Comparative study of hydroxyapatite from eggshells and synthetic hydroxyapatite for bone regeneration
Objectives The objective of this study was to evaluate the physical properties of synthetic hydroxyapatite (sHA) and hydroxyapatite from eggshells (eHA) by Fourier-transform infrared (FT-IR) and x-ray diffraction (XRD) and to compare the regenerative ability of the bone using sHA and eHA in a rabbit...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2012-03, Vol.113 (3), p.348-355 |
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| creator | Lee, Sang-Woon, DDS Kim, Seong-Gon, DDS, PhD Balázsi, Csaba, PhD Chae, Weon-Sik, PhD Lee, Hee-Ok |
| description | Objectives The objective of this study was to evaluate the physical properties of synthetic hydroxyapatite (sHA) and hydroxyapatite from eggshells (eHA) by Fourier-transform infrared (FT-IR) and x-ray diffraction (XRD) and to compare the regenerative ability of the bone using sHA and eHA in a rabbit calvarial defect model. Study Design FT-IR and XRD were used to compare the physical properties of sHA and eHA. sHA was purchased from Sigma, and eHA was kindly donated from the Hungarian academy of science. Sixteen New Zealand white rabbits were used for the animal study. After the formation of a bilateral parietal bony defect (diameter 8.0 mm), either sHA or eHA was grafted into the defect. The defect in the control was left unfilled. Bone regeneration was evaluated by histomorphometry at 4 and 8 weeks after the operation. Results The peak broadening of the XRD experiments were in agreement with scanning electron microscope observation; the sHA had a smaller granule size than the eHA. The eHA had impurities phases of CaO (International Center for Diffraction Data (ICDD) 075-0264) and Ca(OH)2 (ICDD 072-0156). Total new bone was 17.11 ± 10.24% in the control group, 28.81 ± 12.63% in sHA group, and 25.68 ± 10.89% in eHA group at 4 weeks after the operation. The difference was not statistically significant ( P > .05). Total new bone at 8 weeks after the operation was 27.50 ± 10.89% in the control group, 38.62 ± 17.42% in sHA group, and 41.99 ± 8.44% in the eHA group. When comparing the sHA group to the control group, the difference was not statistically significant ( P > .05). However, the eHA group was significantly different from the control group ( P = .038). When comparing the eHA group to the sHA group, the difference was not statistically significant ( P > .05). Conclusions Both types of HA showed higher bone formation than the unfilled control. However, eHA had significantly higher bone formation than the unfilled control at 8 weeks after operation. |
| doi_str_mv | 10.1016/j.tripleo.2011.03.033 |
| format | Article |
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Study Design FT-IR and XRD were used to compare the physical properties of sHA and eHA. sHA was purchased from Sigma, and eHA was kindly donated from the Hungarian academy of science. Sixteen New Zealand white rabbits were used for the animal study. After the formation of a bilateral parietal bony defect (diameter 8.0 mm), either sHA or eHA was grafted into the defect. The defect in the control was left unfilled. Bone regeneration was evaluated by histomorphometry at 4 and 8 weeks after the operation. Results The peak broadening of the XRD experiments were in agreement with scanning electron microscope observation; the sHA had a smaller granule size than the eHA. The eHA had impurities phases of CaO (International Center for Diffraction Data (ICDD) 075-0264) and Ca(OH)2 (ICDD 072-0156). Total new bone was 17.11 ± 10.24% in the control group, 28.81 ± 12.63% in sHA group, and 25.68 ± 10.89% in eHA group at 4 weeks after the operation. The difference was not statistically significant ( P > .05). Total new bone at 8 weeks after the operation was 27.50 ± 10.89% in the control group, 38.62 ± 17.42% in sHA group, and 41.99 ± 8.44% in the eHA group. When comparing the sHA group to the control group, the difference was not statistically significant ( P > .05). However, the eHA group was significantly different from the control group ( P = .038). When comparing the eHA group to the sHA group, the difference was not statistically significant ( P > .05). Conclusions Both types of HA showed higher bone formation than the unfilled control. However, eHA had significantly higher bone formation than the unfilled control at 8 weeks after operation.