N-methyl-4-isoleucine cyclosporine attenuates CCl4-induced liver fibrosis in rats by interacting with cyclophilin B and D

Background and Aim:  N‐methyl‐4‐isoleucine cyclosporine (NIM811), a new analogue of cyclosporine A, can inhibit collagen deposition in vitro and reduce liver necrosis in a bile‐duct‐ligation animal model. However, whether NIM811 effects on CCl4‐induced rat liver fibrosis, and the related mechanism h...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2011-03, Vol.26 (3), p.558-567
Hauptverfasser:	Wang, Hui, Zhang, Yuguo, Wang, Tailing, You, Hong, Jia, Jidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences cyclophilin B cyclophilin D Gastroenterology. Liver. Pancreas. Abdomen liver fibrosis Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences N-methyl-4-isoleucine cyclosporine Other diseases. Semiology
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