Acetone Precipitation of the Scrapie Agent Results in Successful Recovery of PrPSc but Decreased Infectivity

Bioassay is considered the most sensitive method for evaluating prion inactivation procedures. Because prions are resistant to methods effective at inactivating conventional microorganisms, prion inactivation research has focused on relatively harsh alternatives, such as concentrated sodium hypochlo...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2012-05, Vol.60 (18), p.4758-4762
Hauptverfasser:	Smith, J. D, Greenlee, J. J, Foster, G. H, Nicholson, E. M
Format:	Artikel
Sprache:	eng
Schlagworte:	acetone bioassays Biological and medical sciences brain Food industries Fundamental and applied biological sciences. Psychology mice microorganisms pathogenicity PrPSc proteins sodium hydroxide sodium hypochlorite Western blotting
Online-Zugang:	Volltext
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