CRISPR/Cas Adaptive Immune System of Pseudomonas aeruginosa Mediates Resistance to Naturally Occurring and Engineered Phages

Here we report the isolation of 6 temperate bacteriophages (phages) that are prevented from replicating within the laboratory strain Pseudomonas aeruginosa PA14 by the endogenous CRISPR/Cas system of this microbe. These phages are only the second identified group of naturally occurring phages demons...

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Veröffentlicht in:	Journal of Bacteriology 2012-11, Vol.194 (21), p.5728-5738
Hauptverfasser:	Cady, Kyle C, Bondy-Denomy, Joe, Heussler, Gary E, Davidson, Alan R, O'Toole, George A
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive immunity Bacteriology bacteriophages Biological and medical sciences DNA, Viral - chemistry DNA, Viral - genetics Drug resistance Fundamental and applied biological sciences. Psychology Genetic engineering Gram-negative bacteria Immune system Microbiology Miscellaneous Molecular Sequence Data mutants Mutation nucleotides Pseudomonas aeruginosa Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - physiology Pseudomonas aeruginosa - virology Pseudomonas Phages - genetics Pseudomonas Phages - growth & development Pseudomonas Phages - isolation & purification Recombination, Genetic Ribonucleic acid RNA screening Sequence Analysis, DNA Virology Virus Replication
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