Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer
Purpose: To test whether the intrinsic radiosensitivity of skin fibroblasts from breast cancer patients correlates with the degree of breast fibrosis after breast conserving therapy. Methods: In a systematic study design, 79 patients were selected from an earlier study group of 385 patients based on...
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| Veröffentlicht in: | International journal of radiation biology 1998, Vol.73 (6), p.661-670 |
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| container_title | International journal of radiation biology |
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| creator | RUSSELL, N.S GRUMMELS, A HART, A.A.M SMOLDERS, I.J.H BORGER, J BARTELINK, H BEGG, A. C. |
| description | Purpose: To test whether the intrinsic radiosensitivity of skin fibroblasts from breast cancer patients correlates with the degree of breast fibrosis after breast conserving therapy. Methods: In a systematic study design, 79 patients were selected from an earlier study group of 385 patients based on observed fibrosis and seven identified clinical risk factors for fibrosis development. In vitro radiosensitivity of patients' dermal fibroblasts was determined by clonogenic assay of early passage cultures. Survival was determined after irradiation at 0, 2 and 4 Gy, given in two fractions of 2 Gy with a 6 h interval. Results: There was a significant inter-patient variation for SF2 values (coefficient of variation 40%). The ratio of SF2 values for fibroblasts from patients with breast fibrosis versus those without was 0.80 (95% CI: 0.60-1.07). This was a statistically non-significant trend (p 0.13). The same ratio for a derived value for SF2 ((SF2 SF4)/2) was 0.88 (p 0.19). Conclusions: A significant variation in intrinsic radiosensitivity of breast cancer patients' dermal fibroblasts was observed. However, the degree of radiosensitivity did not show a significant correlation with fibrosis development. This indicates that the use of fibroblast radiosensitivity will have a limited usefulness for predicting fibrosis following breast irradiation. |
| doi_str_mv | 10.1080/095530098141915 |
| format | Article |
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C.</creator><creatorcontrib>RUSSELL, N.S ; GRUMMELS, A ; HART, A.A.M ; SMOLDERS, I.J.H ; BORGER, J ; BARTELINK, H ; BEGG, A. C.</creatorcontrib><description>Purpose: To test whether the intrinsic radiosensitivity of skin fibroblasts from breast cancer patients correlates with the degree of breast fibrosis after breast conserving therapy. Methods: In a systematic study design, 79 patients were selected from an earlier study group of 385 patients based on observed fibrosis and seven identified clinical risk factors for fibrosis development. In vitro radiosensitivity of patients' dermal fibroblasts was determined by clonogenic assay of early passage cultures. Survival was determined after irradiation at 0, 2 and 4 Gy, given in two fractions of 2 Gy with a 6 h interval. Results: There was a significant inter-patient variation for SF2 values (coefficient of variation 40%). The ratio of SF2 values for fibroblasts from patients with breast fibrosis versus those without was 0.80 (95% CI: 0.60-1.07). This was a statistically non-significant trend (p 0.13). The same ratio for a derived value for SF2 ((SF2 SF4)/2) was 0.88 (p 0.19). Conclusions: A significant variation in intrinsic radiosensitivity of breast cancer patients' dermal fibroblasts was observed. However, the degree of radiosensitivity did not show a significant correlation with fibrosis development. This indicates that the use of fibroblast radiosensitivity will have a limited usefulness for predicting fibrosis following breast irradiation.