Furan Approach to Vitamin D Analogues. Synthesis of the A-Ring of Calcitriol and 1α-Hydroxy-3-deoxyvitamin D3

The A-rings of calcitriol (1α,25-dihydroxyvitamin D3) and 1α-hydroxy-3-deoxyvitamin D3 were synthesized using the furan approach. The critical steps in the synthesis of the A-ring of calcitriol involved an asymmetric carbonyl-ene reaction of 3-methylene-2,3-dihydrofuran with 3-(tert-butyldimethylsil...

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Veröffentlicht in:	Journal of organic chemistry 2010-10, Vol.75 (20), p.6820-6829
Hauptverfasser:	Miles, William H, Connell, Katelyn B, Ulas, Gözde, Tuson, Hannah H, Dethoff, Elizabeth A, Mehta, Varun, Thrall, April J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Organic chemistry Preparations and properties Steroids
Online-Zugang:	Volltext
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