Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress
The mortality of individuals suffering from depression has been increasing, especially post-menopausal women; therefore, their care and treatment are important to maintain a high quality of life. In the present study, we evaluated the antidepressant-like effects of a major isoflavonoid, genistein (4...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (10), p.2005-2010 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | KAGEYAMA, Aya SAKAKIBARA, Hiroyuki ZHOU, Wenjun YOSHIOKA, Miyuki OHSUMI, Miho SHIMOI, Kayoko YOKOGOSHI, Hidehiko |
| description | The mortality of individuals suffering from depression has been increasing, especially post-menopausal women; therefore, their care and treatment are important to maintain a high quality of life. In the present study, we evaluated the antidepressant-like effects of a major isoflavonoid, genistein (4′,5,7-trihydroxyisoflavone), using a behavioral model of depression, the forced swimming test (FST), in ovariectomized rats. Daily administration of genistein to ovariectomized rats at a dosage of 10 mg/kg of body weight/d for 14 d significantly reduced the immobility time during the FST without changing motor dysfunction. On the other hand, a higher dosage, 100 mg/kg/d, did not have any effects on the immobility time compared with the vehicle control. Repeated administration of genistein at 10 mg/kg of body weight did not affect serotonergic activities in the hippocampus compared to the vehicle control in ovariectomized rats. A 5-min FST trial stimulated these activities. On the other hand, repeated pretreatment with genistein protected against changes in activity during the FST trial. These results suggest that daily consumption of genistein 10 mg/kg/d might have antidepressant-like effect on ovariectomized rats by regulating changes in serotonergic metabolism in the hippocampus under stressful conditions. |
| doi_str_mv | 10.1271/bbb.100238 |
| format | Article |
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In the present study, we evaluated the antidepressant-like effects of a major isoflavonoid, genistein (4′,5,7-trihydroxyisoflavone), using a behavioral model of depression, the forced swimming test (FST), in ovariectomized rats. Daily administration of genistein to ovariectomized rats at a dosage of 10 mg/kg of body weight/d for 14 d significantly reduced the immobility time during the FST without changing motor dysfunction. On the other hand, a higher dosage, 100 mg/kg/d, did not have any effects on the immobility time compared with the vehicle control. Repeated administration of genistein at 10 mg/kg of body weight did not affect serotonergic activities in the hippocampus compared to the vehicle control in ovariectomized rats. A 5-min FST trial stimulated these activities. On the other hand, repeated pretreatment with genistein protected against changes in activity during the FST trial. These results suggest that daily consumption of genistein 10 mg/kg/d might have antidepressant-like effect on ovariectomized rats by regulating changes in serotonergic metabolism in the hippocampus under stressful conditions.</description><identifier>ISSN: 0916-8451</identifier><identifier>ISSN: 1347-6947</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.100238</identifier><identifier>PMID: 20944428</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Administration, Oral ; Animals ; Antidepressive Agents - administration & dosage ; Antidepressive Agents - pharmacology ; Biological and medical sciences ; Corticosterone - blood ; depressant ; Dopamine - metabolism ; Female ; forced swimming test ; Fundamental and applied biological sciences. Psychology ; genistein ; Genistein - administration & dosage ; Genistein - pharmacology ; Hippocampus - drug effects ; Hippocampus - metabolism ; monoamine ; ovariectomized rat ; Ovariectomy ; Rats ; Rats, Wistar ; Serotonin - metabolism ; Swimming</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2010, Vol.74 (10), p.2005-2010</ispartof><rights>2010 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c675t-759174e51c588c94241d3efc8d894ceed0648d03a786363297d87499c00c34603</citedby><cites>FETCH-LOGICAL-c675t-759174e51c588c94241d3efc8d894ceed0648d03a786363297d87499c00c34603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23710424$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20944428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAGEYAMA, Aya</creatorcontrib><creatorcontrib>SAKAKIBARA, Hiroyuki</creatorcontrib><creatorcontrib>ZHOU, Wenjun</creatorcontrib><creatorcontrib>YOSHIOKA, Miyuki</creatorcontrib><creatorcontrib>OHSUMI, Miho</creatorcontrib><creatorcontrib>SHIMOI, Kayoko</creatorcontrib><creatorcontrib>YOKOGOSHI, Hidehiko</creatorcontrib><title>Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The mortality of individuals suffering from depression has been increasing, especially post-menopausal women; therefore, their care and treatment are important to maintain a high quality of life. In the present study, we evaluated the antidepressant-like effects of a major isoflavonoid, genistein (4′,5,7-trihydroxyisoflavone), using a behavioral model of depression, the forced swimming test (FST), in ovariectomized rats. Daily administration of genistein to ovariectomized rats at a dosage of 10 mg/kg of body weight/d for 14 d significantly reduced the immobility time during the FST without changing motor dysfunction. On the other hand, a higher dosage, 100 mg/kg/d, did not have any effects on the immobility time compared with the vehicle control. Repeated administration of genistein at 10 mg/kg of body weight did not affect serotonergic activities in the hippocampus compared to the vehicle control in ovariectomized rats. A 5-min FST trial stimulated these activities. On the other hand, repeated pretreatment with genistein protected against changes in activity during the FST trial. These results suggest that daily consumption of genistein 10 mg/kg/d might have antidepressant-like effect on ovariectomized rats by regulating changes in serotonergic metabolism in the hippocampus under stressful conditions.