Promoter methylation and loss of p16INK4a gene expression in head and neck cancer

Background Silencing of tumor suppressor genes plays a vital role in head and neck carcinogenesis. In this study we aimed to evaluate aberrant p16INK4a gene promoter methylation in patients with head and neck cancer. Methods Methylation of the gene was investigated by bisulfite modification/methylat...

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Veröffentlicht in:	Head & neck 2012-10, Vol.34 (10), p.1470-1475
Hauptverfasser:	Demokan, Semra, Chuang, Alice, Suoğlu, Yusufhan, Ulusan, Murat, Yalnız, Zubeyde, Califano, Joseph A., Dalay, Nejat
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences expression head and neck cancer Medical sciences methylation Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology p16INK4a Tumors
Online-Zugang:	Volltext
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