Autonomous Effects of Shear Stress and Cyclic Circumferential Stretch regarding Endothelial Dysfunction and Oxidative Stress: An ex vivo Arterial Model

Cyclic circumferential stretch and shear stress caused by pulsatile blood flow work in concert, yet are very different stimuli capable of independently mediating endothelial function by modulating eNOS expression, oxidative stress (via production of superoxide anion) and NO bioavailability. Porcine...

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Veröffentlicht in:	Journal of vascular research 2010-01, Vol.47 (4), p.336-345
Hauptverfasser:	Thacher, Tyler N., Silacci, Paolo, Stergiopulos, Nikos, da Silva, Rafaela F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bradykinin - pharmacology Carotid Artery, Internal - drug effects Carotid Artery, Internal - metabolism Carotid Artery, Internal - physiopathology Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Fundamental and applied biological sciences. Psychology In Vitro Techniques Mechanotransduction, Cellular Models, Animal NADPH Oxidases - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Nitroprusside - pharmacology Oxidative Stress Perfusion Pulsatile Flow Research Paper Stress, Mechanical Superoxides - metabolism Swine Tyrosine - analogs & derivatives Tyrosine - metabolism Vasodilation - drug effects Vasodilator Agents - pharmacology Vertebrates: cardiovascular system
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