</description><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/095530098141915</identifier><identifier>PMID: 9690684</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Age Factors ; Analysis of Variance ; Biological and medical sciences ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Breast Neoplasms - radiotherapy ; Cell Survival - radiation effects ; Cells, Cultured ; Chemotherapy, Adjuvant ; Cobalt Radioisotopes ; Female ; Fibroblasts - pathology ; Fibroblasts - radiation effects ; Fibrosis ; Follow-Up Studies ; Gamma Rays ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Predictive Value of Tests ; Radiotherapy - adverse effects ; Radiotherapy Dosage ; Reproducibility of Results ; Retrospective Studies ; Risk Factors ; Skin - pathology ; Skin - radiation effects ; Time Factors ; Tumors</subject><ispartof>International journal of radiation biology, 1998, Vol.73 (6), p.661-670</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-f02153d90718ef6a64dc4e8218effdc5e919d47e7b338005fc0f0088c04a40bc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/095530098141915$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/095530098141915$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2338885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9690684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RUSSELL, N.S</creatorcontrib><creatorcontrib>GRUMMELS, A</creatorcontrib><creatorcontrib>HART, A.A.M</creatorcontrib><creatorcontrib>SMOLDERS, I.J.H</creatorcontrib><creatorcontrib>BORGER, J</creatorcontrib><creatorcontrib>BARTELINK, H</creatorcontrib><creatorcontrib>BEGG, A. C.</creatorcontrib><title>Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol</addtitle><description>Purpose: To test whether the intrinsic radiosensitivity of skin fibroblasts from breast cancer patients correlates with the degree of breast fibrosis after breast conserving therapy. Methods: In a systematic study design, 79 patients were selected from an earlier study group of 385 patients based on observed fibrosis and seven identified clinical risk factors for fibrosis development. In vitro radiosensitivity of patients' dermal fibroblasts was determined by clonogenic assay of early passage cultures. Survival was determined after irradiation at 0, 2 and 4 Gy, given in two fractions of 2 Gy with a 6 h interval. Results: There was a significant inter-patient variation for SF2 values (coefficient of variation 40%). The ratio of SF2 values for fibroblasts from patients with breast fibrosis versus those without was 0.80 (95% CI: 0.60-1.07). This was a statistically non-significant trend (p 0.13). The same ratio for a derived value for SF2 ((SF2 SF4)/2) was 0.88 (p 0.19). Conclusions: A significant variation in intrinsic radiosensitivity of breast cancer patients' dermal fibroblasts was observed. However, the degree of radiosensitivity did not show a significant correlation with fibrosis development. This indicates that the use of fibroblast radiosensitivity will have a limited usefulness for predicting fibrosis following breast irradiation.</description><subject>Age Factors</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Cell Survival - radiation effects</subject><subject>Cells, Cultured</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cobalt Radioisotopes</subject><subject>Female</subject><subject>Fibroblasts - pathology</subject><subject>Fibroblasts - radiation effects</subject><subject>Fibrosis</subject><subject>Follow-Up Studies</subject><subject>Gamma Rays</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Predictive Value of Tests</subject><subject>Radiotherapy - adverse effects</subject><subject>Radiotherapy Dosage</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Skin - pathology</subject><subject>Skin - radiation effects</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UM-L1DAUDqKs4-rZk9CDeBv3pUk7iTdZ1h8w4EXPJU1enCxpU5N0hjn5r5vScUFhT3l53w--9xHymsJ7CgJuQDYNA5CCcipp84RsKGvrLSv7p2SzoGWG-jl5kdI9lAmYuCJXspXQCr4hv_fhVE0RjdPZHbE6Kj9jFWzlxhzdmJyurOtj6L1KuYrKuJCwrAvZ5XNlQ1zx5FJl8Ig-TAOOuQDeh5Mbf66afMCoppXfR1y8tBo1xpfkmVU-4avLe01-fLr7fvtlu__2-evtx_1WN1TmrYWaNsxI2FGBtlUtN5qjqJefNbpBSaXhO9z1jAmAxmqwAEJo4IpDr9k1ebf6TjH8mjHlbnBJo_dqxDCnjrZccs7rQrxZiboclSLabopuUPHcUeiWyrv_Ki-KNxfruR_QPPAvHRf87QVXSStvYzncpQdaXRILsdh8WGluLC0N6hSiN11WZx_iXw17PIP8R3xA5fNBq4jdfZjjWKp9NP8fpSuwcQ</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>RUSSELL, N.S</creator><creator>GRUMMELS, A</creator><creator>HART, A.A.M</creator><creator>SMOLDERS, I.J.H</creator><creator>BORGER, J</creator><creator>BARTELINK, H</creator><creator>BEGG, A. C.