Effects on Growth by Changes of the Balance between GreA, GreB, and DksA Suggest Mutual Competition and Functional Redundancy in Escherichia coli

It is well known that ppGpp and DksA interact with bacterial RNA polymerase (RNAP) to alter promoter activity. This study suggests that GreA plays a major role and GreB plays a minor role in the ppGpp-DksA regulatory network. We present evidence that DksA and GreA/GreB are redundant and/or share sim...

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Veröffentlicht in:Journal of Bacteriology 2012-01, Vol.194 (2), p.261-273
Hauptverfasser: Vinella, Daniel, Potrykus, Katarzyna, Murphy, Helen, Cashel, Michael
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Sprache:eng
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