Isolation of 6-, 8-, and 10-gingerol from ginger rhizome by HPLC and preliminary evaluation of inhibition of Mycobacterium avium and Mycobacterium tuberculosis
Diseases caused by Mycobacterium avium (M. avium) and Mycobacterium tuberculosis (M. tuberculosis) have reached pandemic proportions with some strains being resistant to existing chemotherapies. Complex therapies requiring four to six drugs are sometimes required to prevent the emergence of resistan...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 1998-07, Vol.46 (7), p.2504-2508 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Hiserodt, R.D. (The State University of New Jersey, NB, NJ.) Franzblau, S.G Rosen, R.T |
| description | Diseases caused by Mycobacterium avium (M. avium) and Mycobacterium tuberculosis (M. tuberculosis) have reached pandemic proportions with some strains being resistant to existing chemotherapies. Complex therapies requiring four to six drugs are sometimes required to prevent the emergence of resistant strains. There is a need for the discovery of new drugs or compounds that are potential drug templates that can be used to treat diseases caused by these bacteria. The research reported in this paper describes the isolation of 6-, 8-, and 10-gingerol from fresh ginger rhizome and the identification of 10-gingerol as the most active inhibitor of M. avium and M. tuberculosis in vitro. The gingerols were isolated by fractionation of a crude methylene chloride extract of fresh ginger rhizome by normal phase HPLC. Identification was based on mass spectral data. The identification of 10-gingerol was confirmed by synthesis |
| doi_str_mv | 10.1021/jf970948l |
| format | Article |
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(The State University of New Jersey, NB, NJ.) ; Franzblau, S.G ; Rosen, R.T</creator><creatorcontrib>Hiserodt, R.D. (The State University of New Jersey, NB, NJ.) ; Franzblau, S.G ; Rosen, R.T</creatorcontrib><description>Diseases caused by Mycobacterium avium (M. avium) and Mycobacterium tuberculosis (M. tuberculosis) have reached pandemic proportions with some strains being resistant to existing chemotherapies. Complex therapies requiring four to six drugs are sometimes required to prevent the emergence of resistant strains. There is a need for the discovery of new drugs or compounds that are potential drug templates that can be used to treat diseases caused by these bacteria. The research reported in this paper describes the isolation of 6-, 8-, and 10-gingerol from fresh ginger rhizome and the identification of 10-gingerol as the most active inhibitor of M. avium and M. tuberculosis in vitro. The gingerols were isolated by fractionation of a crude methylene chloride extract of fresh ginger rhizome by normal phase HPLC. Identification was based on mass spectral data. The identification of 10-gingerol was confirmed by synthesis</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf970948l</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>6-GINGEROL ; 8-GINGEROL ; ANTIBACTERIAL PROPERTIES ; ANTIMICROBIAL PROPERTIES ; Biological and medical sciences ; General pharmacology ; GINGEMBRE ; GINGER ; IDENTIFICACION ; IDENTIFICATION ; JENGIBRE ; Medical sciences ; MYCOBACTERIUM AVIUM ; MYCOBACTERIUM TUBERCULOSIS ; PHARMACEUTICAL PRODUCTS ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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(The State University of New Jersey, NB, NJ.)</creatorcontrib><creatorcontrib>Franzblau, S.G</creatorcontrib><creatorcontrib>Rosen, R.T</creatorcontrib><title>Isolation of 6-, 8-, and 10-gingerol from ginger rhizome by HPLC and preliminary evaluation of inhibition of Mycobacterium avium and Mycobacterium tuberculosis</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Diseases caused by Mycobacterium avium (M. avium) and Mycobacterium tuberculosis (M. tuberculosis) have reached pandemic proportions with some strains being resistant to existing chemotherapies. Complex therapies requiring four to six drugs are sometimes required to prevent the emergence of resistant strains. There is a need for the discovery of new drugs or compounds that are potential drug templates that can be used to treat diseases caused by these bacteria. The research reported in this paper describes the isolation of 6-, 8-, and 10-gingerol from fresh ginger rhizome and the identification of 10-gingerol as the most active inhibitor of M. avium and M. tuberculosis in vitro. The gingerols were isolated by fractionation of a crude methylene chloride extract of fresh ginger rhizome by normal phase HPLC. Identification was based on mass spectral data. 