Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA
Abstract Background Recent data have shown that plasma levels of lipopolysaccharide (LPS) are a quantitative indicator of microbial translocation in HIV infected individuals. Objectives To assess the impact of residual viral replication on plasma LPS in HAART-treated HIV+ subjects with
Gespeichert in:
| Veröffentlicht in: | Journal of clinical virology 2009, Vol.46 (4), p.367-370 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 370 |
|---|---|
| container_issue | 4 |
| container_start_page | 367 |
| container_title | Journal of clinical virology |
| container_volume | 46 |
| creator | Baroncelli, Silvia Galluzzo, Clementina Maria Pirillo, Maria Franca Mancini, Maria Grazia Weimer, Liliana Elena Andreotti, Mauro Amici, Roberta Vella, Stefano Giuliano, Marina Palmisano, Lucia |
| description | Abstract Background Recent data have shown that plasma levels of lipopolysaccharide (LPS) are a quantitative indicator of microbial translocation in HIV infected individuals. Objectives To assess the impact of residual viral replication on plasma LPS in HAART-treated HIV+ subjects with |
| doi_str_mv | 10.1016/j.jcv.2009.09.011 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_22153653</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1386653209004272</els_id><sourcerecordid>S1386653209004272</sourcerecordid><originalsourceid>FETCH-LOGICAL-e207t-cc40853746e36714400adab4f9c6dfafe537fdb6a96a94e497fbfdf18d83432c3</originalsourceid><addsrcrecordid>eNpdkUtLxDAUhYso-PwB7rJxJR3z6gtFGAZ1BB_gaxvS5AZvre2QdEZc-s9NHd0IhySQc0LOd5PkkNEJoyw_aSaNWU04pdVkFGMbyQ4rC5FmVV5sxrMo8zTPBN9OdkNoKGWZkMVO8nWLxvc16pYMXneh7Y0esO8IBqJD6A3qASz5wOGVeAhol9G5Qh9XD4sW_9wdmU-nD0_p4OEnML9-OSZhWTdghrCOn2WUmH6BEE7e29GQMvJwN91PtpxuAxz87nvJ8-XF02ye3txfXc-mNylwWgypMZKWmShkDiIvmJSUaqtr6SqTW6cdxDtn61xXURJkVbjaWcdKWwopuBF7ydH63YUORrcutjUY1MLju_afivNIJAKKvtO1D-JnVgheBYPQGbDoYxlle1SMqpG6alSkrkbqahRjMX3-L21a7CKm9g0-ITT90nexpWIqcEXV4ziXcSy0olTygotvRmqMPA</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Baroncelli, Silvia ; Galluzzo, Clementina Maria ; Pirillo, Maria Franca ; Mancini, Maria Grazia ; Weimer, Liliana Elena ; Andreotti, Mauro ; Amici, Roberta ; Vella, Stefano ; Giuliano, Marina ; Palmisano, Lucia</creator><creatorcontrib>Baroncelli, Silvia ; Galluzzo, Clementina Maria ; Pirillo, Maria Franca ; Mancini, Maria Grazia ; Weimer, Liliana Elena ; Andreotti, Mauro ; Amici, Roberta ; Vella, Stefano ; Giuliano, Marina ; Palmisano, Lucia</creatorcontrib><description>Abstract Background Recent data have shown that plasma levels of lipopolysaccharide (LPS) are a quantitative indicator of microbial translocation in HIV infected individuals. Objectives To assess the impact of residual viral replication on plasma LPS in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA and to evaluate LPS changes during repeated HAART interruptions not exceeding 2-month duration. Study design LPS was measured in 44 HIV+ subjects at T0 (during HAART) and at day 15 of the first and fourth HAART interruption. Ten uninfected, healthy donors were studied as well. Residual plasma HIV-1 RNA was measured at T0 by an ultra-ultrasensitive method with limit of detection of 2.5 copies HIV-1 RNA/ml. Subjects with less than 2.5 copies/ml (fully suppressed – FS) were compared to those with 2.5–50 copies/ml (partially suppressed – PS). Results At T0, plasma LPS levels were comparable in FS and uninfected subjects, whereas in PS they were higher than in uninfected subjects ( p = 0.049). After 4 HAART interruptions, they did not change significantly. However, LPS values were lower in FS than in PS ( p = 0.020). An inverse correlation was found between CD4 and LPS levels ( p = 0.044) in PS group only. Conclusions A reduced degree of microbial translocation was seen in subjects with a more complete suppression of viral replication. Repeated HAART interruptions had no significant impact on plasma LPS levels.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2009.09.011</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Allergy and Immunology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; HAART ; HIV infection ; Human viral diseases ; Infectious Disease ; Infectious diseases ; Lipopolysaccharide ; Medical sciences ; Microbial translocation ; Microbiology ; Miscellaneous ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral suppression ; Virology</subject><ispartof>Journal of clinical virology, 2009, Vol.46 (4), p.367-370</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcv.2009.09.