Transcriptional Repression Mediated by a TetR Family Protein, PfmR, from Thermus thermophilus HB8

PfmR is one of four TetR family transcriptional regulators found in the extremely thermophilic bacterium, Thermus thermophilus HB8. We identified three promoters with strong negative regulation by PfmR, both in vivo and in vitro. PfmR binds pseudopalindromic sequences, with the consensus sequence of...

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Veröffentlicht in:	Journal of Bacteriology 2012-09, Vol.194 (17), p.4630-4641
Hauptverfasser:	Agari, Yoshihiro, Sakamoto, Keiko, Kuramitsu, Seiki, Shinkai, Akeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acid sequences Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Base Sequence Binding sites Biological and medical sciences consensus sequence Crystal structure Deoxyribonucleic acid DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism fatty acid metabolism Fatty acids Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Bacterial genes Microbiology Miscellaneous Molecular Sequence Data nucleotide sequences phenylacetic acid Protein Structure, Secondary Repressor Proteins - chemistry Repressor Proteins - genetics Sequence Alignment Sequence Analysis, DNA Staphylococcus aureus Staphylococcus infections thermophilic bacteria Thermus thermophilus Thermus thermophilus - genetics transcription (genetics) transcription factors Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic X-ray diffraction
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