Combination Chemotherapy with G-CSF, M-CSF and EPO: Successful Treatment for Acute Myelogenous Leukemia without Blood Transfusion at Lower Medical Costs
A 55-year-old Jehova’s Witness was treated for acute myelogenous leukemia (AML) by intensive chemotherapy with enocitabine, 6-mercaptopurine and daunorubicin. G-CSF, M-CSF and EPO were subsequently administered. Even though no blood transfusion was given for religious reasons, complete remission was...
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| Veröffentlicht in: | Acta haematologica 1998-01, Vol.100 (1), p.57-60 |
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| container_title | Acta haematologica |
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| creator | Kaito, K. Kobayashi, M. Sakamoto, M. Shimada, T. Masuoka, H. Nishiwaki, K. Saeki, A. Sekita, T. Otsubo, H. Hosoya, T. |
| description | A 55-year-old Jehova’s Witness was treated for acute myelogenous leukemia (AML) by intensive chemotherapy with enocitabine, 6-mercaptopurine and daunorubicin. G-CSF, M-CSF and EPO were subsequently administered. Even though no blood transfusion was given for religious reasons, complete remission was achieved without serious infection and hemorrhage. The total cost for induction chemotherapy was less expensive than is the case for elderly AML patients. This case indicates that the administration of cytokines might reduce the incidence of infection and the necessity for blood products, which would result in favorable cost effectiveness for the treatment of elderly patients with AML. |
| doi_str_mv | 10.1159/000040865 |
| format | Article |
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G-CSF, M-CSF and EPO were subsequently administered. Even though no blood transfusion was given for religious reasons, complete remission was achieved without serious infection and hemorrhage. The total cost for induction chemotherapy was less expensive than is the case for elderly AML patients. This case indicates that the administration of cytokines might reduce the incidence of infection and the necessity for blood products, which would result in favorable cost effectiveness for the treatment of elderly patients with AML.</description><identifier>ISSN: 0001-5792</identifier><identifier>EISSN: 1421-9662</identifier><identifier>DOI: 10.1159/000040865</identifier><identifier>PMID: 9691149</identifier><identifier>CODEN: ACHAAH</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Blood Transfusion ; Case Report ; Costs and Cost Analysis ; Drug toxicity and drugs side effects treatment ; Erythropoietin - therapeutic use ; Granulocyte Colony-Stimulating Factor - therapeutic use ; Humans ; Leukemia, Myeloid, Acute - drug therapy ; Leukemia, Myeloid, Acute - economics ; Macrophage Colony-Stimulating Factor - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Pharmacology. 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Karger AG, Basel</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-3cca71a65cb79941e0574b18398a22cb361fac2bcbf6dccdee2af7075542ca9c3</citedby><cites>FETCH-LOGICAL-c356t-3cca71a65cb79941e0574b18398a22cb361fac2bcbf6dccdee2af7075542ca9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2336842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9691149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaito, K.</creatorcontrib><creatorcontrib>Kobayashi, M.</creatorcontrib><creatorcontrib>Sakamoto, M.</creatorcontrib><creatorcontrib>Shimada, T.</creatorcontrib><creatorcontrib>Masuoka, H.</creatorcontrib><creatorcontrib>Nishiwaki, K.</creatorcontrib><creatorcontrib>Saeki, A.</creatorcontrib><creatorcontrib>Sekita, T.</creatorcontrib><creatorcontrib>Otsubo, H.</creatorcontrib><creatorcontrib>Hosoya, T.</creatorcontrib><title>Combination Chemotherapy with G-CSF, M-CSF and EPO: Successful Treatment for Acute Myelogenous Leukemia without Blood Transfusion at Lower Medical Costs</title><title>Acta haematologica</title><addtitle>Acta Haematol</addtitle><description>A 55-year-old Jehova’s Witness was treated for acute myelogenous leukemia (AML) by intensive chemotherapy with enocitabine, 6-mercaptopurine and daunorubicin. G-CSF, M-CSF and EPO were subsequently administered. Even though no blood transfusion was given for religious reasons, complete remission was achieved without serious infection and hemorrhage. The total cost for induction chemotherapy was less expensive than is the case for elderly AML patients. This case indicates that the administration of cytokines might reduce the incidence of infection and the necessity for blood products, which would result in favorable cost effectiveness for the treatment of elderly patients with AML.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion</subject><subject>Case Report</subject><subject>Costs and Cost Analysis</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Erythropoietin - therapeutic use</subject><subject>Granulocyte Colony-Stimulating Factor - therapeutic use</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - drug therapy</subject><subject>Leukemia, Myeloid, Acute - economics</subject><subject>Macrophage Colony-Stimulating Factor - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Remission Induction</topic><topic>Toxicity: blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaito, K.</creatorcontrib><creatorcontrib>Kobayashi, M.</creatorcontrib><creatorcontrib>Sakamoto, M.</creatorcontrib><creatorcontrib>Shimada, T.</creatorcontrib><creatorcontrib>Masuoka, H.</creatorcontrib><creatorcontrib>Nishiwaki, K.</creatorcontrib><creatorcontrib>Saeki, A.</creatorcontrib><creatorcontrib>Sekita, T.</creatorcontrib><creatorcontrib>Otsubo, H.</creatorcontrib><creatorcontrib>Hosoya, T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta haematologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaito, K.</au><au>Kobayashi, M.</au><au>Sakamoto, M.</au><au>Shimada, T.</au><au>Masuoka, H.</au><au>Nishiwaki, K.</au><au>Saeki, A.</au><au>Sekita, T.</au><au>Otsubo, H.</au><au>Hosoya, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination Chemotherapy with G-CSF, M-CSF and EPO: Successful Treatment for Acute Myelogenous Leukemia without Blood Transfusion at Lower Medical Costs</atitle><jtitle>Acta haematologica</jtitle><addtitle>Acta Haematol</addtitle><date>1998-01</date><risdate>1998</risdate><volume>100</volume><issue>1</issue><spage>57</spage><epage>60</epage><pages>57-60</pages><issn>0001-5792</issn><eissn>1421-9662</eissn><coden>ACHAAH</coden><abstract>A 55-year-old Jehova’s Witness was treated for acute myelogenous leukemia (AML) by intensive chemotherapy with enocitabine, 6-mercaptopurine and daunorubicin. G-CSF, M-CSF and EPO were subsequently administered. Even though no blood transfusion was given for religious reasons, complete remission was achieved without serious infection and hemorrhage. The total cost for induction chemotherapy was less expensive than is the case for elderly AML patients. This case indicates that the administration of cytokines might reduce the incidence of infection and the necessity for blood products, which would result in favorable cost effectiveness for the treatment of elderly patients with AML.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>9691149</pmid><doi>10.1159/000040865</doi><tpages>4</tpages></addata></record> |
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| ispartof | Acta haematologica, 1998-01, Vol.100 (1), p.57-60 |
| issn | 0001-5792 1421-9662 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_2336842 |
| source | MEDLINE; Karger Journals Complete |
| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Blood Transfusion Case Report Costs and Cost Analysis Drug toxicity and drugs side effects treatment Erythropoietin - therapeutic use Granulocyte Colony-Stimulating Factor - therapeutic use Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - economics Macrophage Colony-Stimulating Factor - therapeutic use Male Medical sciences Middle Aged Pharmacology. Drug treatments Remission Induction Toxicity: blood |
| title | Combination Chemotherapy with G-CSF, M-CSF and EPO: Successful Treatment for Acute Myelogenous Leukemia without Blood Transfusion at Lower Medical Costs |
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