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22153653$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Baroncelli, Silvia</creatorcontrib><creatorcontrib>Galluzzo, Clementina Maria</creatorcontrib><creatorcontrib>Pirillo, Maria Franca</creatorcontrib><creatorcontrib>Mancini, Maria Grazia</creatorcontrib><creatorcontrib>Weimer, Liliana Elena</creatorcontrib><creatorcontrib>Andreotti, Mauro</creatorcontrib><creatorcontrib>Amici, Roberta</creatorcontrib><creatorcontrib>Vella, Stefano</creatorcontrib><creatorcontrib>Giuliano, Marina</creatorcontrib><creatorcontrib>Palmisano, Lucia</creatorcontrib><title>Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA</title><title>Journal of clinical virology</title><description>Abstract Background Recent data have shown that plasma levels of lipopolysaccharide (LPS) are a quantitative indicator of microbial translocation in HIV infected individuals. Objectives To assess the impact of residual viral replication on plasma LPS in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA and to evaluate LPS changes during repeated HAART interruptions not exceeding 2-month duration. Study design LPS was measured in 44 HIV+ subjects at T0 (during HAART) and at day 15 of the first and fourth HAART interruption. Ten uninfected, healthy donors were studied as well. Residual plasma HIV-1 RNA was measured at T0 by an ultra-ultrasensitive method with limit of detection of 2.5 copies HIV-1 RNA/ml. Subjects with less than 2.5 copies/ml (fully suppressed – FS) were compared to those with 2.5–50 copies/ml (partially suppressed – PS). Results At T0, plasma LPS levels were comparable in FS and uninfected subjects, whereas in PS they were higher than in uninfected subjects ( p = 0.049). After 4 HAART interruptions, they did not change significantly. However, LPS values were lower in FS than in PS ( p = 0.020). An inverse correlation was found between CD4 and LPS levels ( p = 0.044) in PS group only. Conclusions A reduced degree of microbial translocation was seen in subjects with a more complete suppression of viral replication. Repeated HAART interruptions had no significant impact on plasma LPS levels.</description><subject>Allergy and Immunology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HAART</subject><subject>HIV infection</subject><subject>Human viral diseases</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Lipopolysaccharide</subject><subject>Medical sciences</subject><subject>Microbial translocation</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral suppression</subject><subject>Virology</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNpdkUtLxDAUhYso-PwB7rJxJR3z6gtFGAZ1BB_gaxvS5AZvre2QdEZc-s9NHd0IhySQc0LOd5PkkNEJoyw_aSaNWU04pdVkFGMbyQ4rC5FmVV5sxrMo8zTPBN9OdkNoKGWZkMVO8nWLxvc16pYMXneh7Y0esO8IBqJD6A3qASz5wOGVeAhol9G5Qh9XD4sW_9wdmU-nD0_p4OEnML9-OSZhWTdghrCOn2WUmH6BEE7e29GQMvJwN91PtpxuAxz87nvJ8-XF02ye3txfXc-mNylwWgypMZKWmShkDiIvmJSUaqtr6SqTW6cdxDtn61xXURJkVbjaWcdKWwopuBF7ydH63YUORrcutjUY1MLju_afivNIJAKKvtO1D-JnVgheBYPQGbDoYxlle1SMqpG6alSkrkbqahRjMX3-L21a7CKm9g0-ITT90nexpWIqcEXV4ziXcSy0olTygotvRmqMPA</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Baroncelli, Silvia</creator><creator>Galluzzo, Clementina Maria</creator><creator>Pirillo, Maria Franca</creator><creator>Mancini, Maria Grazia</creator><creator>Weimer, Liliana Elena</creator><creator>Andreotti, Mauro</creator><creator>Amici, Roberta</creator><creator>Vella, Stefano</creator><creator>Giuliano, Marina</creator><creator>Palmisano, Lucia</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope></search><sort><creationdate>2009</creationdate><title>Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA</title><author>Baroncelli, Silvia ; Galluzzo, Clementina Maria ; Pirillo, Maria Franca ; Mancini, Maria Grazia ; Weimer, Liliana Elena ; Andreotti, Mauro ; Amici, Roberta ; Vella, Stefano ; Giuliano, Marina ; Palmisano, Lucia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e207t-cc40853746e36714400adab4f9c6dfafe537fdb6a96a94e497fbfdf18d83432c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Allergy