Lactate inhibits Ca2+-activated Ca2+-channel activity from skeletal muscle sarcoplasmic reticulum
Terence G. Favero 1 , 2 , Anthony C. Zable 2 , David Colter 1 , and Jonathan J. Abramson 2 1 Department of Biology, University of Portland, Portland, Oregon 97203; and 2 Department of Physics, Portland State University, Portland, Oregon 97207 Received 6 June 1996; accepted in final form 3 October...
Gespeichert in:
| Veröffentlicht in: | Journal of applied physiology (1985) 1997-02, Vol.82 (2), p.447-452 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 452 |
|---|---|
| container_issue | 2 |
| container_start_page | 447 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 82 |
| creator | Favero, Terence G Zable, , Anthony C Colter, , David Abramson, Jonathan J |
| description | Terence G.
Favero 1 , 2 ,
Anthony C.
Zable 2 ,
David
Colter 1 , and
Jonathan J.
Abramson 2
1 Department of Biology, University of Portland,
Portland, Oregon 97203; and 2 Department of
Physics, Portland State University, Portland, Oregon 97207
Received 6 June 1996; accepted in final form 3 October 1996.
Favero, Terence G., Anthony C. Zable, David Colter, and
Jonathan J. Abramson. Lactate inhibits Ca 2+ -activated
Ca 2+ -channel activity from skeletal muscle sarcoplasmic
reticulum. J. Appl. Physiol. 82(2): 447-452, 1997. Sarcoplasmic reticulum (SR) Ca 2+ -release channel
function is modified by ligands that are generated during about of
exercise. We have examined the effects of lactate on Ca 2+ -
and caffeine-stimulated Ca 2+ release,
[ 3 H]ryanodine binding, and single
Ca 2+ -release channel activity of SR isolated from rabbit
white skeletal muscle. Lactate, at concentrations from 10 to 30 mM,
inhibited Ca 2+ - and caffeine-stimulated
[ 3 H]ryanodine binding to and inhibited Ca 2+ -
and caffeine-stimulated Ca 2+ release from SR vesicles.
Lactate also inhibited caffeine activation of single-channel activity
in bilayer reconstitution experiments. These findings suggest that
intense muscle activity, which generates high concentrations of
lactate, will disrupt excitation-contraction coupling. This may lead to
decreases in Ca 2+ transients promoting a decline in tension
development and contribute to muscle fatigue.
calcium; muscle fatigue; caffeine; lactate; skeletal muscle
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society |
| doi_str_mv | 10.1152/jappl.1997.82.2.447 |
| format | Article |
| fullrecord | <record><control><sourceid>pascalfrancis_highw</sourceid><recordid>TN_cdi_pascalfrancis_primary_2577770</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2577770</sourcerecordid><originalsourceid>FETCH-LOGICAL-h256t-cdf5ab6cc71f499584a092a6d4f6bdc3d4c92c02cd46412db06f0d8fb98a12943</originalsourceid><addsrcrecordid>eNp1kEtPwzAQhC0EKqXwC7jkgMQBJdiO8_ARVRSQKnEpZ2vjR-PiPBQnQP49FoUje1nt7DdzGISuCU4Iyej9AfreJYTzIilpQhPGihO0DB8akxyTU7QsiwzHRVYW5-jC-wPGhLGMLNCCY8YLmi4RbEGOMOrItrWt7OijNdC7OIj2I8jqeMoa2la76Ee24xyZoWsi_66dHsFFzeSl05GHQXa9A99YGQ16tHJyU3OJzgw4r69-9wq9bR536-d4-_r0sn7YxjXN8jGWymRQ5VIWxDDOs5IB5hRyxUxeKZkqJjmVmErFckaoqnBusCpNxUsglLN0hW6OuT14Cc4M0ErrRT_YBoZZ0KwIgwOWHrHa7utPO2jR17O3nev2s9hMzu301yhCtSUVVIRKRa9McN3-7wqw-KPTb8ivfIE</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Lactate inhibits Ca2+-activated Ca2+-channel activity from skeletal muscle sarcoplasmic reticulum</title><source>American Physiological Society</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Favero, Terence G ; Zable, , Anthony C ; Colter, , David ; Abramson, Jonathan J</creator><creatorcontrib>Favero, Terence G ; Zable, , Anthony C ; Colter, , David ; Abramson, Jonathan J</creatorcontrib><description>Terence G.
Favero 1 , 2 ,
Anthony C.
