n=4, 5, 6) containing n tandem repeats of PF4 w...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2012, Vol.76 (10), p.1855-1860
Hauptverfasser:	DUAN, Yitao, WANG, Zhe, WU, Wei, FANG, Zhenjiang, HUANG, He
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-neoplastic Biological and medical sciences Colonies Enteropeptidase - metabolism Escherichia coli Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Gene Expression Genetic Engineering - methods Genetic Vectors - genetics Heparin - metabolism Humans neutralizing heparin platelet factor 4 Platelet Factor 4 - genetics Platelet Factor 4 - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism small pharmaceutical proteins tandem expression
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