and Immunology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HAART</topic><topic>HIV infection</topic><topic>Human viral diseases</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Lipopolysaccharide</topic><topic>Medical sciences</topic><topic>Microbial translocation</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral suppression</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baroncelli, Silvia</creatorcontrib><creatorcontrib>Galluzzo, Clementina Maria</creatorcontrib><creatorcontrib>Pirillo, Maria Franca</creatorcontrib><creatorcontrib>Mancini, Maria Grazia</creatorcontrib><creatorcontrib>Weimer, Liliana Elena</creatorcontrib><creatorcontrib>Andreotti, Mauro</creatorcontrib><creatorcontrib>Amici, Roberta</creatorcontrib><creatorcontrib>Vella, Stefano</creatorcontrib><creatorcontrib>Giuliano, Marina</creatorcontrib><creatorcontrib>Palmisano, Lucia</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baroncelli, Silvia</au><au>Galluzzo, Clementina Maria</au><au>Pirillo, Maria Franca</au><au>Mancini, Maria Grazia</au><au>Weimer, Liliana Elena</au><au>Andreotti, Mauro</au><au>Amici, Roberta</au><au>Vella, Stefano</au><au>Giuliano, Marina</au><au>Palmisano, Lucia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA</atitle><jtitle>Journal of clinical virology</jtitle><date>2009</date><risdate>2009</risdate><volume>46</volume><issue>4</issue><spage>367</spage><epage>370</epage><pages>367-370</pages><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>Abstract Background Recent data have shown that plasma levels of lipopolysaccharide (LPS) are a quantitative indicator of microbial translocation in HIV infected individuals. Objectives To assess the impact of residual viral replication on plasma LPS in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA and to evaluate LPS changes during repeated HAART interruptions not exceeding 2-month duration. Study design LPS was measured in 44 HIV+ subjects at T0 (during HAART) and at day 15 of the first and fourth HAART interruption. Ten uninfected, healthy donors were studied as well. Residual plasma HIV-1 RNA was measured at T0 by an ultra-ultrasensitive method with limit of detection of 2.5 copies HIV-1 RNA/ml. Subjects with less than 2.5 copies/ml (fully suppressed – FS) were compared to those with 2.5–50 copies/ml (partially suppressed – PS). Results At T0, plasma LPS levels were comparable in FS and uninfected subjects, whereas in PS they were higher than in uninfected subjects ( p = 0.049). After 4 HAART interruptions, they did not change significantly. However, LPS values were lower in FS than in PS ( p = 0.020). An inverse correlation was found between CD4 and LPS levels ( p = 0.044) in PS group only. Conclusions A reduced degree of microbial translocation was seen in subjects with a more complete suppression of viral replication. Repeated HAART interruptions had no significant impact on plasma LPS levels.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.jcv.2009.09.011</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1386-6532 |
| ispartof | Journal of clinical virology, 2009, Vol.46 (4), p.367-370 |
| issn | 1386-6532 1873-5967 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_22153653 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Allergy and Immunology Biological and medical sciences Fundamental and applied biological sciences. Psychology HAART HIV infection Human viral diseases Infectious Disease Infectious diseases Lipopolysaccharide Medical sciences Microbial translocation Microbiology Miscellaneous Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral suppression Virology |
| title | Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T10%3A32%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microbial%20translocation%20is%20associated%20with%20residual%20viral%20replication%20in%20HAART-treated%20HIV+%20subjects%20with%20%3C50%20copies/ml%20HIV-1%20RNA&rft.jtitle=Journal%20of%20clinical%20virology&rft.au=Baroncelli,%20Silvia&rft.date=2009&rft.volume=46&rft.issue=4&rft.spage=367&rft.epage=370&rft.pages=367-370&rft.issn=1386-6532&rft.eissn=1873-5967&rft_id=info:doi/10.1016/j.jcv.2009.09.011&rft_dat=%3Celsevier_pasca%3ES1386653209004272%3C/elsevier_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_els_id=S1386653209004272&rfr_iscdi=true |