Evaluation of Flagella and Flagellin of Pseudomonas aeruginosa as Vaccines

Pseudomonas aeruginosa is a serious pathogen in hospitalized, immunocompromised, and cystic fibrosis (CF) patients. P. aeruginosa is motile via a single polar flagellum made of polymerized flagellin proteins differentiated into two major serotypes: a and b. Antibodies to flagella delay onset of infe...

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Veröffentlicht in:	Infection and Immunity 2010-02, Vol.78 (2), p.746-755
Hauptverfasser:	Campodónico, Victoria L, Llosa, Nicolás J, Grout, Martha, Döring, Gerd, Maira-Litrán, Tomás, Pier, Gerald B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies Antibodies, Bacterial - immunology Antigens, Bacterial - immunology Applied microbiology Bacteriology Biological and medical sciences Clinical isolates Cystic fibrosis Enzyme-Linked Immunosorbent Assay Flagella Flagella - immunology Flagellin Flagellin - immunology Fundamental and applied biological sciences. Psychology Immunity Immunization Infection Mice Mice, Inbred C57BL Microbial Immunity and Vaccines Microbiology Miscellaneous Monomers Motility Pathogens Pneumonia Pseudomonas aeruginosa Pseudomonas aeruginosa - immunology Pseudomonas Infections - prevention & control Pseudomonas Vaccines - immunology Serotypes TLR5 protein Toll-Like Receptor 5 - immunology Toll-Like Receptor 5 - metabolism Toll-like receptors Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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