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antidepressive Agents - administration & dosage</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Corticosterone - blood</subject><subject>depressant</subject><subject>Dopamine - metabolism</subject><subject>Female</subject><subject>forced swimming test</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genistein</subject><subject>Genistein - administration & dosage</subject><subject>Genistein - pharmacology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>monoamine</subject><subject>ovariectomized rat</subject><subject>Ovariectomy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serotonin - metabolism</subject><subject>Swimming</subject><issn>0916-8451</issn><issn>1347-6947</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0d9rFDEQB_Agij2rL_4BEpAiCFuTzWx-PJZiW6FQaPV5yWVnz5TdzZpkW86_3hx3VRDBp0D4zEwmX0LecnbKa8U_rdfrU85YLfQzsuICVCUNqOdkxQyXlYaGH5FXKd0zVi4a_pIc1cwAQK1XZL7EyaeMfqK3uFkGm7GjdxhDDhPGjXf0zGX_4POWFpK_I73y8xycHecl0dDTmwcbPbocRv-zlN7anOgydRjpRYhu1-zRj6OfNvQuR0zpNXnR2yHhm8N5TL5dfP56flVd31x-OT-7rpxUTa5UY7gCbLhrtHYGauCdwN7pThtwiB2ToDsmrNJSSFEb1WkFxjjGnADJxDH5sO87x_BjwZTb0SeHw2AnDEtqdcNBlhnmv1LJGhSvGRT5_i95H5Y4lTVaDmA0CK13kz_ulYshpYh9O0c_2rhtOWt3gbUlsHYfWMHvDi2X9Yjdb_qUUAEnB2CTs0Mf7eR8-uOE4qz8TnHN3vmpD3G0jyEOXZvtdgjxqUj84wG_AAv1rso</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>KAGEYAMA, Aya</creator><creator>SAKAKIBARA, Hiroyuki</creator><creator>ZHOU, Wenjun</creator><creator>YOSHIOKA, Miyuki</creator><creator>OHSUMI, Miho</creator><creator>SHIMOI, Kayoko</creator><creator>YOKOGOSHI, Hidehiko</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2010</creationdate><title>Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress</title><author>KAGEYAMA, Aya ; SAKAKIBARA, Hiroyuki ; ZHOU, Wenjun ; YOSHIOKA, Miyuki ; OHSUMI, Miho ; SHIMOI, Kayoko ; YOKOGOSHI, Hidehiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c675t-759174e51c588c94241d3efc8d894ceed0648d03a786363297d87499c00c34603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Antidepressive Agents - administration & dosage</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Corticosterone - blood</topic><topic>depressant</topic><topic>Dopamine - metabolism</topic><topic>Female</topic><topic>forced swimming test</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genistein</topic><topic>Genistein - administration & dosage</topic><topic>Genistein - pharmacology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>monoamine</topic><topic>ovariectomized rat</topic><topic>Ovariectomy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Serotonin - metabolism</topic><topic>Swimming</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAGEYAMA, Aya</creatorcontrib><creatorcontrib>SAKAKIBARA, Hiroyuki</creatorcontrib><creatorcontrib>ZHOU, Wenjun</creatorcontrib><creatorcontrib>YOSHIOKA, Miyuki</creatorcontrib><creatorcontrib>OHSUMI, Miho</creatorcontrib><creatorcontrib>SHIMOI, Kayoko</creatorcontrib><creatorcontrib>YOKOGOSHI, Hidehiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAGEYAMA, Aya</au><au>SAKAKIBARA, Hiroyuki</au><au>ZHOU, Wenjun</au><au>YOSHIOKA, Miyuki</au><au>OHSUMI, Miho</au><au>SHIMOI, Kayoko</au><au>YOKOGOSHI, Hidehiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2010</date><risdate>2010</risdate><volume>74</volume><issue>10</issue><spage>2005</spage><epage>2010</epage><pages>2005-2010</pages><issn>0916-8451</issn><issn>1347-6947</issn><eissn>1347-6947</eissn><abstract>The mortality of individuals suffering from depression has been increasing, especially post-menopausal women; therefore, their care and treatment are important to maintain a high quality of life. In the present study, we evaluated the antidepressant-like effects of a major isoflavonoid, genistein (4′,5,7-trihydroxyisoflavone), using a behavioral model of depression, the forced swimming test (FST), in ovariectomized rats. Daily administration of genistein to ovariectomized rats at a dosage of 10 mg/kg of body weight/d for 14 d significantly reduced the immobility time during the FST without changing motor dysfunction. On the other hand, a higher dosage, 100 mg/kg/d, did not have any effects on the immobility time compared with the vehicle control. Repeated administration of genistein at 10 mg/kg of body weight did not affect serotonergic activities in the hippocampus compared to the vehicle control in ovariectomized rats. A 5-min FST trial stimulated these activities. On the other hand, repeated pretreatment with genistein protected against changes in activity during the FST trial. These results suggest that daily consumption of genistein 10 mg/kg/d might have antidepressant-like effect on ovariectomized rats by regulating changes in serotonergic metabolism in the hippocampus under stressful conditions.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>20944428</pmid><doi>10.1271/bbb.100238</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Administration, Oral Animals Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Biological and medical sciences Corticosterone - blood depressant Dopamine - metabolism Female forced swimming test Fundamental and applied biological sciences. Psychology genistein Genistein - administration & dosage Genistein - pharmacology Hippocampus - drug effects Hippocampus - metabolism monoamine ovariectomized rat Ovariectomy Rats Rats, Wistar Serotonin - metabolism Swimming |
| title | Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress |
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