Integrated Bimodal Waveguide Interferometric Biosensor for Label-Free Analysis
The performance of an interferometric device based on integrated Bimodal Waveguides (BiMW) for sensing is demonstrated. The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5·10 - 7 RIU for homogeneous sensing, rendering in a very high sensitive device....
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| Veröffentlicht in: | Journal of lightwave technology 2011-07, Vol.29 (13), p.1926-1930 |
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| container_end_page | 1930 |
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| container_issue | 13 |
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| container_title | Journal of lightwave technology |
| container_volume | 29 |
| creator | Zinoviev, K E Gonzalez-Guerrero, A B Dominguez, C Lechuga, L M |
| description | The performance of an interferometric device based on integrated Bimodal Waveguides (BiMW) for sensing is demonstrated. The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5·10 - 7 RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. Due to their simplicity, the interferometric devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing them as a powerful instrument for biochemical analysis. |
| doi_str_mv | 10.1109/JLT.2011.2150734 |
| format | Article |
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The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5·10 - 7 RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. 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The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5·10 - 7 RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. Due to their simplicity, the interferometric devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing them as a powerful instrument for biochemical analysis.</description><subject>Applied sciences</subject><subject>Bimodal waveguide</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biosensors</subject><subject>Biotechnology</subject><subject>Circuit properties</subject><subject>Detection</subject><subject>Devices</subject><subject>Electric, optical and optoelectronic circuits</subject><subject>Electronics</subject><subject>evanescent wave detection</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General equipment and techniques</subject><subject>Instruments, apparatus, components and techniques common to several branches of physics and astronomy</subject><subject>integrated optics</subject><subject>Integrated optics. Optical fibers and wave guides</subject><subject>Interferometers</subject><subject>Methods. Procedures. Technologies</subject><subject>Monitoring</subject><subject>Optical and optoelectronic circuits</subject><subject>optical biosensors</subject><subject>Optical interferometry</subject><subject>Optical sensors</subject><subject>Optical waveguides</subject><subject>Physics</subject><subject>Refractive index</subject><subject>Rendering</subject><subject>Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing</subject><subject>Temperature sensors</subject><subject>Various methods and equipments</subject><subject>Waveguides</subject><issn>0733-8724</issn><issn>1558-2213</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNpdkM1Lw0AQxRdRsFbvgpcgCF5Sd_Yjmz3WYrVS9FLxuGyzsyUlTepuKvS_N6GlBw_DwLzfmxkeIbdARwBUP73PFyNGAUYMJFVcnJEBSJmnjAE_J4NuxNNcMXFJrmJcUwpC5GpAPmZ1i6tgW3TJc7lpnK2Sb_uLq13pMOnF4DE0G2xDWXREE7GOTUh8V3O7xCqdBsRkXNtqH8t4TS68rSLeHPuQfE1fFpO3dP75OpuM52khBGvTzCtn89wx7fhSLT0U3DnvKdMyp5p3ImVAOTAF2jrNQOVOMivAAs2U53xIHg97t6H52WFszaaMBVaVrbHZRQOZAi6Ekj16_w9dN7vQ_RuNBpkppXPZQfQAFaGJMaA321BubNgboKbP13T5mj5fc8y3szwc99pY2MoHWxdlPPmYEIJK3d-_O3AlIp5kqTIpION_P8aB3Q</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Zinoviev, K E</creator><creator>Gonzalez-Guerrero, A B</creator><creator>Dominguez, C</creator><creator>Lechuga, L M</creator><general>IEEE</general><general>Institute of Electrical and Electronics Engineers</general><general>The Institute of Electrical and Electronics Engineers, Inc. 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| source | IEEE Electronic Library (IEL) |
| subjects | Applied sciences Bimodal waveguide Biochemistry Biological and medical sciences Biosensors Biotechnology Circuit properties Detection Devices Electric, optical and optoelectronic circuits Electronics evanescent wave detection Exact sciences and technology Fundamental and applied biological sciences. Psychology General equipment and techniques Instruments, apparatus, components and techniques common to several branches of physics and astronomy integrated optics Integrated optics. Optical fibers and wave guides Interferometers Methods. Procedures. Technologies Monitoring Optical and optoelectronic circuits optical biosensors Optical interferometry Optical sensors Optical waveguides Physics Refractive index Rendering Sensors (chemical, optical, electrical, movement, gas, etc.) remote sensing Temperature sensors Various methods and equipments Waveguides |
| title | Integrated Bimodal Waveguide Interferometric Biosensor for Label-Free Analysis |
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