</description><identifier>ISSN: 2212-4403</identifier><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 2212-4411</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/j.tripleo.2011.03.033</identifier><identifier>PMID: 22676827</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Animals ; Biological and medical sciences ; Bone Regeneration - drug effects ; Bone Substitutes - chemical synthesis ; Bone Substitutes - pharmacology ; Crystallography, X-Ray ; Dentistry ; Durapatite - chemical synthesis ; Durapatite - pharmacology ; Egg Shell - chemistry ; Medical sciences ; Otorhinolaryngology. Stomatology ; Rabbits ; Skull - injuries ; Spectroscopy, Fourier Transform Infrared ; Surgery</subject><ispartof>Oral surgery, oral medicine, oral pathology and oral radiology, 2012-03, Vol.113 (3), p.348-355</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-3118e539f19c4592b18537e76388bd8f27628e4c2ec87f776073a619b9ea6b383</citedby><cites>FETCH-LOGICAL-c450t-3118e539f19c4592b18537e76388bd8f27628e4c2ec87f776073a619b9ea6b383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25517931$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22676827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sang-Woon, DDS</creatorcontrib><creatorcontrib>Kim, Seong-Gon, DDS, PhD</creatorcontrib><creatorcontrib>Balázsi, Csaba, PhD</creatorcontrib><creatorcontrib>Chae, Weon-Sik, PhD</creatorcontrib><creatorcontrib>Lee, Hee-Ok</creatorcontrib><title>Comparative study of hydroxyapatite from eggshells and synthetic hydroxyapatite for bone regeneration</title><title>Oral surgery, oral medicine, oral pathology and oral radiology</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol</addtitle><description>Objectives The objective of this study was to evaluate the physical properties of synthetic hydroxyapatite (sHA) and hydroxyapatite from eggshells (eHA) by Fourier-transform infrared (FT-IR) and x-ray diffraction (XRD) and to compare the regenerative ability of the bone using sHA and eHA in a rabbit calvarial defect model. Study Design FT-IR and XRD were used to compare the physical properties of sHA and eHA. sHA was purchased from Sigma, and eHA was kindly donated from the Hungarian academy of science. Sixteen New Zealand white rabbits were used for the animal study. After the formation of a bilateral parietal bony defect (diameter 8.0 mm), either sHA or eHA was grafted into the defect. The defect in the control was left unfilled. Bone regeneration was evaluated by histomorphometry at 4 and 8 weeks after the operation. Results The peak broadening of the XRD experiments were in agreement with scanning electron microscope observation; the sHA had a smaller granule size than the eHA. The eHA had impurities phases of CaO (International Center for Diffraction Data (ICDD) 075-0264) and Ca(OH)2 (ICDD 072-0156). Total new bone was 17.11 ± 10.24% in the control group, 28.81 ± 12.63% in sHA group, and 25.68 ± 10.89% in eHA group at 4 weeks after the operation. The difference was not statistically significant ( P > .05). Total new bone at 8 weeks after the operation was 27.50 ± 10.89% in the control group, 38.62 ± 17.42% in sHA group, and 41.99 ± 8.44% in the eHA group. When comparing the sHA group to the control group, the difference was not statistically significant ( P > .05). However, the eHA group was significantly different from the control group ( P = .038). When comparing the eHA group to the sHA group, the difference was not statistically significant ( P > .05). Conclusions Both types of HA showed higher bone formation than the unfilled control. However, eHA had significantly higher bone formation than the unfilled control at 8 weeks after operation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Regeneration - drug effects</subject><subject>Bone Substitutes - chemical synthesis</subject><subject>Bone Substitutes - pharmacology</subject><subject>Crystallography, X-Ray</subject><subject>Dentistry</subject><subject>Durapatite - chemical synthesis</subject><subject>Durapatite - pharmacology</subject><subject>Egg Shell - chemistry</subject><subject>Medical sciences</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Rabbits</subject><subject>Skull - injuries</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Surgery</subject><issn>2212-4403</issn><issn>1079-2104</issn><issn>2212-4411</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFr3DAQhUVoSUKan9DiS6GX3WokW7IvLWVpm0Cgh6RnIcvjXW1tyZXkEP_7atltCu2hYkBi-N6b4SFCXgNdAwXxfr9OwU4D-jWjAGvKc_EzcskYsFVZArx4flN-Qa5j3NN8RNaW7JxcMCakqJm8JLjx46SDTvYRi5jmbil8X-yWLvinRU-5n7Dogx8L3G7jDochFtp1RVxc2mGy5h_Wh6L1DouAW3R4cPbuFXnZ6yHi9em-It-_fH7Y3Kzuvn293Xy6W5myomnFAWqseNNDkxsNa6GuuEQpeF23Xd0zKViNpWFoatlLKajkWkDTNqhFy2t-Rd4dfafgf84YkxptNHlp7dDPUeXwGgGiqlhGqyNqgo8xYK-mYEcdlgwdOKH26hSyOoSsKM_Fs-7NacTcjtg9q35HmoG3J0BHo4c-aGds_MNVFciGQ-Y-HjnMgTxaDCoai85gZwOapDpv_7vKh78czGCdzUN_4IJx7-fgctoKVGSKqnugsmFA8_eglFEJ_BeGPrLq</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Lee, Sang-Woon, DDS</creator><creator>Kim, Seong-Gon, DDS, PhD</creator><creator>Balázsi, Csaba, PhD</creator><creator>Chae, Weon-Sik, PhD</creator><creator>Lee, Hee-Ok</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Comparative