Differential Effects in Vivo of Thyroid Hormone on the Expression of Surfactant Phospholipid, Surfactant Protein mRNA and Antioxidant Enzyme mRNA in Fetal Rat Lung

Antenatal administration of triiodo-L-thyronine (T3) to late gestation rats resulted in decreased lung antioxidant enzyme (AOE) activity but increased surfactant phospholipids. In fetal rat lung explant cultures, T3 decreased the expression of surfactant proteins (SP) A and B. There have been no rep...

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Veröffentlicht in:	Experimental lung research 1998, Vol.24 (5), p.641-657
Hauptverfasser:	Ramadurai, Sujatha M., Nielsen, Heber C., Chen, Youwei, Hatzis, Dimitrios, Sosenko, Llene R. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Animals antioxidant enzymes (ADE) Biological and medical sciences Blotting, Northern Catalase - genetics Catalase - metabolism DNA Primers - chemistry Female Fundamental and applied biological sciences. Psychology Gene Expression Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Lung - drug effects Lung - embryology Lung - metabolism Oxidoreductases - genetics Oxidoreductases - metabolism Phosphatidylcholines - metabolism Phospholipids - genetics Phospholipids - metabolism Polymerase Chain Reaction Pregnancy Pulmonary Surfactants - genetics Pulmonary Surfactants - metabolism Rats Rats, Sprague-Dawley Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Ribosomal Proteins - metabolism RNA, Messenger - metabolism Superoxide Dismutase - genetics Superoxide Dismutase - metabolism surfactant protein genes (SP) tri-iodothyronine (T Triiodothyronine - pharmacology Vertebrates: respiratory system
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