Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAFV600E mutation

BRAFV600E mutations are found in 10% of colorectal cancers (CRCs). The low frequency of this mutation therefore makes it a challenging target for drug development, unless subsets of patients with higher rates of BRAFV600E can be defined. Knowledge of the concordance between primary–metastasis pairs...

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Veröffentlicht in:	International journal of cancer 2011-05, Vol.128 (9), p.2075-2084
Hauptverfasser:	Tie, Jeanne, Gibbs, Peter, Lipton, Lara, Christie, Michael, Jorissen, Robert N., Burgess, Antony W., Croxford, Matthew, Jones, Ian, Langland, Rachel, Kosmider, Suzanne, McKay, Daniel, Bollag, Gideon, Nolop, Keith, Sieber, Oliver M., Desai, Jayesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences BRAF colorectal cancer Gastroenterology. Liver. Pancreas. Abdomen Medical sciences prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
Online-Zugang:	Volltext
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