Clinicopathological and Prognostic Value of MicroRNA-21 and MicroRNA-155 in Colorectal Cancer
Objective: The clinical significance of microRNA-21 (miR-21) and miR-155 in colorectal cancer (CRC) patients remains elusive. In this study, we established the prognostic value of miR-21 and miR-155 using clinical samples from CRC patients. Furthermore, relationships between these microRNAs and targ...
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| Veröffentlicht in: | Oncology 2010-01, Vol.79 (3-4), p.313-320 |
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| creator | Shibuya, Hajime Iinuma, Hisae Shimada, Ryu Horiuchi, Atsushi Watanabe, Toshiaki |
| description | Objective: The clinical significance of microRNA-21 (miR-21) and miR-155 in colorectal cancer (CRC) patients remains elusive. In this study, we established the prognostic value of miR-21 and miR-155 using clinical samples from CRC patients. Furthermore, relationships between these microRNAs and target genes (PDCD4 and TP53INP1 mRNAs) were examined. Methods: miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays, and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR (RT-PCR). Results: High miR-21 expression was significantly associated with venous invasion, liver metastasis and tumor stage, and high miR-155 expression was significantly correlated with lymph node metastases. The overall (OS) and disease-free survival (DFS) rates of patients with high miR-21 expression were significantly worse than those of patients with low miR-21 expression. The OS and DFS of patients with high miR-155 expression were also significantly worse than those in patients with low miR-155 expression. miR-21 and miR-155 expression levels in CRC tissue were independent prognostic factors for OS and DFS. Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA, and miR-155 and TP53INP1 mRNA. Conclusion: Increases in miR-21 and miR-155 expression may represent effective biomarkers for the prediction of a poor prognosis. |
| doi_str_mv | 10.1159/000323283 |
| format | Article |
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In this study, we established the prognostic value of miR-21 and miR-155 using clinical samples from CRC patients. Furthermore, relationships between these microRNAs and target genes (PDCD4 and TP53INP1 mRNAs) were examined. Methods: miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays, and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR (RT-PCR). Results: High miR-21 expression was significantly associated with venous invasion, liver metastasis and tumor stage, and high miR-155 expression was significantly correlated with lymph node metastases. The overall (OS) and disease-free survival (DFS) rates of patients with high miR-21 expression were significantly worse than those of patients with low miR-21 expression. The OS and DFS of patients with high miR-155 expression were also significantly worse than those in patients with low miR-155 expression. miR-21 and miR-155 expression levels in CRC tissue were independent prognostic factors for OS and DFS. Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA, and miR-155 and TP53INP1 mRNA. Conclusion: Increases in miR-21 and miR-155 expression may represent effective biomarkers for the prediction of a poor prognosis.</description><identifier>ISSN: 0030-2414</identifier><identifier>EISSN: 1423-0232</identifier><identifier>DOI: 10.1159/000323283</identifier><identifier>PMID: 21412018</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Apoptosis Regulatory Proteins - genetics ; Biological and medical sciences ; Biomarkers ; Carrier Proteins - genetics ; Clinical Translational Research ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Heat-Shock Proteins - genetics ; Humans ; Liver Neoplasms - drug therapy ; Liver Neoplasms - secondary ; Lymphatic Metastasis ; Male ; Medical prognosis ; Medical sciences ; MicroRNAs - genetics ; Middle Aged ; Neoplasm Invasiveness ; Peritoneal Neoplasms - drug therapy ; Peritoneal Neoplasms - secondary ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonucleic acid ; RNA ; RNA, Messenger - genetics ; RNA-Binding Proteins - genetics ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Rate ; Tumors</subject><ispartof>Oncology, 2010-01, Vol.79 (3-4), p.313-320</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-afc45fe6c14f4368eade1dc5967a12fc9513c2b8153b23dac70a66106a11df893</citedby><cites>FETCH-LOGICAL-c428t-afc45fe6c14f4368eade1dc5967a12fc9513c2b8153b23dac70a66106a11df893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24029812$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21412018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shibuya, Hajime</creatorcontrib><creatorcontrib>Iinuma, Hisae</creatorcontrib><creatorcontrib>Shimada, Ryu</creatorcontrib><creatorcontrib>Horiuchi, Atsushi</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><title>Clinicopathological and Prognostic Value of MicroRNA-21 and MicroRNA-155 in Colorectal Cancer</title><title>Oncology</title><addtitle>Oncology</addtitle><description>Objective: The clinical significance of microRNA-21 (miR-21) and miR-155 in colorectal cancer (CRC) patients remains elusive. In this study, we established the prognostic value of miR-21 and miR-155 using clinical samples from CRC patients. Furthermore, relationships between these microRNAs and target genes (PDCD4 and TP53INP1 mRNAs) were examined. Methods: miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays, and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR (RT-PCR). Results: High miR-21 expression was significantly associated with venous invasion, liver metastasis and tumor stage, and high miR-155 expression was significantly correlated with lymph node metastases. The overall (OS) and disease-free survival (DFS) rates of patients with high miR-21 expression were significantly worse than those of patients with low miR-21 expression. The OS and DFS of patients with high miR-155 expression were also significantly worse than those in patients with low miR-155 expression. miR-21 and miR-155 expression levels in CRC tissue were independent prognostic factors for OS and DFS. Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA, and miR-155 and TP53INP1 mRNA. Conclusion: Increases in miR-21 and miR-155 expression may represent effective biomarkers for the prediction of a poor prognosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis Regulatory Proteins - genetics</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Carrier Proteins - genetics</subject><subject>Clinical Translational Research</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Humans</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - secondary</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Peritoneal Neoplasms - drug therapy</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>Prognosis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>RNA-Binding Proteins - genetics</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0030-2414</issn><issn>1423-0232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0M1LwzAYBvAgis7pwbtIEUQ8VPPmo02Po_gF8wNRb1KyNJnRrplJe_C_N7o5wVN4w4_nTR6E9gCfAvDiDGNMCSWCrqEBMEJTHKd1NIjXOCUM2BbaDuEtspyzbBNtEWBAMIgBeikb21rl5rJ7dY2bWiWbRLZ1cu_dtHWhsyp5lk2vE2eSG6u8e7gdpQR-zGoGzhPbJmVM8Fp1MaKUrdJ-B20Y2QS9uzyH6Oni_LG8Ssd3l9flaJwqRkSXSqMYNzpTwAyjmdCy1lArXmS5BGJUwYEqMhHA6YTQWqocyywDnEmA2oiCDtHxInfu3UevQ1fNbFC6aWSrXR8qwQtW5DllUR7-k2-u9218XCUyzhnncckQnSxQ_F4IXptq7u1M-s8KcPXdeLVqPNqDZWA_mel6JX8rjuBoCWSI5Rofm7HhzzFMCgEkuv2Fe5d-qv0KLPd8AUs9ji0</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Shibuya, Hajime</creator><creator>Iinuma, Hisae</creator><creator>Shimada, Ryu</creator><creator>Horiuchi, Atsushi</creator><creator>Watanabe, Toshiaki</creator><general>Karger</general><general>S. 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Liver. Pancreas. Abdomen</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Humans</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - secondary</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Peritoneal Neoplasms - drug therapy</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>Prognosis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>RNA-Binding Proteins - genetics</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shibuya, Hajime</creatorcontrib><creatorcontrib>Iinuma, Hisae</creatorcontrib><creatorcontrib>Shimada, Ryu</creatorcontrib><creatorcontrib>Horiuchi, Atsushi</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shibuya, Hajime</au><au>Iinuma, Hisae</au><au>Shimada, Ryu</au><au>Horiuchi, Atsushi</au><au>Watanabe, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological and Prognostic Value of MicroRNA-21 and MicroRNA-155 in Colorectal Cancer</atitle><jtitle>Oncology</jtitle><addtitle>Oncology</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>79</volume><issue>3-4</issue><spage>313</spage><epage>320</epage><pages>313-320</pages><issn>0030-2414</issn><eissn>1423-0232</eissn><abstract>Objective: The clinical significance of microRNA-21 (miR-21) and miR-155 in colorectal cancer (CRC) patients remains elusive. In this study, we established the prognostic value of miR-21 and miR-155 using clinical samples from CRC patients. Furthermore, relationships between these microRNAs and target genes (PDCD4 and TP53INP1 mRNAs) were examined. Methods: miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays, and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR (RT-PCR). Results: High miR-21 expression was significantly associated with venous invasion, liver metastasis and tumor stage, and high miR-155 expression was significantly correlated with lymph node metastases. The overall (OS) and disease-free survival (DFS) rates of patients with high miR-21 expression were significantly worse than those of patients with low miR-21 expression. The OS and DFS of patients with high miR-155 expression were also significantly worse than those in patients with low miR-155 expression. miR-21 and miR-155 expression levels in CRC tissue were independent prognostic factors for OS and DFS. Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA, and miR-155 and TP53INP1 mRNA. Conclusion: Increases in miR-21 and miR-155 expression may represent effective biomarkers for the prediction of a poor prognosis.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>21412018</pmid><doi>10.1159/000323283</doi><tpages>8</tpages></addata></record> |
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| ispartof | Oncology, 2010-01, Vol.79 (3-4), p.313-320 |
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| subjects | Adult Aged Aged, 80 and over Apoptosis Regulatory Proteins - genetics Biological and medical sciences Biomarkers Carrier Proteins - genetics Clinical Translational Research Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Heat-Shock Proteins - genetics Humans Liver Neoplasms - drug therapy Liver Neoplasms - secondary Lymphatic Metastasis Male Medical prognosis Medical sciences MicroRNAs - genetics Middle Aged Neoplasm Invasiveness Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - secondary Prognosis Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA, Messenger - genetics RNA-Binding Proteins - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Tumors |
| title | Clinicopathological and Prognostic Value of MicroRNA-21 and MicroRNA-155 in Colorectal Cancer |
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