Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity

This study examined the effect of acetate on endothelial nitric oxide synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) by immunoblotting assay and the ability of acetic acid to upregulate flow-mediated vasodilatation in humans. In HUVECs, acetate induced a biphasic increase in the...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (5), p.1055-1061
Hauptverfasser:	Sakakibara, S., Mizkan Group Corp., Handa, Aichi (Japan), Murakami, R, Takahashi, M, Fushimi, T, Murohara, T, Kishi, M, Kajimoto, Y, Kitakaze, M, Kaga, T
Format:	Artikel
Sprache:	eng
Schlagworte:	ACETIC ACID Acetic Acid - metabolism Acetic Acid - pharmacology ACIDE ACETIQUE ACIDO ACETICO ADMINISTRACION ADMINISTRATION AMP-activated protein kinase (AMPK) AMP-Activated Protein Kinases - metabolism Biological and medical sciences Biological Transport BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS CARDIOVASCULAR AGENTS Cell Line Endothelial Cells - drug effects Endothelial Cells - metabolism endothelial function endothelial nitric oxide synthase (eNOS) phosphorylation ENZIMAS ENZYME Enzyme Activation - drug effects ENZYMES Female FOSFORILACION Fundamental and applied biological sciences. Psychology http://www.fao.org/aos/agrovoc#c_130 http://www.fao.org/aos/agrovoc#c_1316 http://www.fao.org/aos/agrovoc#c_2603 http://www.fao.org/aos/agrovoc#c_36996 http://www.fao.org/aos/agrovoc#c_37466 http://www.fao.org/aos/agrovoc#c_5806 http://www.fao.org/aos/agrovoc#c_7865 http://www.fao.org/aos/agrovoc#c_80 http://www.fao.org/aos/agrovoc#c_8253 http://www.fao.org/aos/agrovoc#c_928 Humans MECANISMOS DE ACCION MEDICAMENTOS CARDIOVASCULARES Middle Aged MODE D'ACTION MODE OF ACTION MODIFICATEUR CARDIOVASCULAIRE NITRIC OXIDE Nitric Oxide Synthase Type III - metabolism OXIDO NITRICO OXYDE NITRIQUE PHOSPHORYLATION Phosphorylation - drug effects PKA Plethysmography Protein Kinase Inhibitors - pharmacology Regional Blood Flow Signal Transduction - drug effects TRANSFERASAS TRANSFERASE TRANSFERASES Up-Regulation - drug effects Vasodilation - drug effects VINAGRE VINAIGRE VINEGAR
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