The effect of intracellular delivery of catalase and antisense oligonucleotides to NF-κB using albumin microcapsules in the endotoxic shock model

Microencapsulated (MC) catalase has been shown to inhibit H2O2 and tumor necrosis factor (TNF) in vitro after endotoxin stimulation. It is the purpose of this study to determine whether MC catalase improves pro-inflammatory cytokine inhibition and mortality in an endotoxic shock model in vivo. We al...

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Veröffentlicht in:	Journal of drug targeting 2009-11, Vol.17 (9), p.701-709
Hauptverfasser:	Siwale, Rodney C., Oettinger, Carl W., Addo, Richard, Siddig, Aladin, D'Souza, Martin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	antisense oligonucleotides to NF-κB Biological and medical sciences catalase endotoxic shock General pharmacology Hydrogen peroxide Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments reactive oxygen species TNF
Online-Zugang:	Volltext
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