The Tyrosine Kinase Inhibitor Masitinib Blunts Airway Inflammation and Improves Associated Lung Mechanics in a Feline Model of Chronic Allergic Asthma

Background: Blockade of tyrosine kinase signaling by masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, can modulate allergic airway inflammation, but effects on lung mechanics have not been well characterized. We hypothesized masitinib would decrease airway eosinophilia and consequently im...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International archives of allergy and immunology 2012-01, Vol.158 (4), p.369-374
Hauptverfasser:	Lee-Fowler, Tekla M., Guntur, Vamsi, Dodam, John, Cohn, Leah A., DeClue, Amy E., Reinero, Carol R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - immunology Animals Anti-Asthmatic Agents - therapeutic use Asthma Asthma - chemically induced Asthma - drug therapy Asthma - immunology Biological and medical sciences Bronchoalveolar Lavage Fluid - immunology Cats Chronic Disease Chronic obstructive pulmonary disease, asthma Cynodon - immunology Eosinophils - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Immunoglobulin E - immunology Immunopathology Inflammation - drug therapy Inhibitor drugs Kinases Lung - drug effects Lung - immunology Lung - physiopathology Male Medical sciences Methacholine Chloride Original Paper Pneumology Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Thiazoles - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!