Pharmacological characterization of an epibatidine binding site in the nerve cord of Periplaneta americana

A binding site for [3H](+/-)-epibatidine was found to be present in American cockroach nerve cord homogenates. This binding site was saturable, with a Kd of 6.4 +/- 0.8 nM and a Bmax of 3.4 +/- 1.1 pmol/mg protein. The pharmacology of this site suggests it to be associated with the nicotinic acetylc...

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Veröffentlicht in:	Pesticide biochemistry and physiology 1997, Vol.58 (3), p.183-192
Hauptverfasser:	Orr, N, Shaffner, A.J, Watson, G.B
Format:	Artikel
Sprache:	eng
Schlagworte:	ALCALOIDE ALCALOIDES ALKALOIDS Analgesics Biochemistry. Physiology. Immunology Biological and medical sciences Chemical control CHOLINERGIC RECEPTORS Control ELECTROPHYSIOLOGY Fundamental and applied biological sciences. Psychology Insecta Invertebrates ISOMERS Medical sciences Medically important nuisances and vectors, pests of stored products and materials: population survey and control NERF NERVES NERVIOS Neuropharmacology Nuisances PERIPHERAL NERVES PERIPLANETA AMERICANA Pharmacology. Drug treatments Physiology. Development Phytopathology. Animal pests. Plant and forest protection Protozoa. Invertebrates
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