Zable 2 ,
David
Colter 1 , and
Jonathan J.
Abramson 2
1 Department of Biology, University of Portland,
Portland, Oregon 97203; and 2 Department of
Physics, Portland State University, Portland, Oregon 97207
Received 6 June 1996; accepted in final form 3 October 1996.
Favero, Terence G., Anthony C. Zable, David Colter, and
Jonathan J. Abramson. Lactate inhibits Ca 2+ -activated
Ca 2+ -channel activity from skeletal muscle sarcoplasmic
reticulum. J. Appl. Physiol. 82(2): 447-452, 1997. Sarcoplasmic reticulum (SR) Ca 2+ -release channel
function is modified by ligands that are generated during about of
exercise. We have examined the effects of lactate on Ca 2+ -
and caffeine-stimulated Ca 2+ release,
[ 3 H]ryanodine binding, and single
Ca 2+ -release channel activity of SR isolated from rabbit
white skeletal muscle. Lactate, at concentrations from 10 to 30 mM,
inhibited Ca 2+ - and caffeine-stimulated
[ 3 H]ryanodine binding to and inhibited Ca 2+ -
and caffeine-stimulated Ca 2+ release from SR vesicles.
Lactate also inhibited caffeine activation of single-channel activity
in bilayer reconstitution experiments. These findings suggest that
intense muscle activity, which generates high concentrations of
lactate, will disrupt excitation-contraction coupling. This may lead to
decreases in Ca 2+ transients promoting a decline in tension
development and contribute to muscle fatigue.
calcium; muscle fatigue; caffeine; lactate; skeletal muscle
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1997.82.2.447</identifier><identifier>PMID: 9049723</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Striated muscle. Tendons ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of applied physiology (1985), 1997-02, Vol.82 (2), p.447-452</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2577770$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Favero, Terence G</creatorcontrib><creatorcontrib>Zable, , Anthony C</creatorcontrib><creatorcontrib>Colter, , David</creatorcontrib><creatorcontrib>Abramson, Jonathan J</creatorcontrib><title>Lactate inhibits Ca2+-activated Ca2+-channel activity from skeletal muscle sarcoplasmic reticulum</title><title>Journal of applied physiology (1985)</title><description>Terence G.
Favero 1 , 2 ,
Anthony C.
Zable 2 ,
David
Colter 1 , and
Jonathan J.
Abramson 2
1 Department of Biology, University of Portland,
Portland, Oregon 97203; and 2 Department of
Physics, Portland State University, Portland, Oregon 97207
Received 6 June 1996; accepted in final form 3 October 1996.
Favero, Terence G., Anthony C. Zable, David Colter, and
Jonathan J. Abramson. Lactate inhibits Ca 2+ -activated
Ca 2+ -channel activity from skeletal muscle sarcoplasmic
reticulum. J. Appl. Physiol. 82(2): 447-452, 1997. Sarcoplasmic reticulum (SR) Ca 2+ -release channel
function is modified by ligands that are generated during about of
exercise. We have examined the effects of lactate on Ca 2+ -
and caffeine-stimulated Ca 2+ release,
[ 3 H]ryanodine binding, and single
Ca 2+ -release channel activity of SR isolated from rabbit
white skeletal muscle. Lactate, at concentrations from 10 to 30 mM,
inhibited Ca 2+ - and caffeine-stimulated
[ 3 H]ryanodine binding to and inhibited Ca 2+ -
and caffeine-stimulated Ca 2+ release from SR vesicles.
Lactate also inhibited caffeine activation of single-channel activity
in bilayer reconstitution experiments. These findings suggest that
intense muscle activity, which generates high concentrations of
lactate, will disrupt excitation-contraction coupling. This may lead to
decreases in Ca 2+ transients promoting a decline in tension
development and contribute to muscle fatigue.