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Drug treatments</subject><subject>PROPIEDADES ANTIMICROBIANAS</subject><subject>PROPRIETE ANTIMICROBIENNE</subject><subject>RHIZOME</subject><subject>RHIZOMES</subject><subject>RIZOMAS</subject><subject>ZINGIBER OFFICINALE</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpVj8lOxDAMhiMEEsNy4AGQcuBIwWm25ogGBpCGTSzXKm2TIdA2o6SDGF6GVyViAImDbdn-_l82QnsEjgjk5PjFKgmKFe0aGhGeQ8YJKdbRCNIyK7ggm2grxhcAKLiEEfq8jL7Vg_M99haL7BAXKXTfYALZzPUzE3yLbfAdXnU4PLsP3xlcLfHF7XT8zc6DaV3neh2W2LzpdvHn6PpnV7nf7mpZ-0rXgwlu0WH99p2T_v98WFQm1IvWRxd30IbVbTS7P3UbPU7OHsYX2fTm_HJ8Ms1szmDIqAJJG1MXBWcirzmrNRWiolZawaAxijIFIGwODaeGaUVl1VDQNikUo5Juo4OV71zHWrc26L52sZwH16WnypxSVhCRsGyFuTiY97-1Dq-lkFTy8uH2vryeyFNOrp7Ku8Tvr3irfalnIVk-3hOl0jEgkt8XGbWEBA</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Hiserodt, R.D. 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(The State University of New Jersey, NB, NJ.) ; Franzblau, S.G ; Rosen, R.T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f240t-39073dec885462c54ca366b3f7f640de9349006f20d53e4a937bd30afc8894373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>6-GINGEROL</topic><topic>8-GINGEROL</topic><topic>ANTIBACTERIAL PROPERTIES</topic><topic>ANTIMICROBIAL PROPERTIES</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>GINGEMBRE</topic><topic>GINGER</topic><topic>IDENTIFICACION</topic><topic>IDENTIFICATION</topic><topic>JENGIBRE</topic><topic>Medical sciences</topic><topic>MYCOBACTERIUM AVIUM</topic><topic>MYCOBACTERIUM TUBERCULOSIS</topic><topic>PHARMACEUTICAL PRODUCTS</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. 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(The State University of New Jersey, NB, NJ.)</au><au>Franzblau, S.G</au><au>Rosen, R.T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation of 6-, 8-, and 10-gingerol from ginger rhizome by HPLC and preliminary evaluation of inhibition of Mycobacterium avium and Mycobacterium tuberculosis</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>46</volume><issue>7</issue><spage>2504</spage><epage>2508</epage><pages>2504-2508</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Diseases caused by Mycobacterium avium (M. avium) and Mycobacterium tuberculosis (M. tuberculosis) have reached pandemic proportions with some strains being resistant to existing chemotherapies. Complex therapies requiring four to six drugs are sometimes required to prevent the emergence of resistant strains. There is a need for the discovery of new drugs or compounds that are potential drug templates that can be used to treat diseases caused by these bacteria. The research reported in this paper describes the isolation of 6-, 8-, and 10-gingerol from fresh ginger rhizome and the identification of 10-gingerol as the most active inhibitor of M. avium and M. tuberculosis in vitro. The gingerols were isolated by fractionation of a crude methylene chloride extract of fresh ginger rhizome by normal phase HPLC. Identification was based on mass spectral data. The identification of 10-gingerol was confirmed by synthesis</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><doi>10.1021/jf970948l</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8561 |
| ispartof | Journal of agricultural and food chemistry, 1998-07, Vol.46 (7), p.2504-2508 |
| issn | 0021-8561 1520-5118 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_2334816 |
| source | ACS Publications |
| subjects | 6-GINGEROL 8-GINGEROL ANTIBACTERIAL PROPERTIES ANTIMICROBIAL PROPERTIES Biological and medical sciences General pharmacology GINGEMBRE GINGER IDENTIFICACION IDENTIFICATION JENGIBRE Medical sciences MYCOBACTERIUM AVIUM MYCOBACTERIUM TUBERCULOSIS PHARMACEUTICAL PRODUCTS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PROPIEDADES ANTIMICROBIANAS PROPRIETE ANTIMICROBIENNE RHIZOME RHIZOMES RIZOMAS ZINGIBER OFFICINALE |
| title | Isolation of 6-, 8-, and 10-gingerol from ginger rhizome by HPLC and preliminary evaluation of inhibition of Mycobacterium avium and Mycobacterium tuberculosis |
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