Comparison of the effects on lipid metabolism of dietary methionine and cystine between hepatoma-bearing and normal rats
The effects of dietary supplementation with methionine and cystine on lipid metabolism, including the serum lipid concentration, were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line (AH109A) for comparison with normal rats. A diet supplemented with 1.2% L-methionin...
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| creator | Kawasaki, M., Tokyo Univ. of Agriculture and Technology, Fuchu (Japan) Miura, Y Funabiki, R Yagasaki, K |
| description | The effects of dietary supplementation with methionine and cystine on lipid metabolism, including the serum lipid concentration, were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line (AH109A) for comparison with normal rats. A diet supplemented with 1.2% L-methionine or L-cystine to 20% casein was found to suppress the hepatoma-induced increases in serum triglyceride and total cholesterol concentration. The lipoprotein lipase activity in tissues was enhanced by dietary methionine and cystine, with no change in the mRNA level. Dietary methionine and cystine increased bile acid excretion into the feces with enhanced hepatic cholesterol 7α-hydroxylase activity. Dietary methionine and cystine affected the lipid metabolism differently in normal rats from hepatoma-bearing rats. These results suggest that dietary methionine and cystine each had a hypolipidemic effect against cancer-induced hyperlipidemia, and that the different actions observed in the hepatoma-bearing and normal rats may have been due to a metabolic abnormality caused by the cancer. |
| doi_str_mv | 10.1271/bbb.90673 |
| format | Article |
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A diet supplemented with 1.2% L-methionine or L-cystine to 20% casein was found to suppress the hepatoma-induced increases in serum triglyceride and total cholesterol concentration. The lipoprotein lipase activity in tissues was enhanced by dietary methionine and cystine, with no change in the mRNA level. Dietary methionine and cystine increased bile acid excretion into the feces with enhanced hepatic cholesterol 7α-hydroxylase activity. Dietary methionine and cystine affected the lipid metabolism differently in normal rats from hepatoma-bearing rats. These results suggest that dietary methionine and cystine each had a hypolipidemic effect against cancer-induced hyperlipidemia, and that the different actions observed in the hepatoma-bearing and normal rats may have been due to a metabolic abnormality caused by the cancer.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.90673</identifier><identifier>PMID: 20057121</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Animals ; Biological and medical sciences ; Body Weight - drug effects ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - physiopathology ; CISTINA ; CYSTINE ; Cystine - pharmacology ; Diet ; Eating - drug effects ; Fundamental and applied biological sciences. Psychology ; hepatoma ; http://www.fao.org/aos/agrovoc#c_2086 ; http://www.fao.org/aos/agrovoc#c_4361 ; http://www.fao.org/aos/agrovoc#c_4787 ; http://www.fao.org/aos/agrovoc#c_5122 ; http://www.fao.org/aos/agrovoc#c_6464 ; hyperlipidemia ; Hypolipidemic Agents - pharmacology ; LIPID METABOLISM ; Lipid Metabolism - drug effects ; Lipids - blood ; Lipolysis - drug effects ; Liver Neoplasms - blood ; Liver Neoplasms - metabolism ; Liver Neoplasms - physiopathology ; Male ; METABOLISME DES LIPIDES ; METABOLISMO DE LIPIDOS ; METHIONINE ; Methionine - pharmacology ; METIONINA ; NEOPLASMAS ; NEOPLASME ; NEOPLASMS ; RAT ; RATA ; RATS</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2010-01, Vol.74 (1), p.158-167</ispartof><rights>2010 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c724t-a6c32c11ba882e3837d5902b500064e154ba6186f51367be608b3e25fa3553593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22694647$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20057121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawasaki, M., Tokyo Univ. of Agriculture and Technology, Fuchu (Japan)</creatorcontrib><creatorcontrib>Miura, Y</creatorcontrib><creatorcontrib>Funabiki, R</creatorcontrib><creatorcontrib>Yagasaki, K</creatorcontrib><title>Comparison of the effects on lipid metabolism of dietary methionine and cystine between hepatoma-bearing and normal rats</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The effects of dietary supplementation with methionine and cystine on lipid metabolism, including the serum lipid concentration, were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line (AH109A) for comparison with normal rats. A diet supplemented with 1.2% L-methionine or L-cystine to 20% casein was found to suppress the hepatoma-induced increases in serum triglyceride and total cholesterol concentration. The lipoprotein lipase activity in tissues was enhanced by dietary methionine and cystine, with no change in the mRNA level. Dietary methionine and cystine increased bile acid excretion into the feces with enhanced hepatic cholesterol 7α-hydroxylase activity. Dietary methionine and cystine affected the lipid metabolism differently in normal rats from hepatoma-bearing rats. These results suggest that dietary methionine and cystine each had a hypolipidemic effect against cancer-induced hyperlipidemia, and that the different actions observed in the hepatoma-bearing and normal rats may have been due to a metabolic abnormality caused by the cancer.