calcium; muscle fatigue; caffeine; lactate; skeletal muscle
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Striated muscle. Tendons</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNp1kEtPwzAQhC0EKqXwC7jkgMQBJdiO8_ARVRSQKnEpZ2vjR-PiPBQnQP49FoUje1nt7DdzGISuCU4Iyej9AfreJYTzIilpQhPGihO0DB8akxyTU7QsiwzHRVYW5-jC-wPGhLGMLNCCY8YLmi4RbEGOMOrItrWt7OijNdC7OIj2I8jqeMoa2la76Ee24xyZoWsi_66dHsFFzeSl05GHQXa9A99YGQ16tHJyU3OJzgw4r69-9wq9bR536-d4-_r0sn7YxjXN8jGWymRQ5VIWxDDOs5IB5hRyxUxeKZkqJjmVmErFckaoqnBusCpNxUsglLN0hW6OuT14Cc4M0ErrRT_YBoZZ0KwIgwOWHrHa7utPO2jR17O3nev2s9hMzu301yhCtSUVVIRKRa9McN3-7wqw-KPTb8ivfIE</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>Favero, Terence G</creator><creator>Zable, , Anthony C</creator><creator>Colter, , David</creator><creator>Abramson, Jonathan J</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope></search><sort><creationdate>19970201</creationdate><title>Lactate inhibits Ca2+-activated Ca2+-channel activity from skeletal muscle sarcoplasmic reticulum</title><author>Favero, Terence G ; Zable, , Anthony C ; Colter, , David ; Abramson, Jonathan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h256t-cdf5ab6cc71f499584a092a6d4f6bdc3d4c92c02cd46412db06f0d8fb98a12943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Favero, Terence G</creatorcontrib><creatorcontrib>Zable, , Anthony C</creatorcontrib><creatorcontrib>Colter, , David</creatorcontrib><creatorcontrib>Abramson, Jonathan J</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Favero, Terence G</au><au>Zable, , Anthony C</au><au>Colter, , David</au><au>Abramson, Jonathan J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactate inhibits Ca2+-activated Ca2+-channel activity from skeletal muscle sarcoplasmic reticulum</atitle><jtitle>Journal of applied physiology (1985)</jtitle><date>1997-02-01</date><risdate>1997</risdate><volume>82</volume><issue>2</issue><spage>447</spage><epage>452</epage><pages>447-452</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Terence G.
Favero 1 , 2 ,
Anthony C.
Zable 2 ,
David
Colter 1 , and
Jonathan J.
Abramson 2
1 Department of Biology, University of Portland,
Portland, Oregon 97203; and 2 Department of
Physics, Portland State University, Portland, Oregon 97207
Received 6 June 1996; accepted in final form 3 October 1996.
Favero, Terence G., Anthony C. Zable, David Colter, and
Jonathan J. Abramson. Lactate inhibits Ca 2+ -activated
Ca 2+ -channel activity from skeletal muscle sarcoplasmic
reticulum. J. Appl. Physiol. 82(2): 447-452, 1997. Sarcoplasmic reticulum (SR) Ca 2+ -release channel
function is modified by ligands that are generated during about of
exercise. We have examined the effects of lactate on Ca 2+ -
and caffeine-stimulated Ca 2+ release,
[ 3 H]ryanodine binding, and single
Ca 2+ -release channel activity of SR isolated from rabbit
white skeletal muscle. Lactate, at concentrations from 10 to 30 mM,
inhibited Ca 2+ - and caffeine-stimulated
[ 3 H]ryanodine binding to and inhibited Ca 2+ -
and caffeine-stimulated Ca 2+ release from SR vesicles.
Lactate also inhibited caffeine activation of single-channel activity
in bilayer reconstitution experiments. These findings suggest that
intense muscle activity, which generates high concentrations of
lactate, will disrupt excitation-contraction coupling. This may lead to
decreases in Ca 2+ transients promoting a decline in tension
development and contribute to muscle fatigue.
calcium; muscle fatigue; caffeine; lactate; skeletal muscle
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9049723</pmid><doi>10.1152/jappl.1997.82.2.447</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1997-02, Vol.82 (2), p.447-452 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_2577770 |
| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Fundamental and applied biological sciences. Psychology Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system |
| title | Lactate inhibits Ca2+-activated Ca2+-channel activity from skeletal muscle sarcoplasmic reticulum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T00%3A41%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pascalfrancis_highw&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lactate%20inhibits%20Ca2+-activated%20Ca2+-channel%20activity%20from%20skeletal%20muscle%20sarcoplasmic%20reticulum&rft.jtitle=Journal%20of%20applied%20physiology%20(1985)&rft.au=Favero,%20Terence%20G&rft.date=1997-02-01&rft.volume=82&rft.issue=2&rft.spage=447&rft.epage=452&rft.pages=447-452&rft.issn=8750-7587&rft.eissn=1522-1601&rft.coden=JAPHEV&rft_id=info:doi/10.1152/jappl.1997.82.2.447&rft_dat=%3Cpascalfrancis_highw%3E2577770%3C/pascalfrancis_highw%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/9049723&rfr_iscdi=true |