study of hydroxyapatite from eggshells and synthetic hydroxyapatite for bone regeneration</title><author>Lee, Sang-Woon, DDS ; Kim, Seong-Gon, DDS, PhD ; Balázsi, Csaba, PhD ; Chae, Weon-Sik, PhD ; Lee, Hee-Ok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-3118e539f19c4592b18537e76388bd8f27628e4c2ec87f776073a619b9ea6b383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Regeneration - drug effects</topic><topic>Bone Substitutes - chemical synthesis</topic><topic>Bone Substitutes - pharmacology</topic><topic>Crystallography, X-Ray</topic><topic>Dentistry</topic><topic>Durapatite - chemical synthesis</topic><topic>Durapatite - pharmacology</topic><topic>Egg Shell - chemistry</topic><topic>Medical sciences</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Rabbits</topic><topic>Skull - injuries</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sang-Woon, DDS</creatorcontrib><creatorcontrib>Kim, Seong-Gon, DDS, PhD</creatorcontrib><creatorcontrib>Balázsi, Csaba, PhD</creatorcontrib><creatorcontrib>Chae, Weon-Sik, PhD</creatorcontrib><creatorcontrib>Lee, Hee-Ok</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology and oral radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sang-Woon, DDS</au><au>Kim, Seong-Gon, DDS, PhD</au><au>Balázsi, Csaba, PhD</au><au>Chae, Weon-Sik, PhD</au><au>Lee, Hee-Ok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative study of hydroxyapatite from eggshells and synthetic hydroxyapatite for bone regeneration</atitle><jtitle>Oral surgery, oral medicine, oral pathology and oral radiology</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>113</volume><issue>3</issue><spage>348</spage><epage>355</epage><pages>348-355</pages><issn>2212-4403</issn><issn>1079-2104</issn><eissn>2212-4411</eissn><eissn>1528-395X</eissn><abstract>Objectives The objective of this study was to evaluate the physical properties of synthetic hydroxyapatite (sHA) and hydroxyapatite from eggshells (eHA) by Fourier-transform infrared (FT-IR) and x-ray diffraction (XRD) and to compare the regenerative ability of the bone using sHA and eHA in a rabbit calvarial defect model. Study Design FT-IR and XRD were used to compare the physical properties of sHA and eHA. sHA was purchased from Sigma, and eHA was kindly donated from the Hungarian academy of science. Sixteen New Zealand white rabbits were used for the animal study. After the formation of a bilateral parietal bony defect (diameter 8.0 mm), either sHA or eHA was grafted into the defect. The defect in the control was left unfilled. Bone regeneration was evaluated by histomorphometry at 4 and 8 weeks after the operation. Results The peak broadening of the XRD experiments were in agreement with scanning electron microscope observation; the sHA had a smaller granule size than the eHA. The eHA had impurities phases of CaO (International Center for Diffraction Data (ICDD) 075-0264) and Ca(OH)2 (ICDD 072-0156). Total new bone was 17.11 ± 10.24% in the control group, 28.81 ± 12.63% in sHA group, and 25.68 ± 10.89% in eHA group at 4 weeks after the operation. The difference was not statistically significant ( P > .05). Total new bone at 8 weeks after the operation was 27.50 ± 10.89% in the control group, 38.62 ± 17.42% in sHA group, and 41.99 ± 8.44% in the eHA group. When comparing the sHA group to the control group, the difference was not statistically significant ( P > .05). However, the eHA group was significantly different from the control group ( P = .038). When comparing the eHA group to the sHA group, the difference was not statistically significant ( P > .05). Conclusions Both types of HA showed higher bone formation than the unfilled control. However, eHA had significantly higher bone formation than the unfilled control at 8 weeks after operation.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22676827</pmid><doi>10.1016/j.tripleo.2011.03.033</doi><tpages>8</tpages></addata></record> |
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| ispartof | Oral surgery, oral medicine, oral pathology and oral radiology, 2012-03, Vol.113 (3), p.348-355 |
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| subjects | Animals Biological and medical sciences Bone Regeneration - drug effects Bone Substitutes - chemical synthesis Bone Substitutes - pharmacology Crystallography, X-Ray Dentistry Durapatite - chemical synthesis Durapatite - pharmacology Egg Shell - chemistry Medical sciences Otorhinolaryngology. Stomatology Rabbits Skull - injuries Spectroscopy, Fourier Transform Infrared Surgery |
| title | Comparative study of hydroxyapatite from eggshells and synthetic hydroxyapatite for bone regeneration |
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