MT1-MMP-Mediated Cleavage of Decorin in Corneal Angiogenesis

Background/Aims: Decorin has been shown to have antiangiogenic properties. In this study, we evaluate the involvement of membrane type 1-matrix metalloproteinase (MT1-MMP), a proangiogenic enzyme, in decorin cleavage in the cornea. Methods: MT1-MMP expression was confirmed immunohistochemically in k...

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Veröffentlicht in:	Journal of vascular research 2009-01, Vol.46 (6), p.541-550
Hauptverfasser:	Mimura, Tatsuya, Han, Kyu Yeon, Onguchi, Tatsuya, Chang, Jin-Hong, Kim, Tae-im, Kojima, Takashi, Zhou, Zhongjun, Azar, Dimitri T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - enzymology Biological and medical sciences Cell Line Cornea - enzymology Corneal Neovascularization - chemically induced Corneal Neovascularization - enzymology Culture Media, Conditioned - metabolism Decorin Dipeptides - pharmacology Disease Models, Animal Extracellular Matrix Proteins - metabolism Fibroblast Growth Factor 2 Fundamental and applied biological sciences. Psychology Kinetics Matrix Metalloproteinase 14 - deficiency Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 14 - metabolism Matrix Metalloproteinase Inhibitors Mice Mice, Inbred C57BL Mice, Knockout Protease Inhibitors - pharmacology Proteoglycans - metabolism Recombinant Proteins - metabolism Research Paper Tissue Culture Techniques Transfection Vertebrates: cardiovascular system
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