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1998</creationdate><title>Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer</title><author>RUSSELL, N.S ; GRUMMELS, A ; HART, A.A.M ; SMOLDERS, I.J.H ; BORGER, J ; BARTELINK, H ; BEGG, A. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-f02153d90718ef6a64dc4e8218effdc5e919d47e7b338005fc0f0088c04a40bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Age Factors</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>Cell Survival - radiation effects</topic><topic>Cells, Cultured</topic><topic>Chemotherapy, Adjuvant</topic><topic>Cobalt Radioisotopes</topic><topic>Female</topic><topic>Fibroblasts - pathology</topic><topic>Fibroblasts - radiation effects</topic><topic>Fibrosis</topic><topic>Follow-Up Studies</topic><topic>Gamma Rays</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Predictive Value of Tests</topic><topic>Radiotherapy - adverse effects</topic><topic>Radiotherapy Dosage</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Skin - pathology</topic><topic>Skin - radiation effects</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RUSSELL, N.S</creatorcontrib><creatorcontrib>GRUMMELS, A</creatorcontrib><creatorcontrib>HART, A.A.M</creatorcontrib><creatorcontrib>SMOLDERS, I.J.H</creatorcontrib><creatorcontrib>BORGER, J</creatorcontrib><creatorcontrib>BARTELINK, H</creatorcontrib><creatorcontrib>BEGG, A. C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RUSSELL, N.S</au><au>GRUMMELS, A</au><au>HART, A.A.M</au><au>SMOLDERS, I.J.H</au><au>BORGER, J</au><au>BARTELINK, H</au><au>BEGG, A. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1998</date><risdate>1998</risdate><volume>73</volume><issue>6</issue><spage>661</spage><epage>670</epage><pages>661-670</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>Purpose: To test whether the intrinsic radiosensitivity of skin fibroblasts from breast cancer patients correlates with the degree of breast fibrosis after breast conserving therapy. Methods: In a systematic study design, 79 patients were selected from an earlier study group of 385 patients based on observed fibrosis and seven identified clinical risk factors for fibrosis development. In vitro radiosensitivity of patients' dermal fibroblasts was determined by clonogenic assay of early passage cultures. Survival was determined after irradiation at 0, 2 and 4 Gy, given in two fractions of 2 Gy with a 6 h interval. Results: There was a significant inter-patient variation for SF2 values (coefficient of variation 40%). The ratio of SF2 values for fibroblasts from patients with breast fibrosis versus those without was 0.80 (95% CI: 0.60-1.07). This was a statistically non-significant trend (p 0.13). The same ratio for a derived value for SF2 ((SF2 SF4)/2) was 0.88 (p 0.19). Conclusions: A significant variation in intrinsic radiosensitivity of breast cancer patients' dermal fibroblasts was observed. However, the degree of radiosensitivity did not show a significant correlation with fibrosis development. This indicates that the use of fibroblast radiosensitivity will have a limited usefulness for predicting fibrosis following breast irradiation.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>9690684</pmid><doi>10.1080/095530098141915</doi><tpages>10</tpages></addata></record> |
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| ispartof | International journal of radiation biology, 1998, Vol.73 (6), p.661-670 |
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| subjects | Age Factors Analysis of Variance Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Cell Survival - radiation effects Cells, Cultured Chemotherapy, Adjuvant Cobalt Radioisotopes Female Fibroblasts - pathology Fibroblasts - radiation effects Fibrosis Follow-Up Studies Gamma Rays Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Predictive Value of Tests Radiotherapy - adverse effects Radiotherapy Dosage Reproducibility of Results Retrospective Studies Risk Factors Skin - pathology Skin - radiation effects Time Factors Tumors |
| title | Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer |
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