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - physiopathology</subject><subject>CISTINA</subject><subject>CYSTINE</subject><subject>Cystine - pharmacology</subject><subject>Diet</subject><subject>Eating - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hepatoma</subject><subject>http://www.fao.org/aos/agrovoc#c_2086</subject><subject>http://www.fao.org/aos/agrovoc#c_4361</subject><subject>http://www.fao.org/aos/agrovoc#c_4787</subject><subject>http://www.fao.org/aos/agrovoc#c_5122</subject><subject>http://www.fao.org/aos/agrovoc#c_6464</subject><subject>hyperlipidemia</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>LIPID METABOLISM</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids - blood</subject><subject>Lipolysis - drug effects</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - physiopathology</subject><subject>Male</subject><subject>METABOLISME DES LIPIDES</subject><subject>METABOLISMO DE LIPIDOS</subject><subject>METHIONINE</subject><subject>Methionine - pharmacology</subject><subject>METIONINA</subject><subject>NEOPLASMAS</subject><subject>NEOPLASME</subject><subject>NEOPLASMS</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuLFDEUhYMoTs_owh-gFIiKixpz86ikltKMLwZ0oeuQVCXTGaqSNkkz9r83Nd2jIKKrJIfvnsvNuQg9AXwORMAbY8x5jztB76EVUCbarmfiPlrhHrpWMg4n6DTna4yrwOEhOiEYcwEEVujHOs5bnXyOoYmuKRvbWOfsUHJTlclv_djMtmgTJ5_nBRl9fab9om58DD7YRoexGfa5LHdjy421odnYrS5x1q2x1T5c3UIhpllPTdIlP0IPnJ6yfXw8z9C3dxdf1x_ay8_vP67fXraDIKy0uhsoGQCMlpJYKqkYeY-J4XWYjlngzOgOZOc40E4Y22FpqCXcaco55T09Q68OvtsUv-9sLmr2ebDTpIONu6wEo0AJl_L_JKWSYxC8ki__SRJYTBmp4PM_wOu4S6HOq4CxXjJC2GL3-kANKeacrFPb5Of6xwqwWgJWNWB1G3Blnx0dd2a24y_yLtEKvDgCOg96ckmHweffHKm70TFROXbgfHBLKjcxTaMqej_FdFdE_9b_6aHM6aj0VV0c9ekLwYCXPGr7n3NRxtc</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Kawasaki, M., Tokyo Univ. of Agriculture and Technology, Fuchu (Japan)</creator><creator>Miura, Y</creator><creator>Funabiki, R</creator><creator>Yagasaki, K</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>7TB</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>20100101</creationdate><title>Comparison of the effects on lipid metabolism of dietary methionine and cystine between hepatoma-bearing and normal rats</title><author>Kawasaki, M., Tokyo Univ. of Agriculture and Technology, Fuchu (Japan) ; Miura, Y ; Funabiki, R ; Yagasaki, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c724t-a6c32c11ba882e3837d5902b500064e154ba6186f51367be608b3e25fa3553593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - physiopathology</topic><topic>CISTINA</topic><topic>CYSTINE</topic><topic>Cystine - pharmacology</topic><topic>Diet</topic><topic>Eating - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hepatoma</topic><topic>http://www.fao.org/aos/agrovoc#c_2086</topic><topic>http://www.fao.org/aos/agrovoc#c_4361</topic><topic>http://www.fao.org/aos/agrovoc#c_4787</topic><topic>http://www.fao.org/aos/agrovoc#c_5122</topic><topic>http://www.fao.org/aos/agrovoc#c_6464</topic><topic>hyperlipidemia</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>LIPID METABOLISM</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipids - blood</topic><topic>Lipolysis - drug effects</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - physiopathology</topic><topic>Male</topic><topic>METABOLISME DES LIPIDES</topic><topic>METABOLISMO DE LIPIDOS</topic><topic>METHIONINE</topic><topic>Methionine - pharmacology</topic><topic>METIONINA</topic><topic>NEOPLASMAS</topic><topic>NEOPLASME</topic><topic>NEOPLASMS</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawasaki, M., Tokyo Univ. of Agriculture and Technology, Fuchu (Japan)</creatorcontrib><creatorcontrib>Miura, Y</creatorcontrib><creatorcontrib>Funabiki, R</creatorcontrib><creatorcontrib>Yagasaki, K</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawasaki, M., Tokyo Univ. of Agriculture and Technology, Fuchu (Japan)</au><au>Miura, Y</au><au>Funabiki, R</au><au>Yagasaki, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the effects on lipid metabolism of dietary methionine and cystine between hepatoma-bearing and normal rats</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>74</volume><issue>1</issue><spage>158</spage><epage>167</epage><pages>158-167</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The effects of dietary supplementation with methionine and cystine on lipid metabolism, including the serum lipid concentration, were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line (AH109A) for comparison with normal rats. A diet supplemented with 1.2% L-methionine or L-cystine to 20% casein was found to suppress the hepatoma-induced increases in serum triglyceride and total cholesterol concentration. The lipoprotein lipase activity in tissues was enhanced by dietary methionine and cystine, with no change in the mRNA level. Dietary methionine and cystine increased bile acid excretion into the feces with enhanced hepatic cholesterol 7α-hydroxylase activity. Dietary methionine and cystine affected the lipid metabolism differently in normal rats from hepatoma-bearing rats. 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| subjects | Animals Biological and medical sciences Body Weight - drug effects Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - physiopathology CISTINA CYSTINE Cystine - pharmacology Diet Eating - drug effects Fundamental and applied biological sciences. Psychology hepatoma http://www.fao.org/aos/agrovoc#c_2086 http://www.fao.org/aos/agrovoc#c_4361 http://www.fao.org/aos/agrovoc#c_4787 http://www.fao.org/aos/agrovoc#c_5122 http://www.fao.org/aos/agrovoc#c_6464 hyperlipidemia Hypolipidemic Agents - pharmacology LIPID METABOLISM Lipid Metabolism - drug effects Lipids - blood Lipolysis - drug effects Liver Neoplasms - blood Liver Neoplasms - metabolism Liver Neoplasms - physiopathology Male METABOLISME DES LIPIDES METABOLISMO DE LIPIDOS METHIONINE Methionine - pharmacology METIONINA NEOPLASMAS NEOPLASME NEOPLASMS RAT RATA RATS |
| title | Comparison of the effects on lipid metabolism of dietary methionine and cystine between hepatoma-bearing and normal rats |
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